Patents by Inventor Vincent Giranda

Vincent Giranda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • VELIPARIB IN COMBINATION WITH CARBOPLATIN AND PACLITAXEL FOR THE TREATMENT OF NON-SMALL CELL LUNG CANCER IN SMOKERS
    Publication number: 20170172985
    Abstract: This invention pertains to a method for the treatment of non-small cell lung cancer in a subject who is a smoker, comprising administering to the subject an effective amount of 2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (veliparib or ABT-888), or a pharmaceutically acceptable salt thereof, in combination with carboplatin and paclitaxel.
    Type: Application
    Filed: March 6, 2017
    Publication date: June 22, 2017
    Inventors: Vincent Giranda, Gary Gordon, Mark D. McKee, Jane Qian, Qin Qin
  • Veliparib in combination with carboplatin and paclitaxel for the treatment of non-small cell lung cancer in smokers
    Patent number: 9623009
    Abstract: This invention pertains to a method for the treatment of non-small cell lung cancer in a subject who is a smoker, comprising administering to the subject an effective amount of 2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (veliparib or ABT-888), or a pharmaceutically acceptable salt thereof, in combination with carboplatin and paclitaxel.
    Type: Grant
    Filed: September 16, 2015
    Date of Patent: April 18, 2017
    Assignee: AbbVie, Inc.
    Inventors: Vincent Giranda, Gary Gordon, Mark D. McKee, Jane Qian, Qin Qin
  • VELIPARIB IN COMBINATION WITH CARBOPLATIN AND PACLITAXEL FOR THE TREATMENT OF NON-SMALL CELL LUNG CANCER IN SMOKERS
    Publication number: 20160074368
    Abstract: This invention pertains to a method for the treatment of non-small cell lung cancer in a subject who is a smoker, comprising administering to the subject an effective amount of 2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (veliparib or ABT-888), or a pharmaceutically acceptable salt thereof, in combination with carboplatin and paclitaxel.
    Type: Application
    Filed: September 16, 2015
    Publication date: March 17, 2016
    Applicant: AbbVie Inc.
    Inventors: Vincent Giranda, Gary Gordon, Mark D. McKee, Jane Qian, Qin Qin
  • POLY(ADP-RIBOSE)POLYMERASE INHIBITORS
    Publication number: 20080108659
    Abstract: Compounds which inhibit the activity of poly(ADP-ribose)polymerase, compositions containing the compounds and methods of treating diseases using the compounds is disclosed.
    Type: Application
    Filed: October 4, 2007
    Publication date: May 8, 2008
    Inventors: Virajkumar Gandhi, Vincent Giranda, Thomas Penning, Gui-Dong Zhu
  • INHIBITORS OF POLO-LIKE KINASES
    Publication number: 20080015192
    Abstract: Compounds that inhibit Plk1, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
    Type: Application
    Filed: May 24, 2007
    Publication date: January 17, 2008
    Inventors: Robert Diebold, Stevan Djuric, Vincent Giranda, Laura Hexamer, Nan-Horng Lin, Julie Miyashiro, Thomas Penning, Magdalena Przytulinska, Thomas Sowin, Gerard Sullivan, Zhi-Fu Tao, Yunsong Tong, Anil Vasudevan, Le Wang, Keith Woods, Zhiren Xia, Henry Zhang
  • Potent PARP Inhibitors
    Publication number: 20080015182
    Abstract: The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.
    Type: Application
    Filed: June 20, 2007
    Publication date: January 17, 2008
    Inventors: Thomas Penning, Sheela Thomas, Philip Hajduk, Daryl Sauer, Kathy Sarris, Vincent Giranda
  • SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS
    Publication number: 20070270476
    Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
    Type: Application
    Filed: July 30, 2007
    Publication date: November 22, 2007
    Inventors: Thomas Penning, Sheela Thomas, Gui-Dong Zhu, Jianchun Gong, Vincent Giranda, Viraj Gandhi
  • Combination Therapy with Parp Inhibitors
    Publication number: 20070265324
    Abstract: The present invention describes benzimidazole derivatives of Formula (I) which constitute potent PARP inhibitors in combination with radiotherapy or in combination with other chemotherapeutic agents.
    Type: Application
    Filed: January 17, 2007
    Publication date: November 15, 2007
    Inventors: Wolfgang Wernet, Thomas Penning, Vincent Giranda
  • PYRAZOLOQUINOLONES ARE POTENT PARP INHIBITORS
    Publication number: 20070249597
    Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
    Type: Application
    Filed: February 15, 2007
    Publication date: October 25, 2007
    Inventors: THOMAS PENNING, Gui-Dong Zhu, Virajkumar Gandhi, Jianchun Gong, Vincent Giranda
  • 1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH PHENYL AT THE 2-POSITION ARE POTENT PARP INHIBITORS
    Publication number: 20070179136
    Abstract: Compound having formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds having formula (I), methods of treatment comprising compounds having formula (I), and methods of inhibiting the PARP enzyme comprising compounds having formula (I).
    Type: Application
    Filed: September 29, 2006
    Publication date: August 2, 2007
    Inventors: Thomas Penning, Sheela Thomas, Gui-Dong Zhu, Virajkumar Gandhi, Jianchun Gong, Vincent Giranda
  • SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS
    Publication number: 20070112047
    Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
    Type: Application
    Filed: November 15, 2006
    Publication date: May 17, 2007
    Inventors: Thomas Penning, Sheela Thomas, Gui-Dong Zhu, Jianchun Gong, Vincent Giranda, Viraj Gandhi
  • 2-Substituted-1 H-benzimidazile-4-carboxamides are PARP inhibitors
    Publication number: 20060229351
    Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), method of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compound of Formula (I).
    Type: Application
    Filed: April 11, 2006
    Publication date: October 12, 2006
    Inventors: Gui-Dong Zhu, Virajkumar Gandhi, Jianchun Gong, Thomas Penning, Vincent Giranda, Sheela Thomas
  • 1H-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent PARP inhibitors
    Publication number: 20060229289
    Abstract: Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
    Type: Application
    Filed: April 11, 2006
    Publication date: October 12, 2006
    Inventors: Gui-Dong Zhu, Jianchun Gong, Virajkumar Gandhi, Thomas Penning, Vincent Giranda