Patents by Inventor Vincent FLORIO

Vincent FLORIO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dichlorophenol HSD17B13 inhibitors and uses thereof
    Patent number: 12227489
    Abstract: Described herein are HSD17B13 inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of liver disease, metabolic disease, or cardiovascular disease, such as NAFLD or NASH, or drug induced liver injury (DILI).
    Type: Grant
    Filed: October 2, 2023
    Date of Patent: February 18, 2025
    Assignee: INIPHARM, INC.
    Inventors: Sampath Kumar Anandan, Joshua Odingo, Heather Kay Webb Hsu, Vincent Florio, Subramanyam Janardhan Tantry, Athisayamani Jeyaraj Duraiswamy
  • HYDROXYPYRIDINE HSD17B13 INHIBITORS AND USES THEREOF
    Publication number: 20240208929
    Abstract: Described herein are hydroxypyridine HSD17B13 inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of liver disease, metabolic disease, or cardiovascular disease, such as NAFLD or NASH, or drug induced liver injury (DILI).
    Type: Application
    Filed: April 4, 2022
    Publication date: June 27, 2024
    Inventors: Joshua ODINGO, Sampath Kumar ANANDAN, Heather Kay Webb HSU, Vincent FLORIO, Subramanyam Janardhan TANTRY, Athisayamani Jeyaraj DURAISWAMY, Bharathi Mohan KUPPUSAMY
  • THIAZOLE/ISOTHIAZOLE HSD17B13 INHIBITORS AND USES THEREOF
    Publication number: 20240208959
    Abstract: Described herein are HSD17B13 inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of liver disease, metabolic disease, or cardiovascular disease, such as NAFLD or NASHI, or drug induced liver injury (DILI).
    Type: Application
    Filed: April 4, 2022
    Publication date: June 27, 2024
    Inventors: Joshua ODINGO, Sampath Kumar ANANDAN, Heather Kay Webb HSU, Vincent FLORIO, Subramanyam Janardhan TANTRY, Athisayamani Jeyaraj DURAISWAMY, Bharathi Mohan KUPPUSAMY
  • DICHLOROPHENOL HSD17B13 INHIBITORS AND USES THEREOF
    Publication number: 20240150314
    Abstract: Described herein are HSD17B13 inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of liver disease, metabolic disease, or cardiovascular disease, such as NAFLD or NASH, or drug induced liver injury (DILI).
    Type: Application
    Filed: October 2, 2023
    Publication date: May 9, 2024
    Inventors: Sampath Kumar ANANDAN, Joshua ODINGO, Heather Kay Webb HSU, Vincent FLORIO, Subramanyam Janardhan TANTRY, Athisayamani Jeyaraj DURAISWAMY
  • SPECIFIC SUBSTRATES AND PRODUCTS OF HSD17B13 AS MARKERS OF LIVER DISEASE AND BIOMARKERS FOR LIVER DISEASE TREATMENT
    Publication number: 20230416802
    Abstract: Provided are HSD17B13 substrates, reaction products, kits, and methods that include the HSD17B13 substrates or reaction products of the HSD17B13 substrates. Some embodiments include methods of treatment. Some such embodiments include determining an amount of an HSD17B13 substrate or of a reaction product of the HSD17B13 substrate in a sample from the subject to whom the HSD17B13 substrate has been administered.
    Type: Application
    Filed: November 3, 2021
    Publication date: December 28, 2023
    Inventors: Heather Kay Webb HSU, Vincent FLORIO, Michael CARLETON, Joshua ODINGO
  • Dichlorophenol HSD17B13 inhibitors and uses thereof
    Patent number: 11827619
    Abstract: Described herein are HSD17B13 inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of liver disease, metabolic disease, or cardiovascular disease, such as NAFLD or NASH, or drug induced liver injury (DILI).
    Type: Grant
    Filed: May 10, 2023
    Date of Patent: November 28, 2023
    Assignee: INIPHARM, INC.
    Inventors: Sampath Kumar Anandan, Joshua Odingo, Heather Kay Webb Hsu, Vincent Florio, Subramanyam Janardhan Tantry, Athisayamani Jeyaraj Duraiswamy
  • QUINAZOLINONE HSD17B13 INHIBITORS AND USES THEREOF
    Publication number: 20230286923
    Abstract: Described herein are HSD17B13 inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of liver disease, metabolic disease, or cardiovascular disease, such as NAFLD or NASH, or drug induced liver injury (DILI).
    Type: Application
    Filed: July 23, 2021
    Publication date: September 14, 2023
    Inventors: Joshua ODINGO, Sampath Kumar ANANDAN, Heather Kay Webb HSU, Vincent FLORIO, Subramanyam Janardhan TANTRY, Athisayamani Jeyaraj DURAISWAMY, Bharathi Mohan KUPPUSAMY
  • THIOPHENE HSD17B13 INHIBITORS AND USES THEREOF
    Publication number: 20230278978
    Abstract: Described herein are HSD17B13 inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of liver disease, metabolic disease, or cardiovascular disease, such as NAFLD or NASH, or drug induced liver injury (DILI).
    Type: Application
    Filed: July 23, 2021
    Publication date: September 7, 2023
    Inventors: Joshua ODINGO, Sampath Kumar ANANDAN, Heather Kay Webb HSU, Vincent FLORIO, Subramanyam Janardhan TANTRY, Athisayamani Jeyaraj DURAISWAMY
  • DICHLOROPHENOL HSD17B13 INHIBITORS AND USES THEREOF
    Publication number: 20230278981
    Abstract: Described herein are HSD17B13 inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of liver disease, metabolic disease, or cardiovascular disease, such as NAFLD or NASH, or drug induced liver injury (DILI).
    Type: Application
    Filed: May 10, 2023
    Publication date: September 7, 2023
    Inventors: Sampath Kumar ANANDAN, Joshua ODINGO, Heather Kay Webb HSU, Vincent FLORIO, Subramanyam Janardhan TANTRY, Athisayamani Jeyaraj DURAISWAMY
  • ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE 1 (ENPP-1) INHIBITORS AND USES THEREOF
    Publication number: 20230183239
    Abstract: Disclosed herein are methods and compounds of augmenting and enhancing the production of type I IFNs in vivo. In some embodiments, the compounds disclosed herein are ENPP-1 inhibitors, pharmaceutical compositions, and methods for the treatment of cancer or a viral infection.
    Type: Application
    Filed: March 23, 2022
    Publication date: June 15, 2023
    Inventors: William Michael GALLATIN, Joshua ODINGO, Gregory N. DIETSCH, Vincent FLORIO, Chandregowda VENKATESHAPPA, Athisayamani Jeyaraj DURAISWAMY
  • HSD17B13 INHIBITORS AND USES THEREOF
    Publication number: 20230150940
    Abstract: Described herein are HSD17B13 inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of liver disease, metabolic disease, or cardiovascular disease, such as NAFLD or NASH, or drug induced liver injury (DILI).
    Type: Application
    Filed: April 16, 2021
    Publication date: May 18, 2023
    Inventors: Joshua ODINGO, Heather Kay Webb HSU, Vincent FLORIO, Subramanyam Janardhan TANTRY, Rajendra KRISTAM, Athisayamani Jeyara DURAISWAMY
  • ECTONUCLEOTIDE PYROPHOSPHATE-PHOSPHODIESTERASE (ENPP) CONJUGATES AND USES THEREOF
    Publication number: 20210023234
    Abstract: Disclosed herein are ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) complexes and synthetic molecules that interact with an ENPP protein. In some embodiments, also disclosed herein are modified ENPP polypeptides in complex with a synthetic molecule described herein.
    Type: Application
    Filed: March 28, 2019
    Publication date: January 28, 2021
    Inventors: William Michael GALLATIN, Gregory N DIETSCH, Joshua ODINGO, Vincent FLORIO
  • ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE 1 (ENPP-1) INHIBITORS AND USES THEREOF
    Publication number: 20200291024
    Abstract: Disclosed herein are methods and compounds of augmenting and enhancing the production of type I IFNs in vivo. In some embodiments, the compounds disclosed herein are ENPP-1 inhibitors, pharmaceutical compositions, and methods for the treatment of cancer or a viral infection.
    Type: Application
    Filed: August 31, 2018
    Publication date: September 17, 2020
    Inventors: William Michael GALLATIN, Joshua ODINGO, Gregory N. DIETSCH, Vincent FLORIO
  • ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE (ENPP) CONJUGATES AND USES THEREOF
    Publication number: 20190282703
    Abstract: Disclosed herein are ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) complexes and synthetic molecules that interact with an ENPP protein. In some embodiments, also disclosed herein are modified ENPP polypeptides in complex with a synthetic molecule described herein.
    Type: Application
    Filed: March 13, 2018
    Publication date: September 19, 2019
    Inventors: William Michael GALLATIN, Gregory N. DIETSCH, Joshua ODINGO, Vincent FLORIO