Patents by Inventor Vincent Frans Maria Segers

Vincent Frans Maria Segers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • QUINAZOLIN-4-ONE AND THIENO[2,3-D]PYRIMIDIN-4-ONE INHIBITORS OF ERBB4 (HER4) FOR USE IN THE TREATMENT OF CANCER
    Publication number: 20240002351
    Abstract: The present invention relates to a compound of formula (I) or a stereoisomer, or tautomer, for use in the prevention or treatment of a disease associated with the activation of receptor tyrosine-protein kinase (erbB4). In formula (I), wherein n, A1, A2, A3, A4, A5, R1, R2, R3, and R4 have the same meaning as that defined in the claims and the description. The present invention also relates uses of such compounds for the prevention and/or treatment of a disease associated with the activation of receptor tyrosine-protein kinase (erbB-4) such as heart failure, metabolic disorders, inflammatory disorders, fibrotic disorders, and cancer. The present invention also provides pharmaceutical compositions comprising such compounds, as well as the use of the compounds as a medicament.
    Type: Application
    Filed: March 4, 2022
    Publication date: January 4, 2024
    Applicant: UNIVERSITEIT ANTWERPEN
    Inventors: Vincent Frans Maria SEGERS, Gilles Willy DE KEULENAER, Eline FEYEN, Hans Louis Jos DE WINTER
  • Protease-resistant mutants of stromal cell derived factor-1 in the repair of tissue damage
    Patent number: 10456451
    Abstract: The present invention features mutant stromal cell derived factor-1 (SDF-1) peptides that have been mutated to make them resistant to digestion by, for example, the proteases dipeptidyl peptidase IV (DPPIV), matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), leukocyte elastase, cathepsin G, carboxypeptidase M, and carboxypeptidase N, but which retain chemoattractant activity.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: October 29, 2019
    Assignee: Mesoblast International Sàrl
    Inventors: Vincent Frans Maria Segers, Anthony Sandrasagra, Yan Qiu
  • PROTEASE-RESISTANT MUTANTS OF STROMAL CELL DERIVED FACTOR-1 IN THE REPAIR OF TISSUE DAMAGE
    Publication number: 20160375100
    Abstract: The present invention features mutant stromal cell derived factor-1 (SDF-1) peptides that have been mutated to make them resistant to digestion by, for example, the proteases dipeptidyl peptidase IV (DPPIV), matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), leukocyte elastase, cathepsin G, carboxypeptidase M, and carboxypeptidase N, but which retain chemoattractant activity.
    Type: Application
    Filed: February 26, 2016
    Publication date: December 29, 2016
    Inventors: Vincent Frans Maria SEGERS, Anthony SANDRASAGRA, Yan QIU
  • Protease-resistant mutants of stromal cell derived factor-1 in the repair of tissue damage
    Patent number: 9308277
    Abstract: The present invention features mutant stromal cell derived factor-1 (SDF-1) peptides that have been mutated to make them resistant to digestion by, for example, the proteases dipeptidyl peptidase IV (DPPIV), matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), leukocyte elastase, cathepsin G, carboxypeptidase M, and carboxypeptidase N, but which retain chemoattractant activity.
    Type: Grant
    Filed: February 17, 2011
    Date of Patent: April 12, 2016
    Assignee: Mesoblast International Sàrl
    Inventors: Vincent Frans Maria Segers, Anthony Sandrasagra, Yan Qiu
  • PROTEASE-RESISTANT MUTANTS OF STROMAL CELL DERIVED FACTOR-1 IN THE REPAIR OF TISSUE DAMAGE
    Publication number: 20110224139
    Abstract: The present invention features mutant stromal cell derived factor-1 (SDF-1) peptides that have been mutated to make them resistant to digestion by, for example, the proteases dipeptidyl peptidase IV (DPPIV), matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), leukocyte elastase, cathepsin G, carboxypeptidase M, and carboxypeptidase N, but which retain chemoattractant activity.
    Type: Application
    Filed: February 17, 2011
    Publication date: September 15, 2011
    Applicant: Provasculon, Inc.
    Inventors: Vincent Frans Maria Segers, Anthony Sandrasagra, Yan Qiu