Abstract: A method of performing a plurality of synthesis processes of preparing a radiopharmaceutical in series, which method includes carrying out a first synthesis run comprising the steps of: a) providing water containing 18F; b) trapping the 18F from the water provided in step a) on an anion exchange material; c) eluting the trapped 18F from the anion exchange material to a reaction vessel of first radiopharmaceutical synthesis cassette; d) preparing a radiopharmaceutical incorporating the eluted 18F using the first radiopharmaceutical synthesis cassette; where steps a)-d) are repeated in at least one subsequent run using another radiopharmaceutical synthesis cassette; and where the method includes a reconditioning step of treating the anion exchange material with water between two consecutive runs. Other aspects of the invention relate to a device for performing this method, and a cassette for use in the device.

Abstract: A cassette for performing a plurality of synthesis processes of preparing a radiopharmaceutical in series in a synthesizer, includes: at least one manifold provided with a plurality of valves connectable to and operable by the synthesizer; an anion-exchanger comprising an anionic exchange material; an eluent container comprising an eluent; and a recondition container comprising a reconditioning agent.

Abstract: Method for connecting, in a fluid manner, a system (100) for fluid communication comprising a first (10) and a second (20) fluid valve and comprising the following steps:—providing a first (10) and a second (20) fluid valve, —providing a first pipe (60), —inserting each of the ends (61, 62) of the first pipe (60) into each of the fluid valves (10, 20) in order to form a fluid assembly (100), —providing a compression means (1) comprising two ends (2, 3), —positioning said two ends (2, 3) of said compression means (1) on either side of said fluid assembly (100), —applying a compression force onto said fluid assembly (100) via the compression means (1).

Abstract: Method for connecting, in a fluid manner, a system (100) for fluid communication comprising a first (10) and a second (20) fluid valve and comprising the following steps:—providing a first (10) and a second (20) fluid valve,—providing a first pipe (60),—inserting each of the ends (61, 62) of the first pipe (60) into each of the fluid valves (10, 20) in order to form a fluid assembly (100),—providing a compression means (1) comprising two ends (2, 3),—positioning said two ends (2, 3) of said compression means (1) on either side of said fluid assembly (100),—applying a compression force onto said fluid assembly (100) via the compression means (1).

Abstract: A cassette for performing a plurality of synthesis processes of preparing a radiopharmaceutical in series in a synthesizer, includes: at least one manifold provided with a plurality of valves connectable to and operable by the synthesizer; an anion-exchanger comprising an anionic exchange material; an eluent container comprising an eluent; and a recondition container comprising a reconditioning agent.

Abstract: A method of performing a plurality of synthesis processes of preparing a radiopharmaceutical in series includes carrying out a first synthesis run including the steps of: a) providing water containing fluorine-18; b) trapping the fluorine-18 from the water provided in step a) on an anion exchange material; c) eluting the trapped fluorine-18 from the anion exchange material to a reaction vessel of first radiopharmaceutical synthesis cassette; d) preparing a radiopharmaceutical incorporating the eluted fluorine-18 using the first radiopharmaceutical synthesis cassette; where steps a)-d) are repeated in at least one subsequent run using another radiopharmaceutical synthesis cassette; and where the method includes a reconditioning step of the anion exchange material between two consecutive runs. A device for performing this method and a cassette for use in the device are also disclosed.

Abstract: A method of performing a plurality of synthesis processes of preparing a radiopharmaceutical in series includes carrying out a first synthesis run including the steps of: a) providing water containing fluorine-18; b) trapping the fluorine-18 from the water provided in step a) on an anion exchange material; c) eluting the trapped fluorine-18 from the anion exchange material to a reaction vessel of first radiopharmaceutical synthesis cassette; d) preparing a radiopharmaceutical incorporating the eluted fluorine-18 using the first radiopharmaceutical synthesis cassette; where steps a)-d) are repeated in at least one subsequent run using another radiopharmaceutical synthesis cassette; and where the method includes a reconditioning step of the anion exchange material between two consecutive runs. A device for performing this method and a cassette for use in the device are also disclosed.

Abstract: The invention relates to a compressed-air device for controlling valves comprising, in a longitudinal direction, a first vane-type rotary cylinder (1) having a front face (2) as well as a back face (4), said front face (2) being provided with a rotatable head (3), and a second vane-type rotary cylinder (10) having a front face (11) and a back face, said first (1) and second (10) cylinders each being supplied with compressed air by means of a compressed air valve connected to two ports (7, 8; 14, 15) on each of said first and second cylinders.

Abstract: The invention relates to a compressed-air device for controlling valves comprising, in a longitudinal direction, a first vane-type rotary cylinder (1) having a front face (2) as well as a back face (4), said front face (2) being provided with a rotatable head (3), and a second vane-type rotary cylinder (10) having a front face (11) and a back face, said first (1) and second (10) cylinders each being supplied with compressed air by means of a compressed air valve connected to two ports (7, 8; 14, 15) on each of said first and second cylinders.