Patents by Inventor Vincent L. Pecoraro

Vincent L. Pecoraro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Selective near-infrared optical imaging of necrotic cells and simultaneous cell fixing and counter staining with metallacrown complexes
    Patent number: 11408893
    Abstract: A method for selective labelling of necrotic cells including incubating the cells in a solution including a Ln(III)Zn16(HA ligand)16 metallacrown complex, wherein the HA ligand is a hydroximate ligand.
    Type: Grant
    Filed: August 21, 2019
    Date of Patent: August 9, 2022
    Assignees: The Regents of the University of Michigan, Centre National De La Recherche Scientifique
    Inventors: Ivana Martinic, Tu Ngoc Nguyen, Svetlana V. Eliseeva, Vincent L. Pecoraro, Stéphane Petoud
  • Dendrimeric metallacrowns
    Patent number: 10927221
    Abstract: Dendrimeric metallacrowns may include a monomeric metallacrown complex or a dimeric metallacrown complex. In an example, the dendrimeric metallacrown includes the monomeric metallacrown complex and a dendron. In this example, the monomeric metallacrown complex includes a central ion, and a metallomacrocycle attached to the central ion. The central ion is selected from the group consisting of a lanthanide ion, a d-block transition metal ion or rare earth metal ion, and an s-block alkali or alkaline earth metal. The metallomacrocycle includes a repeating sub-unit consisting of a metal ion and a ring ligand selected from the group consisting of a hydroxamic acid derivative and an oxime derivative. The dendron is respectively attached to each of the ring ligands of the metallomacrocycle.
    Type: Grant
    Filed: May 3, 2019
    Date of Patent: February 23, 2021
    Assignee: The Regents of the University of Michigan
    Inventors: Vincent L. Pecoraro, Beatriz A. Lopez Bermudez, Svetlana V. Eliseeva, Stephane Petoud
  • SELECTIVE NEAR-INFRARED OPTICAL IMAGING OF NECROTIC CELLS AND SIMULTANEOUS CELL FIXING AND COUNTER STAINING WITH METALLACROWN COMPLEXES
    Publication number: 20200064350
    Abstract: A method for selective labelling of necrotic cells including incubating the cells in a solution including a Ln(III)Zn16(HA ligand)16 metallacrown complex, wherein the HA ligand is a hydroximate ligand.
    Type: Application
    Filed: August 21, 2019
    Publication date: February 27, 2020
    Inventors: Ivana MARTINIC, Tu Ngoc NGUYEN, Svetlana V. ELISEEVA, Vincent L. PECORARO, Stéphane PETOUD
  • Ln(III) and Ga(III) metallacrown complexes
    Patent number: 10562920
    Abstract: The present invention concerns heterometallic metallacrown compounds incorporating Ga(III) and Ln(III) cations, with a templating ligand such as salicylhydroxamic acid or derivatives thereof, wherein said metallacrown contains at least one repeating [—Ga—N—O—] sub-unit where the N—O derives from the templating ligand.
    Type: Grant
    Filed: April 18, 2016
    Date of Patent: February 18, 2020
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Evan R. Trivedi, Vincent L. Pecoraro, Svetlana V. Eliseeva, Stépane Petoud, Chun Y. Chow, Tu Ngoc Nguyen, Jacob Charles Lutter, Ivana Martinic
  • DENDRIMERIC METALLACROWNS
    Publication number: 20190338080
    Abstract: Dendrimeric metallacrowns may include a monomeric metallacrown complex or a dimeric metallacrown complex. In an example, the dendrimeric metallacrown includes the monomeric metallacrown complex and a dendron. In this example, the monomeric metallacrown complex includes a central ion, and a metallomacrocycle attached to the central ion. The central ion is selected from the group consisting of a lanthanide ion, a d-block transition metal ion or rare earth metal ion, and an s-block alkali or alkaline earth metal. The metallomacrocycle includes a repeating sub-unit consisting of a metal ion and a ring ligand selected from the group consisting of a hydroxamic acid derivative and an oxime derivative. The dendron is respectively attached to each of the ring ligands of the metallomacrocycle.
    Type: Application
    Filed: May 3, 2019
    Publication date: November 7, 2019
    Inventors: Vincent L. Pecoraro, Beatriz A. Lopez Bermudez, Svetlana V. Eliseeva, Stephane Petoud
  • Selective near-infrared optical imaging of necrotic cells and simultaneous cell fixing and counter staining with metallacrown complexes
    Patent number: 10458991
    Abstract: In an example of a method for simultaneously fixing and staining cells, the cells are initially incubated in a solution including a Ln(III)Zn16(HA ligand)16 metallacrown complex, wherein the HA ligand is a hydroximate ligand. The incubating cells are exposed to ultraviolet (UV) light. The cells are allowed to continue to incubate in the solution after UV light exposure.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: October 29, 2019
    Assignees: The Regents of the University of Michigan, Centre National de la Recherche Scientifique
    Inventors: Ivana Martinic, Tu Ngoc Nguyen, Svetlana V. Eliseeva, Vincent L. Pecoraro, Stéphane Petoud
  • Selective near-infrared optical imaging of necrotic cells and simultaneous cell fixing and counter staining with metallacrown complexes
    Patent number: 10359430
    Abstract: In an example of a method for simultaneously fixing and staining cells, the cells are initially incubated in a solution including a Ln(III)Zn16(HA ligand)16 metallacrown complex, wherein the HA ligand is a hydroximate ligand. The incubating cells are exposed to ultraviolet (UV) light. The cells are allowed to continue to incubate in the solution after UV light exposure.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: July 23, 2019
    Assignees: The Regents of the University of Michigan, Centre National de la Recherche Scientifique
    Inventors: Ivana Martinic, Tu Ngoc Nguyen, Svetlana V. Eliseeva, Vincent L. Pecoraro, Stéphane Petoud
  • Metallacrown complexes and methods of making the same
    Patent number: 10174057
    Abstract: A metallacrown complex has the formula: Ln(III)[12-MC-4]2[24-MC-8], wherein MC is a metallacrown macrocycle with a repeating sub-unit consisting of a transition metal (M(II)) and a hydroxamic acid (HA) ligand that produces a ligand-based charge transfer state when incorporated into the metallacrown complex. In an example of a method for making the metallacrown complex, a hydroxamic acid (HA) ligand that is to produce a ligand-based charge transfer state when incorporated into the metallacrown complex, a transition metal salt, and a rare-earth salt are dissolved in a solvent to form a solution. A base is added to the solution. The solution is stirred at a predetermined temperature for a predetermined time. The solution is exposed to a purification method to produce crystals of the metallacrown complex.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: January 8, 2019
    Assignees: The Regents of The University of Michigan, Centre National De La Recherche Scientifique
    Inventors: Evan R. Trivedi, Vincent L. Pecoraro, Svetlana V. Eliseeva, Stephane Petoud, Joseph Jankolovits, Alexandra Foucault-Collet, Ivana Martinic
  • SELECTIVE NEAR-INFRARED OPTICAL IMAGING OF NECROTIC CELLS AND SIMULTANEOUS CELL FIXING AND COUNTER STAINING WITH METALLACROWN COMPLEXES
    Publication number: 20180238897
    Abstract: In an example of a method for simultaneously fixing and staining cells, the cells are initially incubated in a solution including a Ln(III)Zn16(HA ligand)16 metallacrown complex, wherein the HA ligand is a hydroximate ligand. The incubating cells are exposed to ultraviolet (UV) light. The cells are allowed to continue to incubate in the solution after UV light exposure.
    Type: Application
    Filed: August 12, 2016
    Publication date: August 23, 2018
    Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Ivana MARTINIC, Tu Ngoc NGUYEN, Svetlana V. ELISEEVA, Vincent L. PECORARO, Stéphane PETOUD
  • LN(III) AND GA(III) METALLACROWN COMPLEXES
    Publication number: 20180127438
    Abstract: The present invention concerns heterometallic metallacrown compounds incorporating Ga(III) and Ln(III) cations, with a templating ligand such as salicylhydroxamic acid or derivatives thereof, wherein said metallacrown contains at least one repeating [—Ga—N—O—] sub-unit where the N—O derives from the templating ligand.
    Type: Application
    Filed: April 18, 2016
    Publication date: May 10, 2018
    Inventors: Evan R. Trivedi, Vincent L. Pecoraro, Svetlana V. Eliseeva, Stépane Petoud, Chun Y, Chow, Tu Ngoc Nguyen, Jacob Charles Lutter, Ivana Martinic
  • METALLACROWN COMPLEXES AND METHODS OF MAKING THE SAME
    Publication number: 20160215001
    Abstract: A metallacrown complex has the formula: Ln(III)[12-MC-4]2[24-MC-8], wherein MC is a metallacrown macrocycle with a repeating sub-unit consisting of a transition metal (M(II)) and a hydroxamic acid (HA) ligand that produces a ligand-based charge transfer state when incorporated into the metallacrown complex. In an example of a method for making the metallacrown complex, a hydroxamic acid (HA) ligand that is to produce a ligand-based charge transfer state when incorporated into the metallacrown complex, a transition metal salt, and a rare-earth salt are dissolved in a solvent to form a solution. A base is added to the solution. The solution is stirred at a predetermined temperature for a predetermined time. The solution is exposed to a purification method to produce crystals of the metallacrown complex.
    Type: Application
    Filed: September 5, 2014
    Publication date: July 28, 2016
    Inventors: Evan R. Trivedi, Vincent L. Pecoraro, Svetlana V. Eliseeva, Stephane Petoud, Joseph Jankolovits, Alexandra Foucault-Collet, Ivana Martinic