Patents by Inventor Vincent GEMBUS

Vincent GEMBUS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1,2,4-triazine derivatives for the treatment of viral infections
    Patent number: 9416114
    Abstract: This invention relates to 1,2,4-triazine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
    Type: Grant
    Filed: October 1, 2013
    Date of Patent: August 16, 2016
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE ROUEN, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE ROUEN (INSA)
    Inventors: Vincent Gembus, Philippe Jubault, Christophe Hoarau, Vincent Levacher, Jean-Francois Bonfanti, David Graig McGowan, Jerome Emile Georges Guillemont
  • Oxidisable pyridine derivatives, their preparation and use as anti-alzheimer agents
    Patent number: 9376387
    Abstract: A compound of formula (I) in which the dotted lines indicate the presence of at least one double bond; n=0 to 4; R3 and R4 are H, or when n=1, R3 and R4 can also form together a double bond between the carbon atoms, and m=0, 1 or 2, Z is CH or N or Z is C and —CHR3— is ?CH— linked by the double bond to cyclopentanone; or ?(?)m- is absent, and Z is NH, >N-alkyl, >N-phenyl, >N-benzyl or >N heteroaryl; R8 is alkyl, aryl or heteroaryl which can be optionally substituted; EWG represents an electron withdrawing group selected from the group comprising COOR, COSR, CONRR?, CN, COR, CF3, SOR, SO2R, SONRR?, SO2NRR?, NO2, halogen, heteroaryl; and the pharmaceutical salts and stereisomers thereof. The compounds of formula (I) are potent in the treatment of neurodegenerative diseases such as Alzheimer's disease.
    Type: Grant
    Filed: January 24, 2014
    Date of Patent: June 28, 2016
    Inventors: Francis Marsais, Vincent Levacher, Cyril Papamicael, Pierre Bohn, Ludovic Peauger, Vincent Gembus, Nicolas Le Fur, Marie-Laurence Dumartin-Lepine
  • OXIDISABLE PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE AS ANTI-ALZHEIMER AGENTS
    Publication number: 20150353493
    Abstract: A compound of formula (I) in which the dotted lines indicate the presence of at least one double bond; n=0 to 4; R3 and R4 are H, or when n=1, R3 and R4 can also form together a double bond between the carbon atoms, and m=0, 1 or 2, Z is CH or N or Z is C and —CHR3— is ?CH— linked by the double bond to cyclopentanone; or ?(?)m- is absent, and Z is NH, >N-alkyl, >N-phenyl, >N-benzyl or >N heteroaryl; R8 is alkyl, aryl or heteroaryl which can be optionally substituted; EWG represents an electron withdrawing group selected from the group comprising COOR, COSR, CONRR?, CN, COR, CF3, SOR, SO2R, SONRR?, SO2NRR?, NO2, halogen, heteroaryl; and the pharmaceutical salts and stereisomers thereof. The compounds of formula (I) are potent in the treatment of neurodegenerative diseases such as Alzheimer's disease.
    Type: Application
    Filed: January 24, 2014
    Publication date: December 10, 2015
    Applicants: INSA (INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE ROUEN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE ROUEN, VFP THERAPIES
    Inventors: Francis MARSAIS, Vincent LEVACHER, Cyril PAPAMICAEL, Pierre BOHN, Ludovic PEAUGER, Vincent GEMBUS, Nicolas LE FUR, Marie-Laurence DUMARTIN-LEPINE
  • 1,2,4-TRIAZINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS
    Publication number: 20150336907
    Abstract: This invention relates to 1,2,4-triazine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
    Type: Application
    Filed: October 1, 2013
    Publication date: November 26, 2015
    Inventors: Vincent GEMBUS, Philippe JUBAULT, Christophe HOARAU, Vincent LEVACHER, Jean-Francois BONFANTI, David Graig MC GOWAN, Jerome Emile Georges GUILLEMONT