Abstract: A training system includes: a model; and a training module configured to: construct a first pair of images of at least a first portion of a first human captured at different times; construct a second pair of images of at least a second portion of a second human captured at the same time from different points of view; input the first and second pairs of images to the model; the model configured to: generate first and second reconstructed images of the at least the first portion of the first human based on the first and second pairs, respectively, and the training module is configured to selectively adjust one or more parameters of the model based on: the first reconstructed image and the second reconstructed image.

Abstract: The present invention relates to a method of improving the incorporation of recycled bituminous products by using at least one surfactant as an alternative to the known rejuvenating oils, for the preparation of asphalt mixes containing recycled bituminous products. The use of such alternative surfactant(s) results in better mechanical properties of the asphalt mix, while using smaller amounts of fresh bitumen and greater amounts of recycled bituminous products.

Abstract: A method includes: performing unsupervised pre-training of a model, the model including and a decoder including: obtaining a first image and a second image under different conditions or from different viewpoints; encoding, by the encoder, the first image into a representation of the first image and the second image into a representation of the second image; transforming the representation of the first image into a transformed representation; decoding, by the decoder, the transformed representation into a reconstructed image, where the transforming of the representation of the first image and the decoding of the transformed representation is based on the representation of the first image and the representation of the second image; and adjusting one or more parameters of at least one of the encoder and the decoder based on minimizing a loss; and fine-tuning the model, initialized with a set of task specific encoder parameters, for a geometric vision task.

Abstract: Presented is a method of improving the incorporation of recycled bituminous products by using at least one surfactant as an alternative to the known rejuvenating oils, for the preparation of asphalt mixes containing recycled bituminous products. The use of such alternative surfactant(s) results in better mechanical properties of the asphalt mix, while using smaller amounts of fresh bitumen and greater amounts of recycled bituminous products.

Abstract: Disclosed are compositions and methods for engineered DLL4 proteins. In one aspect, disclosed herein are engineered DLL4 proteins comprising a conservative amino acid substitution at a residue corresponding to residues 28, 107, 143, 194, and 206 as set forth in SEQ ID NO: 1 and further comprising at least one conservative amino acid substitution at residues 256, 257, 271, 280, 301, and 305 as set forth in SEQ ID NO: 1.

Abstract: Disclosed are compositions and methods for engineered peptide inhibitors of NLRP3 infiammasome and methods of their use in the treatment of Myelodysplastic Syndromes. In one aspect, disclosed herein are engineered inhibitors of NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome comprising a Helix 2 of POP1 comprising one or more substitutions at residues 18, 21, 22, 25, 26, 28, 29, and/or 30 of POP1 as set forth in SEQ ID NO:1.

Abstract: Disclosed are compositions and methods for engineered Notch ligands for activating Notch signaling, enhancing eh efficacy of adoptive T cell immunotherapy, making a T cell resistant to tumor suppression, and/or treating a cancer. In one aspect, disclosed herein are methods of activating Notch signaling comprising contacting T cells (such as, for example CD8+ T cells, CD4+ T cells, chimeric antigen receptor 15 (CAR) T cells, tumor infiltrating lymphocytes (TILs), and/or marrow infiltrating lymphocytes (MILS)) with a chemically designed Notch ligand.

Abstract: This disclosure provides compositions and related methods providing targeted cell-specific inhibition of Notch receptor signaling. The disclosure provides a bi-specific molecule with separate domains that target the intended cell-type and the Notch receptor on that cell-type. The disclosure also provides for nucleic acids, vectors, and cells allowing for the expression of the bi-specific fusion molecules. The disclosure also provides related methods of making and using the bi-specific fusion molecule to inhibit Notch signaling in target cells of interest, including for the treatment of diseases characterized by a dysregulation of Notch signaling.

Abstract: Provided is a composition including at least one bitumen and at least one additive as defined herein. The composition provides emulsions of all types of bitumens, which can be used in the production of cold-poured mixes, having an improved internal strength and a rapid increase in cohesion.

Abstract: Provided is a composition including at least one bitumen and at least one additive as defined herein. The composition provides emulsions of all types of bitumens, which can be used in the production of cold-poured mixes, having an improved internal strength and a rapid increase in cohesion.

Abstract: This disclosure provides compositions and related methods providing targeted cell-specific inhibition of Notch receptor signaling. The disclosure provides a bi-specific molecule with separate domains that target the intended cell-type and the Notch receptor on that cell-type. The disclosure also provides for nucleic acids, vectors, and cells allowing for the expression of the bi-specific fusion molecules. The disclosure also provides related methods of making and using the bi-specific fusion molecule to inhibit Notch signaling in target cells of interest, including for the treatment of diseases characterized by a dysregulation of Notch signaling.

Abstract: Presented is a method of improving the incorporation of recycled bituminous products by using at least one surfactant as an alternative to the known rejuvenating oils, for the preparation of asphalt mixes containing recycled bituminous products. The use of such alternative surfactant(s) results in better mechanical properties of the asphalt mix, while using smaller amounts of fresh bitumen and greater amounts of recycled bituminous products.

Abstract: The present invention relates to a method of improving the incorporation of recycled bituminous products by using at least one surfactant as an alternative to the known rejuvenating oils, for the preparation of asphalt mixes containing recycled bituminous products. The use of such alternative surfactant(s) results in better mechanical properties of the asphalt mix, while using smaller amounts of fresh bitumen and greater amounts of recycled bituminous products.

Abstract: A reversible leave in contraceptive device includes an obturator having a body with cylindrical configuration, made of a flexible material and including two stabilizing deformable stiffeners that can be folded back along the obtorator body when unactivated, spreading out radially in a fitted situation in the isthmic part of the Fallopian tube. The stiffeners are in opposite positions so as to fit on one side in the isthmic part of the tube (for the distal side) and, on the other (proximal end) on edges of a tubal ostium. A plurality of projecting forms, having a ridged configuration, run along the entire length of the obturator body in a continuous manner from a tapered bulge of the proximal end to a spherical distal end of the head, and block the tubal protect tubal haustrations. The forms cause deformation of the alveoli to block spermatozoa and close off other mucosal folds.

Abstract: The present invention relates to a method of improving the incorporation of recycled bituminous products by using at least one surfactant as an alternative to the known rejuvenating oils, for the preparation of asphalt mixes containing recycled bituminous products. The use of such alternative surfactant(s) results in better mechanical properties of the asphalt mix, while using smaller amounts of fresh bitumen and greater amounts of recycled bituminous products.

Abstract: The present invention relates to bitumen additive mixtures, their use and application for the fabrication of asphalt mixtures used in pavement and waterproofing, and more specifically for construction, repair and maintenance of sidewalks, roads, highways, parking lots or airport runaways and service roads and any other rolling surfaces.

Abstract: A reversible leave in contraceptive device includes an obturator having a body with cylindrical configuration, made of a flexible material and including two stabilizing deformable stiffeners that can be folded back along the obturator body when unactivated, spreading out radially in a fitted situation in the isthmic part of the Fallopian tube. The stiffeners are in opposite positions so as to fit on one side in the isthmic part of the tube (for the distal side) and, on the other (proximal end) on edges of a tubal ostium. A plurality of projecting forms, having a ridged configuration, run along the entire length of the obturator body in a continuous manner from a tapered bulge of the proximal end to a spherical distal end of the head, and block the tubal protect tubal haustrations. The forms cause deformation of the alveoli to block spermatozoa and close off other mucosal folds.

Abstract: The present invention relates to a bituminous composition comprising at least one bitumen and at least one polycondensate capable of forming a supramolecular assembly comprising one or more associative group(s). The present invention also relates to the use of such bituminous composition for the preparation of asphalt mixtures useful for the coating of rolling surfaces, for the preparation of water-proofing coatings, and the for the preparation of adhesive formulations.

Abstract: The present invention relates to a bituminous composition comprising at least one bitumen and at least one polycondensate capable of forming a supramolecular assembly comprising one or more associative group(s) The present invention also relates to the use of such bituminous composition for the preparation of asphalt mixtures useful for the coating of rolling surfaces, for the preparation of water-proofing coatings, and the for the preparation of adhesive formulations.

Abstract: The present invention relates to a bituminous composition comprising at least one bitumen and at least one polycondensate capable of forming a supramolecular assembly comprising one or more associative group(s). The present invention also relates to the use of such bituminous composition for the preparation of asphalt mixtures useful for the coating of rolling surfaces, for the preparation of water-proofing coatings, and the for the preparation of adhesive formulations.