Patents by Inventor Vincent Luca

Vincent Luca has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11898039
    Abstract: Presented is a method of improving the incorporation of recycled bituminous products by using at least one surfactant as an alternative to the known rejuvenating oils, for the preparation of asphalt mixes containing recycled bituminous products. The use of such alternative surfactant(s) results in better mechanical properties of the asphalt mix, while using smaller amounts of fresh bitumen and greater amounts of recycled bituminous products.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: February 13, 2024
    Assignee: ARKEMA FRANCE
    Inventors: Juan Antonio Gonzalez Leon, Gilles Barreto, Vincent Luca
  • Publication number: 20220348617
    Abstract: Disclosed are compositions and methods for engineered DLL4 proteins. In one aspect, disclosed herein are engineered DLL4 proteins comprising a conservative amino acid substitution at a residue corresponding to residues 28, 107, 143, 194, and 206 as set forth in SEQ ID NO: 1 and further comprising at least one conservative amino acid substitution at residues 256, 257, 271, 280, 301, and 305 as set forth in SEQ ID NO: 1.
    Type: Application
    Filed: May 1, 2020
    Publication date: November 3, 2022
    Inventors: Vincent LUCA, David Gonzalez Perez
  • Publication number: 20220324927
    Abstract: Disclosed are compositions and methods for engineered peptide inhibitors of NLRP3 infiammasome and methods of their use in the treatment of Myelodysplastic Syndromes. In one aspect, disclosed herein are engineered inhibitors of NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome comprising a Helix 2 of POP1 comprising one or more substitutions at residues 18, 21, 22, 25, 26, 28, 29, and/or 30 of POP1 as set forth in SEQ ID NO:1.
    Type: Application
    Filed: May 1, 2020
    Publication date: October 13, 2022
    Inventors: Alan List, Haitao Ji, Vincent Luca
  • Publication number: 20220241335
    Abstract: Disclosed are compositions and methods for engineered Notch ligands for activating Notch signaling, enhancing eh efficacy of adoptive T cell immunotherapy, making a T cell resistant to tumor suppression, and/or treating a cancer. In one aspect, disclosed herein are methods of activating Notch signaling comprising contacting T cells (such as, for example CD8+ T cells, CD4+ T cells, chimeric antigen receptor 15 (CAR) T cells, tumor infiltrating lymphocytes (TILs), and/or marrow infiltrating lymphocytes (MILS)) with a chemically designed Notch ligand.
    Type: Application
    Filed: July 13, 2020
    Publication date: August 4, 2022
    Inventors: Vincent LUCA, Paulo RODRIGUEZ, David GONZALEZ-PEREZ
  • Patent number: 11261250
    Abstract: This disclosure provides compositions and related methods providing targeted cell-specific inhibition of Notch receptor signaling. The disclosure provides a bi-specific molecule with separate domains that target the intended cell-type and the Notch receptor on that cell-type. The disclosure also provides for nucleic acids, vectors, and cells allowing for the expression of the bi-specific fusion molecules. The disclosure also provides related methods of making and using the bi-specific fusion molecule to inhibit Notch signaling in target cells of interest, including for the treatment of diseases characterized by a dysregulation of Notch signaling.
    Type: Grant
    Filed: July 20, 2017
    Date of Patent: March 1, 2022
    Assignees: FRED HUTCHINSON CANCER RESEARCH CENTER, THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Irwin Bernstein, Vincent Luca, Kenan Christopher Garcia
  • Patent number: 11225576
    Abstract: Provided is a composition including at least one bitumen and at least one additive as defined herein. The composition provides emulsions of all types of bitumens, which can be used in the production of cold-poured mixes, having an improved internal strength and a rapid increase in cohesion.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: January 18, 2022
    Assignee: Arkema France
    Inventors: Eric Jorda, Sandrine Ligier, Vincent Luca, Isabelle Birken
  • Publication number: 20190249010
    Abstract: Provided is a composition including at least one bitumen and at least one additive as defined herein. The composition provides emulsions of all types of bitumens, which can be used in the production of cold-poured mixes, having an improved internal strength and a rapid increase in cohesion.
    Type: Application
    Filed: September 14, 2017
    Publication date: August 15, 2019
    Applicant: ARKEMA FRANCE
    Inventors: Eric Jorda, Sandrine Ligier, Vincent Luca, Isabelle Birken
  • Publication number: 20190248894
    Abstract: This disclosure provides compositions and related methods providing targeted cell-specific inhibition of Notch receptor signaling. The disclosure provides a bi-specific molecule with separate domains that target the intended cell-type and the Notch receptor on that cell-type. The disclosure also provides for nucleic acids, vectors, and cells allowing for the expression of the bi-specific fusion molecules. The disclosure also provides related methods of making and using the bi-specific fusion molecule to inhibit Notch signaling in target cells of interest, including for the treatment of diseases characterized by a dysregulation of Notch signaling.
    Type: Application
    Filed: July 20, 2017
    Publication date: August 15, 2019
    Applicants: Fred Hutchinson Cancer Research Center, The Board of Trustees of The Leland Stanford Junior University
    Inventors: Irwin Bernstein, Vincent Luca, Kenan Christopher Garcia
  • Publication number: 20190048191
    Abstract: Presented is a method of improving the incorporation of recycled bituminous products by using at least one surfactant as an alternative to the known rejuvenating oils, for the preparation of asphalt mixes containing recycled bituminous products. The use of such alternative surfactant(s) results in better mechanical properties of the asphalt mix, while using smaller amounts of fresh bitumen and greater amounts of recycled bituminous products.
    Type: Application
    Filed: October 18, 2018
    Publication date: February 14, 2019
    Applicant: ARKEMA FRANCE
    Inventors: Juan Antonio Gonzalez Leon, Gilles Barreto, Vincent Luca
  • Patent number: 10119026
    Abstract: The present invention relates to a method of improving the incorporation of recycled bituminous products by using at least one surfactant as an alternative to the known rejuvenating oils, for the preparation of asphalt mixes containing recycled bituminous products. The use of such alternative surfactant(s) results in better mechanical properties of the asphalt mix, while using smaller amounts of fresh bitumen and greater amounts of recycled bituminous products.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: November 6, 2018
    Assignee: ARKEMA FRANCE
    Inventors: Juan Antonio Gonzalez Leon, Gilles Barreto, Vincent Luca
  • Patent number: 9173769
    Abstract: A reversible leave in contraceptive device includes an obturator having a body with cylindrical configuration, made of a flexible material and including two stabilizing deformable stiffeners that can be folded back along the obtorator body when unactivated, spreading out radially in a fitted situation in the isthmic part of the Fallopian tube. The stiffeners are in opposite positions so as to fit on one side in the isthmic part of the tube (for the distal side) and, on the other (proximal end) on edges of a tubal ostium. A plurality of projecting forms, having a ridged configuration, run along the entire length of the obturator body in a continuous manner from a tapered bulge of the proximal end to a spherical distal end of the head, and block the tubal protect tubal haustrations. The forms cause deformation of the alveoli to block spermatozoa and close off other mucosal folds.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: November 3, 2015
    Assignee: ASPIDE MEDICAL
    Inventor: Vincent Lucas
  • Publication number: 20140230693
    Abstract: The present invention relates to a method of improving the incorporation of recycled bituminous products by using at least one surfactant as an alternative to the known rejuvenating oils, for the preparation of asphalt mixes containing recycled bituminous products. The use of such alternative surfactant(s) results in better mechanical properties of the asphalt mix, while using smaller amounts of fresh bitumen and greater amounts of recycled bituminous products.
    Type: Application
    Filed: October 12, 2012
    Publication date: August 21, 2014
    Applicant: CECA S.A.
    Inventors: Juan Antonio Gonzalez Leon, Gilles Barreto, Vincent Luca
  • Patent number: 8496749
    Abstract: The present invention relates to bitumen additive mixtures, their use and application for the fabrication of asphalt mixtures used in pavement and waterproofing, and more specifically for construction, repair and maintenance of sidewalks, roads, highways, parking lots or airport runaways and service roads and any other rolling surfaces.
    Type: Grant
    Filed: July 6, 2010
    Date of Patent: July 30, 2013
    Assignee: CECA S.A.
    Inventors: Juan Antonio Gonzalez Leon, Gilles Barreto, Vincent Luca, Eric Jorda
  • Publication number: 20130160773
    Abstract: A reversible leave in contraceptive device includes an obturator having a body with cylindrical configuration, made of a flexible material and including two stabilizing deformable stiffeners that can be folded back along the obturator body when unactivated, spreading out radially in a fitted situation in the isthmic part of the Fallopian tube. The stiffeners are in opposite positions so as to fit on one side in the isthmic part of the tube (for the distal side) and, on the other (proximal end) on edges of a tubal ostium. A plurality of projecting forms, having a ridged configuration, run along the entire length of the obturator body in a continuous manner from a tapered bulge of the proximal end to a spherical distal end of the head, and block the tubal protect tubal haustrations. The forms cause deformation of the alveoli to block spermatozoa and close off other mucosal folds.
    Type: Application
    Filed: June 29, 2011
    Publication date: June 27, 2013
    Applicant: ASPIDE MEDICAL
    Inventor: Vincent Lucas
  • Patent number: 8252865
    Abstract: The present invention relates to a bituminous composition comprising at least one bitumen and at least one polycondensate capable of forming a supramolecular assembly comprising one or more associative group(s). The present invention also relates to the use of such bituminous composition for the preparation of asphalt mixtures useful for the coating of rolling surfaces, for the preparation of water-proofing coatings, and the for the preparation of adhesive formulations.
    Type: Grant
    Filed: November 3, 2011
    Date of Patent: August 28, 2012
    Assignee: CECA S.A.
    Inventors: Juan Antonio Gonzalez Leon, Jean-Philippe Gillet, Gilles Barreto, Manuel Hidalgo, Vincent Luca
  • Publication number: 20120046395
    Abstract: The present invention relates to a bituminous composition comprising at least one bitumen and at least one polycondensate capable of forming a supramolecular assembly comprising one or more associative group(s) The present invention also relates to the use of such bituminous composition for the preparation of asphalt mixtures useful for the coating of rolling surfaces, for the preparation of water-proofing coatings, and the for the preparation of adhesive formulations.
    Type: Application
    Filed: November 3, 2011
    Publication date: February 23, 2012
    Applicant: CECA S.A.
    Inventors: Juan Antonio Gonzalez Leon, Jean-Philippe Gillet, Gilles Barreto, Manuel Hidalgo, Vincent Luca
  • Patent number: 8076398
    Abstract: The present invention relates to a bituminous composition comprising at least one bitumen and at least one polycondensate capable of forming a supramolecular assembly comprising one or more associative group(s). The present invention also relates to the use of such bituminous composition for the preparation of asphalt mixtures useful for the coating of rolling surfaces, for the preparation of water-proofing coatings, and the for the preparation of adhesive formulations.
    Type: Grant
    Filed: August 3, 2010
    Date of Patent: December 13, 2011
    Assignee: Ceca S.A.
    Inventors: Juan Antonio Gonzalez Leon, Jean-Philippe Gillet, Gilles Barreto, Manuel Hidalgo, Vincent Luca
  • Publication number: 20110034593
    Abstract: The present invention relates to a bituminous composition comprising at least one bitumen and at least one polycondensate capable of forming a supramolecular assembly comprising one or more associative group(s). The present invention also relates to the use of such bituminous composition for the preparation of asphalt mixtures useful for the coating of rolling surfaces, for the preparation of water-proofing coatings, and the for the preparation of adhesive formulations.
    Type: Application
    Filed: August 3, 2010
    Publication date: February 10, 2011
    Applicant: CECA S.A.
    Inventors: Juan Antonio Gonzalez Leon, Jean-Philippe Gillet, Gilles Barreto, Manuel Hidalgo, Vincent Luca
  • Publication number: 20110005429
    Abstract: The present invention relates to bitumen additive mixtures, their use and application for the fabrication of asphalt mixtures used in pavement and waterproofing, and more specifically for construction, repair and maintenance of sidewalks, roads, highways, parking lots or airport runaways and service roads and any other rolling surfaces.
    Type: Application
    Filed: July 6, 2010
    Publication date: January 13, 2011
    Applicant: CECA S.A.
    Inventors: Juan Antonio Gonzalez Leon, Gilles Barreto, Vincent Luca, Eric Jorda
  • Patent number: 4522458
    Abstract: A frangible pin (15) extends radially between interfitted first and second shell portions (21, 26) comprising an electrical connector assembly, the pin having a cross-sectional area sized to shear upon application of an external force so that the shells can break-away from one another.
    Type: Grant
    Filed: May 11, 1983
    Date of Patent: June 11, 1985
    Assignee: Allied Corporation
    Inventors: Dee A. Werth, Vincent A. Luca, Jr.