Patents by Inventor Vincent M. Rotello

Vincent M. Rotello has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Generation of stable protein films using fluorous solvent
    Patent number: 11884946
    Abstract: Methods of preparing protein films in the presence of organofluorine compounds are provided that can produce protein films that retain the solution phase characteristics of the proteins. The protein films can be coatings for medical devices.
    Type: Grant
    Filed: November 5, 2018
    Date of Patent: January 30, 2024
    Assignee: University of Massachusetts
    Inventors: Li-Sheng Wang, Sanjana Gopalakrishnan, Vincent M. Rotello
  • CROSSLINKED PARTICLES, COMPOSITION COMPRISING THE CROSSLINKED PARTICLES, METHOD FOR THE MANUFACTURE THEREOF, AND METHOD OF TREATING AN INFECTION
    Publication number: 20230149514
    Abstract: Crosslinked particles including an essential oil and gelatin are described. At least a portion of the gelatin is crosslinked. A method of making the crosslinked particles includes emulsifying a mixture of an essential oil and an aqueous solution, and exposing the resulting particles to conditions effective to crosslink the gelatin to provide the crosslinked particles. The crosslinked particles and compositions including the crosslinked particles can be particularly useful in the treatment of bacterial and fungal infections.
    Type: Application
    Filed: January 20, 2023
    Publication date: May 18, 2023
    Inventors: Vincent M. Rotello, Ryan Francis Landis
  • POLYMER NANOPARTICLE, POLYMER COMPOSITION, METHOD OF MAKING A POLYMER NANOPARTICLE, METHOD FOR TREATMENT OF BACTERIAL BIOFILMS, AND METHOD FOR DETECTION OF BACTERIAL BIOFILMS
    Publication number: 20220184115
    Abstract: A polymer nanoparticle includes a polymer having repeating units of formula (I) wherein X, L1, and R1 are as defined herein. Methods of preparing the polymer nanoparticles and compositions comprising the nanoparticles are also disclosed. The polymers nanoparticles described herein are particularly useful for the treatment of bacterial biofilms.
    Type: Application
    Filed: February 16, 2022
    Publication date: June 16, 2022
    Inventors: Vincent M. Rotello, Ryan Francis Landis, Akash Gupta
  • Polymer nanoparticle, polymer composition, method of making a polymer nanoparticle, method for treatment of bacterial biofilms, and method for detection of bacterial biofilms
    Patent number: 11291685
    Abstract: A polymer nanoparticle includes a polymer having repeating units of formula (I) wherein X, L1, and R1 are as defined herein. Methods of preparing the polymer nanoparticles and compositions comprising the nanoparticles are also disclosed. The polymers nanoparticles described herein are particularly useful for the treatment of bacterial biofilms.
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: April 5, 2022
    Assignee: THE UNIVERSITY OF MASSACHUSETTS
    Inventors: Vincent M. Rotello, Ryan Francis Landis, Akash Gupta
  • CROSSLINKED PARTICLES, COMPOSITION COMPRISING THE CROSSLINKED PARTICLES, METHOD FOR THE MANUFACTURE THEREOF, AND METHOD OF TREATING AN INFECTION
    Publication number: 20200306347
    Abstract: Crosslinked particles including an essential oil and gelatin are described. At least a portion of the gelatin is crosslinked. A method of making the crosslinked particles includes emulsifying a mixture of an essential oil and an aqueous solution, and exposing the resulting particles to conditions effective to crosslink the gelatin to provide the crosslinked particles. The crosslinked particles and compositions including the crosslinked particles can be particularly useful in the treatment of bacterial and fungal infections.
    Type: Application
    Filed: December 11, 2018
    Publication date: October 1, 2020
    Inventors: Vincent M. Rotello, Ryan Francis Landis
  • Nanoparticle-protein complex for intracellular protein delivery
    Patent number: 10787523
    Abstract: Various embodiments disclosed relate to a nanoparticle-protein complex for intracellular protein delivery. In various embodiments, the present invention provides a nanoparticle-protein complex including a nanoparticle including an amine-containing ligand. The nanoparticle-protein complex also includes a protein comprising a carboxylic acid-containing tag.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: September 29, 2020
    Assignee: University of Massachusetts
    Inventors: Vincent M. Rotello, Rubul Mout
  • Nanoparticle-stabilized nanocapsules and methods of preparation and use for nucleic acid delivery
    Patent number: 10786527
    Abstract: The invention provides nanoparticle-stabilized nanocapsules, and methods of their preparation and use in delivery of therapeutics, such as nucleic acids. Various embodiments disclosed relate to a nanoparticle-stabilized nanocapsule. Various embodiments disclosed relate to nanoparticle-stabilized nanocapsules for nucleic acid delivery into cells. Various embodiments provide methods of using the nanocapsule for in vivo delivery of the nucleic acid materials.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: September 29, 2020
    Assignee: University of Massachusetts
    Inventors: Vincent M. Rotello, Ying Jiang, Rui Tang
  • Stabilized polymeric nanocapsules, dispersions comprising the nanocapsules, and methods for the treatment of bacterial biofilms
    Patent number: 10493039
    Abstract: A nanocapsule includes a liquid hydrophobic care including an essential oil, and a shell encapsulating the core. The shell includes a copolymer having repeating units of Formula (I) and (II) wherein X, L1, R1, R2, y, and p are as described herein. A dispersion is also disclosed, wherein the dispersion includes a plurality of nanocapsules. The nanocapsules described herein are particularly useful for the treatment of bacterial biofilms.
    Type: Grant
    Filed: August 16, 2016
    Date of Patent: December 3, 2019
    Assignee: THE UNIVERSITY OF MASSACHUSETTS
    Inventors: Vincent M. Rotello, Ryan Francis Landis, Akash Gupta, Yiwei Lee
  • POLYMER NANOPARTICLE, POLYMER COMPOSITION, METHOD OF MAKING A POLYMER NANOPARTICLE, METHOD FOR TREATMENT OF BACTERIAL BIOFILMS, AND METHOD FOR DETECTION OF BACTERIAL BIOFILMS
    Publication number: 20190175642
    Abstract: A polymer nanoparticle includes a polymer having repeating units of formula (I) wherein X, L1, and R1 are as defined herein. Methods of preparing the polymer nanoparticles and compositions comprising the nanoparticles are also disclosed. The polymers nanoparticles described herein are particularly useful for the treatment of bacterial biofilms.
    Type: Application
    Filed: July 28, 2017
    Publication date: June 13, 2019
    Applicant: THE UNIVERSITY OF MASSACHUSETTS
    Inventors: Vincent M. Rotello, Ryan Francis Landis, Akash Gupta
  • GENERATION OF STABLE PROTEIN FILMS USING FLUOROUS SOLVENT
    Publication number: 20190136214
    Abstract: Methods of preparing protein films in the presence of organofluorine compounds are provided that can produce protein films that retain the solution phase characteristics of the proteins. The protein films can be coatings for medical devices.
    Type: Application
    Filed: November 5, 2018
    Publication date: May 9, 2019
    Inventors: Li-Sheng Wang, Sanjana Gopalakrishnan, Vincent M. Rotello
  • Nanoparticle-stabilized microcapsules, dispersions comprising nanoparticle-stabilized microcapsules, and method for the treatment of bacterial biofilms
    Patent number: 10272126
    Abstract: A stabilized microcapsule includes a liquid hydrophobic core including an essential oil and an aromatic monoaldehyde, and a shell encapsulating the core, the shell including a plurality of amino-functionalized inorganic nanoparticles. Also disclosed is a dispersion including a plurality of the stabilized microcapsules. The microcapsules and dispersions can be particularly useful for treating a bacterial biofilm.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: April 30, 2019
    Assignee: THE UNIVERSITY OF MASSACHUSETTS
    Inventors: Bradley Duncan, Xiaoning Li, Vincent M. Rotello
  • Protein films and methods of forming the same
    Patent number: 10073340
    Abstract: Various embodiments disclosed relate to protein films and methods of making the same. In various embodiments, the present invention provides a method of making a protein film including placing on a substrate a protein solution, to form a precursor protein film. The protein solution includes one or more proteins. The method includes compressing the precursor protein film to form a protein film.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: September 11, 2018
    Assignee: University of Massachusetts
    Inventors: Vincent M Rotello, Bradley Duncan, Li-Sheng Wang, Eunhee Jeoung, Chandramouleeswaran Subramani, Krishnendu Saha
  • STABILIZED POLYMERIC NANOCAPSULES, DISPERSIONS COMPRISING THE NANOCAPSULES, AND METHODS FOR THE TREATMENT OF BACTERIAL BIOFILMS
    Publication number: 20180177738
    Abstract: A nanocapsule includes a liquid hydrophobic care including an essential oil, and a shell encapsulating the core. The shell includes a copolymer having repeating units of Formula (I) and (II) wherein X, L1, R1, R2, y, and p are as described herein. A dispersion is also disclosed, wherein the dispersion includes a plurality of nanocapsules. The nanocapsules described herein are particularly useful for the treatment of bacterial biofilms.
    Type: Application
    Filed: August 16, 2016
    Publication date: June 28, 2018
    Inventors: Vincent M. Rotello, Ryan Francis Landis, Akash Gupta, Yiwei Lee
  • POLYMER NANOCAPSULES FOR PROTEIN DELIVERY
    Publication number: 20180125791
    Abstract: A nanocapsule includes a shell including a polymer and a protein, a nucleic acid, or a combination thereof. The polymer has repeating units of Formula (I) (I) wherein X, L1, R1, and y are as described herein. The nanocapsule further includes a core comprising an oil. A composition is also disclosed including a plurality of the nanocapsules dispersed in an aqueous solution. The nanocapsules prepared according to the methods described herein are particularly useful for the delivery of proteins and nucleic acids into cells.
    Type: Application
    Filed: May 10, 2016
    Publication date: May 10, 2018
    Inventors: Vincent M. Rotello, Ryan F. Landis, Moumita Ray
  • NANOPARTICLE-PROTEIN COMPLEX FOR INTRACELLULAR PROTEIN DELIVERY
    Publication number: 20180022831
    Abstract: Various embodiments disclosed relate to a nanoparticle-protein complex for intracellular protein delivery. In various embodiments, the present invention provides a nanoparticle-protein complex including a nanoparticle including an amine-containing ligand. The nanoparticle-protein complex also includes a protein comprising a carboxylic acid-containing tag.
    Type: Application
    Filed: January 29, 2016
    Publication date: January 25, 2018
    Inventors: Vincent M. Rotello, Rubul Mout
  • Maleic anhydride polymer-stabilized microcapsules
    Patent number: 9849435
    Abstract: The present invention relates to microcapsules with a core-shell or matrix morphology stabilized by cross-linked nanoparticles. A process for the preparation of said microcapsules comprising selecting internal crosslinking of a Pickering emulsion is also an object of the invention. Perfumed consumer products, in particular fine fragrance, home and personal care products are also part of the invention.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: December 26, 2017
    Assignee: Firmenich SA
    Inventors: Vincent M. Rotello, Bradley P. Duncan, Valery Normand, Huda Jerri, Lahoussine Ouali, Daniel Benczedi
  • NANOPARTICLE-STABILIZED NANOCAPSULES AND METHODS OF PREPARATION AND USE FOR NUCLEIC ACID DELIVERY
    Publication number: 20170119687
    Abstract: The invention provides nanoparticle-stabilized nanocapsules, and methods of their preparation and use in delivery of therapeutics, such as nucleic acids. Various embodiments disclosed relate to a nanoparticle-stabilized nanocapsule. Various embodiments disclosed relate to nanoparticle-stabilized nanocapsules for nucleic acid delivery into cells. Various embodiments provide methods of using the nanocapsule for in vivo delivery of the nucleic acid materials.
    Type: Application
    Filed: March 18, 2016
    Publication date: May 4, 2017
    Inventors: Vincent M. Rotello, Ying Jiang, Rui Tang
  • NANOPARTICLE-STABILIZED MICROCAPSULES, DISPERSIONS COMPRISING NANOPARTICLE-STABILIZED MICROCAPSULES, AND METHOD FOR THE TREATMENT OF BACTERIAL BIOFILMS
    Publication number: 20170049113
    Abstract: A stabilized microcapsule includes a liquid hydrophobic core including an essential oil and an aromatic monoaldehyde, and a shell encapsulating the core, the shell including a plurality of amino-functionalized inorganic nanoparticles. Also disclosed is a dispersion including a plurality of the stabilized microcapsules. The microcapsules and dispersions can be particularly useful for treating a bacterial biofilm.
    Type: Application
    Filed: July 21, 2016
    Publication date: February 23, 2017
    Inventors: Bradley Duncan, Xiaoning Li, Vincent M. Rotello
  • PARTICLE-STABILIZED MICROCAPSULES
    Publication number: 20160317993
    Abstract: The present invention relates to microcapsules with a core-shell or matrix morphology stabilized by cross-linked nanoparticles. A process for the preparation of said microcapsules comprising selecting internal crosslinking of a Pickering emulsion is also an object of the invention. Perfumed consumer products, in particular fine fragrance, home and personal care products are also part of the invention.
    Type: Application
    Filed: December 18, 2014
    Publication date: November 3, 2016
    Applicants: Firmenich SA, UNIVERSITY OF MASSACHUSSETTS
    Inventors: Vincent M. ROTELLO, Bradley P. DUNCAN, Valery NORMAND, Huda JERRI, Lahoussine OUALI, Daniel BENCZEDI
  • PROTEIN FILMS AND METHODS OF FORMING THE SAME
    Publication number: 20160096935
    Abstract: Various embodiments disclosed relate to protein films and methods of making the same. In various embodiments, the present invention provides a method of making a protein film including placing on a substrate a protein solution, to form a precursor protein film. The protein solution includes one or more proteins. The method includes compressing the precursor protein film to form a protein film.
    Type: Application
    Filed: October 2, 2015
    Publication date: April 7, 2016
    Inventors: Vincent M. Rotello, Bradley Duncan, Li-Sheng Wang, Eunhee Jeoung, Chandramouleeswaran Subramani, Krishnendu Saha