Abstract: A nanopore conductance measurement method and system is provided. The system has reservoirs of conductive fluid separated by a resistive barrier, which is perforated by a single nanometer scale pore commensurate in size with an analyte molecule in at least one of the reservoirs. The system is configured to have an ionic current driven across the reservoirs by an applied potential and the pore may be treated so that the pore surface can form associations with the analyte molecules of interest to increase the analyte molecule residence times on or in the pore. The system also comprises a means of measuring the ionic current, which current may be either direct or alternating in time, induced by an applied potential between electrodes in the conductive fluid, on each side of the barrier.

Abstract: A continuous speech recognition and voice response system provides a natural sounding and effective interactive, speech-driven dialogue from a data processing system. A concatenation of words into phrases and sentences improves recognition and mimic natural language processing. The system uses speaker-independent, continuous-speech to initiate the playback of audio files. The system employs high-speed context switching to modify the active vocabulary and applies high-speed context switching to modify or activate Audio WAV voice response files. The system uses dialogue history to activate selected context, Baukus-Naur Form (BNF) grammars and WAV files and provides phrase or sentence long dialogue prompts to improve accuracy. The system also provides audio prompts to improve accuracy and provides speech-activated buttons to navigate between menus.

Abstract: A digitized speech data channel is analyzes for the presence of words or phrases from a desired list. If the word is not present the speech time series from the channel, there is a high probability of matching the input data to phonemic noise markers rather than to word models. This is accomplished through the use of a competitive algorithm wherein Hidden Markov Models (HMMs) of the desired words or phrases compete with an alternative HMM of a set of phonemes. The set of phonemes can be chosen in order to reduce the computer resources required for the channel analysis.