Abstract: A method for predicting the sensitivity of tumor cells to an anthracycline-based chemotherapy includes determining the differential expression level of a MYBL2 gene in tumors cells. A polynucleotide library is useful to predict the sensitivity of tumor cells to an anthracycline-based chemotherapy and includes a pool of polynucleotide sequences or subsequences thereof wherein the sequences or subsequences correspond substantially to any of the polynucleotide sequences SEQ ID No: 308, SEQ ID No: 309 and/or SEQ ID No: 310 or the complements thereof.

Abstract: Method for molecular characterization of a carcinoma including: (i) detecting in tumor cells corresponding to breast tumor cells at least one polynucleotide selected from a first group determining expression level of the polynucleotide from the first group to differentiate a tumor in which a lymph node has been invaded by a tumor cell from a tumor in which a lymph node has not been invaded by a tumor cell; (ii) detecting in tumor cells corresponding to breast tumor cells at least one polynucleotide selected from a second group determining expression level of the polynucleotide from the second group to distinguish tumors sensitive to anthracycline from tumors insensitive to anthracycline; (iii) detecting in tumor cells corresponding to breast tumor cells at least one polynucleotide selected from a third group determining expression levels of the polynucleotide from the third group to classify good and poor prognosis primary breast tumors.

Abstract: The present invention relates to a method of assessing a propensity of clinical outcome for a female mammal suffering from breast cancer in view of the expression of specific nucleic acid sequences in a biological sample.

Abstract: A process for analyzing a complex biological state of a biosystem from a sample of nucleic acids isolated from the biosystem including hybridization of the nucleic acids with probes fixed on a support, including: (a) contacting marked polynucleotide sequences prepared from nucleic acids of the sample with a first set of specific polynucleotide probes (E1) of a biological state and at least a second set of reference polynucleotide probes (E2) prepared from a molecule of reference nucleic acid for the biological state under conditions permitting the formation of hybridization products, and (b) detecting the hybridization products formed in step (a), wherein the first and second sets (E1, E2) are fixed on a support and the first set of probes includes n groups of probes, each group being characteristic of a different genetic profile that influences the biological state and can therefore alter it, and each group being assembled on the support in separate positions that are also separated from that (those) of the

Abstract: A polynucleotide library useful in the molecular characterization of a carcinoma, the library including a pool of polynucleotide sequences or subsequences thereof wherein the sequences or subsequences are overexpressed in tumor cells, further wherein the sequences or subsequences correspond substantially to any of the polynucleotide sequences set forth in any of SEQ ID NOS: 1-468 or the complement thereof.

Abstract: The invention concerns a method for quantitative measuring of gene expression by obtaining marked probes of pre-selected homogeneous size, after reverse transcription and amplification. The invention also concerns the method for preparing marked probes, and implementing kits using microarrays and macroarrays.

Abstract: The invention relates to a process for producing FVIII/vWF complexes for therapeutical use possessing both haemophilic A activity and Willebrand activity as well as a high degree of purity, such process substantially comprising the steps of fixing the FVIII/vWF complex in physiological conditions on a particular monoclonal antibody and releasing said complex by means of a suitable elution medium having no effct on the functions of the FVIII/vWF complex but able to dissociate the bonds linking the selected monoclonal anitbody to the FVIII/vWF complex, then collecting the latter in a highly purified form.