Patents by Inventor Vincent Kalish

Vincent Kalish has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds, methods and pharmaceutical compositions for inhibiting PARP
    Patent number: 8129382
    Abstract: The present invention provides compounds which inhibit poly(ADP-ribose) polymerase (“PARP”), compositions containing these compounds and methods for using these PARP inhibitors to treat, prevent and/or ameliorate the effects of the conditions described herein.
    Type: Grant
    Filed: June 18, 2010
    Date of Patent: March 6, 2012
    Assignee: Eisai Inc.
    Inventors: Vincent Kalish, Jie Zhang, Weizheng Xu, Jia-He Li, Amy D. Xing, Qun Liu
  • Compounds and their uses
    Patent number: 7915280
    Abstract: This invention relates to compounds, pharmaceutical compositions, and methods of using the disclosed compounds for inhibiting PARP.
    Type: Grant
    Filed: August 30, 2005
    Date of Patent: March 29, 2011
    Assignee: Eisai Inc.
    Inventors: Dana Victor Ferraris, Jia-He Li, Vincent Kalish, Jie Zhang
  • Compounds, methods and pharmaceutical compositions for inhibiting PARP
    Patent number: 7750008
    Abstract: The present invention provides compounds which inhibit poly(ADP-ribose) polymerase (“PARP”), compositions containing these compounds and methods for using these PARP inhibitors to treat, prevent and/or ameliorate the effects of the conditions described herein.
    Type: Grant
    Filed: August 13, 2009
    Date of Patent: July 6, 2010
    Assignee: Eisai Inc.
    Inventors: Vincent Kalish, Jie Zhang, Weizheng Xu, Jia-He Li, Amy D. Xing, Qun Liu
  • Compounds, methods and pharmaceutical compositions for inhibiting PARP
    Patent number: 7601719
    Abstract: The present invention provides compounds which inhibit poly(ADP-ribose) polymerase (“PARP”), compositions containing these compounds and methods for using these PARP inhibitors to treat, prevent and/or ameliorate the effects of the conditions described herein.
    Type: Grant
    Filed: October 20, 2008
    Date of Patent: October 13, 2009
    Assignee: Eisai Corporation of North America
    Inventors: Vincent Kalish, Jie Zhang, Weizheng Xu, Jia-He Li, Amy D. Xing, Qun Liu
  • Compounds, methods and pharmaceutical compositions for inhibiting PARP
    Patent number: 7456178
    Abstract: The present invention provides compounds which inhibit poly(ADP-ribose) polymerase (“PARP”), compositions containing these compounds and methods for using these PARP inhibitors to treat, prevent and/or ameliorate the effects of the conditions described herein.
    Type: Grant
    Filed: August 6, 2007
    Date of Patent: November 25, 2008
    Assignee: MGI GP, Inc.
    Inventors: Vincent Kalish, Jie Zhang, Weizheng Xu, Jia-He Li, Amy Dongxia Xing, Qun Liu
  • COMPOUNDS, METHODS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING PARP
    Publication number: 20080058325
    Abstract: The present invention provides compounds which inhibit poly(ADP-ribose) polymerase (“PARP”) compositions containing these compounds and methods for using these PARP inhibitors to treat, prevent and/or ameliorate the effects of the conditions described herein.
    Type: Application
    Filed: August 6, 2007
    Publication date: March 6, 2008
    Applicant: MGI GP, INC.
    Inventors: Vincent Kalish, Jie Zhang, Weizheng Xu, Jia-He Li, Amy Xing, Qun Liu
  • N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors
    Publication number: 20070299107
    Abstract: The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.
    Type: Application
    Filed: March 16, 2007
    Publication date: December 27, 2007
    Inventors: John Toscano, Frederick Brookfield, Andrew Cohen, Stephen Courtney, Lisa Frost, Vincent Kalish
  • Compounds and their uses
    Patent number: 7235557
    Abstract: This invention relates to compounds, pharmaceutical compositions, and methods of using the disclosed compounds for inhibiting PARP.
    Type: Grant
    Filed: February 21, 2006
    Date of Patent: June 26, 2007
    Assignee: MGI GP, Inc.
    Inventors: Dana Victor Ferraris, Jia-He Li, Vincent Kalish, Jie Zhang
  • Substituted 4,9-dihydrocyclopenta{imn}phenanthridine-5-ones derivatives thereof and their uses
    Patent number: 7157452
    Abstract: This invention relates to compounds, pharmaceutical compositions, and methods of using the disclosed compounds for inhibiting PARP.
    Type: Grant
    Filed: December 24, 2002
    Date of Patent: January 2, 2007
    Assignee: MGI GP, Inc.
    Inventors: Jia-He Li, Jie Zhang, Vincent Kalish
  • Compounds and their uses
    Publication number: 20060142266
    Abstract: This invention relates to compounds, pharmaceutical compositions, and methods of using the disclosed compounds for inhibiting PARP.
    Type: Application
    Filed: February 21, 2006
    Publication date: June 29, 2006
    Applicant: MGI GP, Inc.
    Inventors: Dana Ferraris, Jia-He Li, Vincent Kalish, Jie Zhang
  • Compounds and their uses
    Publication number: 20060003987
    Abstract: This invention relates to compounds, pharmaceutical compositions, and methods of using the disclosed compounds for inhibiting PARP.
    Type: Application
    Filed: August 30, 2005
    Publication date: January 5, 2006
    Applicant: Guilford Pharmaceuticals, Inc.
    Inventors: Dana Ferraris, Jia-He Li, Vincent Kalish, Jie Zhang
  • Compounds and their uses
    Publication number: 20050148575
    Abstract: This invention relates to compounds, pharmaceutical compositions, and methods of using the disclosed compounds for inhibiting PARP.
    Type: Application
    Filed: February 28, 2005
    Publication date: July 7, 2005
    Applicant: Guilford Pharmaceuticals Inc.
    Inventors: Dana Ferraris, Jia-He Li, Vincent Kalish, Jie Zhang
  • Inhibitors of dipeptidyl peptidase iv
    Publication number: 20050070719
    Abstract: Novel inhibitors of dipeptidyl peptidase IV (DPP IV), pharmaceutical compositions comprising therapeutically effective amounts of novel inhibitors of DPP IV, and novel methods of treating medical conditions are provided. The novel inhibitors of DPP IV described herein are useful in the treatment of neurological disorders, diabetes, inflammatory disorders such as arthritis, obesity, osteoporosis, and of such other enumerated conditions as can be treated with inhibitors of DPP IV.
    Type: Application
    Filed: December 26, 2002
    Publication date: March 31, 2005
    Inventors: Sergei Belyakov, Gregory Hamilton, David Hurst, Vincent Kalish, Weixing Li, Eric Wang, Douglas Wilkinson, Yong-Qian Wu, Weizheng Xu
  • Compounds, methods and pharmaceutical compositions for inhibiting PARP
    Publication number: 20050020595
    Abstract: The present invention provides compounds which inhibit poly(ADP-ribose) polymerase (“PARP”), compositions containing these compounds and methods for using these PARP inhibitors to treat, prevent and/or ameliorate the effects of the conditions described herein.
    Type: Application
    Filed: May 26, 2004
    Publication date: January 27, 2005
    Inventors: Vincent Kalish, Jie Zhang, Weizheng Xu, Jia-He Li, Amy Xing, Qun Liu
  • Substituted 4,9-dihydrocyclopentaimnphenanthridine-5-ones derivatives thereof and their uses
    Publication number: 20040259900
    Abstract: This invention relates to compounds, pharmaceutical compositions, and methods of using the disclosed compounds for inhibiting PARP.
    Type: Application
    Filed: August 16, 2004
    Publication date: December 23, 2004
    Inventors: Jia-He Li, Jie Zhang, Vincent Kalish
  • Compounds, pharmaceutical compositions, and methods for stimulating neuronal growth and elongation
    Patent number: 6630472
    Abstract: Compounds that inhibit the peptidyl-prolyl isomerase (rotamase) enzyme activity of the FK-506 binding protein (FKBP) and compositions comprising these compounds are described. The FKBP-inhibiting compounds have a bicyclic [3.3.1], [4.3.1] or polycyclic azaamide nucleus. Pharmaceutical compositions containing such compounds help stimulate the outgrowth of neurites in nerve cells and augmenting nerve regeneration. Methods of treating nerve cells with such compositions are useful to promote repair of neuronal damage caused by disease and physical trauma.
    Type: Grant
    Filed: July 16, 1999
    Date of Patent: October 7, 2003
    Assignee: Pfizer Inc
    Inventors: Susumu Katoh, Hiroshi Kawakami, Hiroki Tada, Maria Angelica Linton, Vincent Kalish, John Howard Tatlock, Jesus Ernesto Villafranca