Patents by Inventor Vincent J. Idone
Vincent J. Idone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11945872Abstract: The present invention provides monoclonal antibodies that bind to the Activin A type I receptor (ACVR1) protein, and methods of use thereof. In various embodiments of the invention, the antibodies are fully human antibodies that bind to ACVR1. In some embodiments, the antibodies of the invention are useful for inhibiting ACVR1-mediated bone morphogenetic protein (BMP) signal transduction, thus providing a means of treating or preventing a disease, disorder or condition associated with ACVR1.Type: GrantFiled: February 10, 2021Date of Patent: April 2, 2024Assignee: Regeneron Pharmaceuticals, Inc.Inventors: Vincent J. Idone, Sarah J. Hatsell, Aris N. Economides
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Publication number: 20230192831Abstract: The present invention provides antibodies that bind to human gremlin-1 (GREM1), and methods of use. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to GREM1. The antibodies of the invention are useful for inhibiting or neutralizing GREM1 activity, thus providing a means of treating a GREM1-related disease or disorder such as fibrosis and cancer. In some embodiments, the antibodies of the present invention are used in treating at least one symptom or complication of fibrosis of the liver, lungs or kidney.Type: ApplicationFiled: March 6, 2023Publication date: June 22, 2023Inventors: Aris N. Economides, Vincent J. Idone, Lori C. Morton
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Patent number: 11634480Abstract: The present invention provides antibodies that bind to human gremlin-1 (GREM1), and methods of use. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to GREM1. The antibodies of the invention are useful for inhibiting or neutralizing GREM1 activity, thus providing a means of treating a GREM1-related disease or disorder such as fibrosis and cancer. In some embodiments, the antibodies of the present invention are used in treating at least one symptom or complication of fibrosis of the liver, lungs or kidney.Type: GrantFiled: June 27, 2019Date of Patent: April 25, 2023Assignee: Regeneron Pharmaceuticals, Inc.Inventors: Aris N. Economides, Vincent J. Idone, Lori C. Morton
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Publication number: 20220369611Abstract: A genetically modified rodent is provided that comprises a modified Acvr1 gene that comprises a conditional altered exon 7 encoding R258G in antisense orientation, flanked by site-specific recombinase recognition sites, wherein the altered exon is inverted to sense orientation upon action of a recombinase, resulting in ectopic bone formation.Type: ApplicationFiled: July 7, 2022Publication date: November 24, 2022Applicant: Regeneron Pharmaceuticals, Inc.Inventors: Sarah J. HATSELL, Aris N. ECONOMIDES, Christopher SCHOENHERR, Vincent J. IDONE
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Patent number: 11419319Abstract: A genetically modified rodent is provided that comprises a modified Acvr1 gene that comprises a conditional altered exon 7 encoding R258G in anti sense orientation, flanked by site-specific recombinase recognition sites, wherein the altered exon is inverted to sense orientation upon action of a recombinase, resulting in ectopic bone formation.Type: GrantFiled: June 12, 2019Date of Patent: August 23, 2022Assignee: Regeneran Pharmaceuticals, Inc.Inventors: Sarah J. Hatsell, Aris N. Economides, Christopher Schoenherr, Vincent J. Idone
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Publication number: 20220251184Abstract: The present invention provides antibodies that bind to BMP6, and methods of use. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to BMP6. The antibodies of the invention are useful for inhibiting binding of BMP6 to the hemojuvelin receptor, thereby down-regulating transcription and expression of hepcidin, thus providing a means of preventing or treating an iron-deficiency anemia or an iron-deficiency related disorder. In some embodiments, the antibodies of the present invention are used in treating at least one symptom or complication of an iron-deficiency anemia or an iron-deficiency related disorder.Type: ApplicationFiled: June 9, 2020Publication date: August 11, 2022Inventors: Sarah J. Hatsell, Vincent J. Idone, Andrew J. Murphy
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Patent number: 11407822Abstract: Methods for treating Fibrodysplasia Ossificans Progressiva (FOP) are provided. Such methods involve administering to a subject having FOP an effective regime of an activin receptor type 2A (ACVR2A) and/or an activin receptor type 2B (ACVR2B) antagonist or an activin receptor type 1 (ACVR1) antagonist. Antagonists include fusion proteins of one or more extracellular domains (ECDs) of ACVR2A, ACVR2B and/or ACVR1 and the Fc domain of an immunoglobulin heavy chain, and antibodies against ACVR2A, ACVR2B, ACVR1 or Activin A.Type: GrantFiled: September 23, 2019Date of Patent: August 9, 2022Assignee: REGENERON PHARMACEUTICALS, INC.Inventors: Sarah J. Hatsell, Aris N. Economides, Vincent J. Idone
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Publication number: 20210253716Abstract: The present invention provides monoclonal antibodies that bind to the Activin A type I receptor (ACVR1) protein, and methods of use thereof. In various embodiments of the invention, the antibodies are fully human antibodies that bind to ACVR1. In some embodiments, the antibodies of the invention are useful for inhibiting ACVR1-mediated bone morphogenetic protein (BMP) signal transduction, thus providing a means of treating or preventing a disease, disorder or condition associated with ACVR1.Type: ApplicationFiled: February 10, 2021Publication date: August 19, 2021Inventors: Vincent J. IDONE, Sarah J. HATSELL, Aris N. ECONOMIDES
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Publication number: 20210061898Abstract: Methods for treating Fibrodysplasia Ossificans Progressiva (FOP) are provided in which a subject having FOP is administered an effective regime of an antibody against Activin B, BMP9 or BMP10.Type: ApplicationFiled: September 14, 2020Publication date: March 4, 2021Applicant: REGENERON PHARMACEUTICALS, INC.Inventors: Sarah J. Hatsell, Aris N. Economides, Vincent J. Idone
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Publication number: 20200157194Abstract: The present invention provides antibodies that bind to human gremlin-1 (GREM1), and methods of use. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to GREM1. The antibodies of the invention are useful for inhibiting or neutralizing GREM1 activity, thus providing a means of treating a GREM1-related disease or disorder such as fibrosis and cancer. In some embodiments, the antibodies of the present invention are used in treating at least one symptom or complication of fibrosis of the liver, lungs or kidney.Type: ApplicationFiled: June 27, 2019Publication date: May 21, 2020Inventors: Aris N. Economides, Vincent J. Idone, Lori C. Morton
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Publication number: 20200115440Abstract: Methods for treating Fibrodysplasia Ossificans Progressiva (FOP) are provided. Such methods involve administering to a subject having FOP an effective regime of an activin receptor type 2A (ACVR2A) and/or an activin receptor type 2B (ACVR2B) antagonist or an activin receptor type 1 (ACVR1) antagonist. Antagonists include fusion proteins of one or more extracellular domains (ECDs) of ACVR2A, ACVR2B and/or ACVR1 and the Fc domain of an immunoglobulin heavy chain, and antibodies against ACVR2A, ACVR2B, ACVR1 or Activin A.Type: ApplicationFiled: September 23, 2019Publication date: April 16, 2020Applicant: REGENERON PHARMACEUTICALS, INC.Inventors: Sarah J. Hatsell, Aris N. Economides, Vincent J. Idone
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Publication number: 20190380315Abstract: A genetically modified rodent is provided that comprises a modified Acvr1 gene that comprises a conditional altered exon 7 encoding R258G in anti sense orientation, flanked by site-specific recombinase recognition sites, wherein the altered exon is inverted to sense orientation upon action of a recombinase, resulting in ectopic bone formation.Type: ApplicationFiled: June 12, 2019Publication date: December 19, 2019Applicant: Regeneron Pharmaceuticals, Inc.Inventors: Sarah J. HATSELL, Aris N. ECONOMIDES, Christopher SCHOENHERR, Vincent J. IDONE
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Patent number: 10377817Abstract: The present invention provides antibodies that bind to human gremlin-1 (GREM1), and methods of use. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to GREM1. The antibodies of the invention are useful for inhibiting or neutralizing GREM1 activity, thus providing a means of treating a GREM1-related disease or disorder such as fibrosis and cancer. In some embodiments, the antibodies of the present invention are used in treating at least one symptom or complication of fibrosis of the liver, lungs or kidney.Type: GrantFiled: March 7, 2014Date of Patent: August 13, 2019Assignee: Regeneron Pharmaceuticals, Inc.Inventors: Aris N. Economides, Vincent J. Idone, Lori C. Morton
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Publication number: 20190153085Abstract: Methods for treating Fibrodysplasia Ossificans Progressiva (FOP) are provided in which a subject having FOP is administered an effective regime of an antibody against Activin B, BMP9 or BMP10.Type: ApplicationFiled: November 19, 2018Publication date: May 23, 2019Inventors: Sarah J. Hatsell, Aris N. Economides, Vincent J. Idone
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Publication number: 20180111983Abstract: Methods for treating Fibrodysplasia Ossificans Progressiva (FOP) are provided. Such methods involve administering to a subject having FOP an effective regime of an activin receptor type 2A (ACVR2A) and/or an activin receptor type 2B (ACVR2B) antagonist or an activin receptor type 1 (ACVR1) antagonist. Antagonists include fusion proteins of one or more extracellular domains (ECDs) of ACVR2A, ACVR2B and/or ACVR1 and the Fc domain of an immunoglobulin heavy chain, and antibodies against ACVR2A, ACVR2B, ACVR1 or Activin A.Type: ApplicationFiled: August 28, 2017Publication date: April 26, 2018Inventors: Sarah J. Hatsell, Aris N. Economides, Vincent J. Idone
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Publication number: 20160319009Abstract: Methods for treating Fibrodysplasia Ossificans Progressiva (FOP) are provided in which a subject having FOP is administered an effective regime of an antibody against Activin B, BMP9 or BMP10.Type: ApplicationFiled: April 27, 2016Publication date: November 3, 2016Inventors: Sarah J. Hatsell, Aris N. Economides, Vincent J. Idone
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Publication number: 20160075772Abstract: Methods for treating Fibrodysplasia Ossificans Progressiva (FOP) are provided. Such methods involve administering to a subject having FOP an effective regime of an activin receptor type 2A (ACVR2A) and/or an activin receptor type 2B (ACVR2B) antagonist or an activin receptor type 1 (ACVR1) antagonist. Antagonists include fusion proteins of one or more extracellular domains (ECDs) of ACVR2A, ACVR2B and/or ACVR1 and the Fc domain of an immunoglobulin heavy chain, and antibodies against ACVR2A, ACVR2B, ACVR1 or Activin A.Type: ApplicationFiled: September 10, 2015Publication date: March 17, 2016Inventors: Sarah J. Hatsell, Aris N. Economides, Vincent J. Idone
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Publication number: 20160024195Abstract: The present invention provides antibodies that bind to human gremlin-1 (GREM1), and methods of use. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to GREM1. The antibodies of the invention are useful for inhibiting or neutralizing GREM1 activity, thus providing a means of treating a GREM1-related disease or disorder such as fibrosis and cancer. In some embodiments, the antibodies of the present invention are used in treating at least one symptom or complication of fibrosis of the liver, lungs or kidney.Type: ApplicationFiled: March 7, 2014Publication date: January 28, 2016Inventors: Aris N. Economides, Vincent J. Idone, Lori C. Morton