Patents by Inventor Vincent P. Gullo
Vincent P. Gullo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5776912Abstract: An aqueous pharmaceutical composition comprising a lipophilic oligosaccharide antibiotic salt, e.g., the N-methylglucamine salt of the everninomicin-type antibiotic of Formula III together with a binding agent such as human serum albumin or recombinant human albumin and a tonicity agent such as mannitol, is disclosed.Type: GrantFiled: December 20, 1996Date of Patent: July 7, 1998Assignee: Schering CorporationInventors: Mahesh G. Patel, Vincent P. Gullo, Roberta S. Hare, David Loebenberg, Heewon Y. Kwon, George H. Miller
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Patent number: 5624914Abstract: Pharmaceutically acceptable compositions of matter comprising a lipophilic oligosaccharide antibiotic, e.g., the everninomicin-type antibiotic of Formula III, at least a stoichiometric amount of a base, e.g., N-methylglucamine, an amount of, e.g., hydroxypropyl-.beta.-cyclodextrin, and optionally a pharmaceutically acceptable non-ionic surfactant, e.g., Tween-80, pharmaceutical compositions containing such compositions of matter, methods of treating and preventing susceptible bacterial infections in animals especially human beings as well as a method of preventing adverse reaction syndrome while simultaneously delivering an antiinfective amount of a lipophilic oligosaccharide antibiotic such as that of Formula III to said animals as well as the use of the compositions of matter for the preparation of a medicament for such treating or preventing are disclosed.Type: GrantFiled: April 12, 1994Date of Patent: April 29, 1997Assignee: Schering CorporationInventors: Mahesh Patel, Vincent P. Gullo, Roberta Hare, David Loebenberg, James B. Morton, George H. Miller, Heewon Y. Kwon
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Patent number: 5449685Abstract: A method of treating mammals infected with HIV-1, or AIDS by administering a therapeutically effective amount of a compound represented by formula I ##STR1## or a pharmaceutically acceptable salt or ester thereof or stereoisomer thereof and pharmaceutical compositions containing it are disclosed.Type: GrantFiled: October 23, 1992Date of Patent: September 12, 1995Assignee: Schering CorporationInventors: Mahesh G. Patel, Vincent P. Gullo, Jerome Schwartz
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Patent number: 5446207Abstract: Compounds of the formula: ##STR1## wherein a is a single bond and b is a double bond; or a is a double bond and b is a single bond; and enantiomers thereof; or a pharmaceutically acceptable salt thereof are described. These compounds can improve lipoprotein profile of dyslipidemic patients and generate an anti-atherogenic lipoprotein profile of normolipidemic individuals. In addition, inhibition of CETP activity may be useful as antifertility agents.Type: GrantFiled: September 1, 1993Date of Patent: August 29, 1995Assignee: Harbor Branch Oceanographic Institution, Inc.Inventors: Shirley A. Pomponi, Vincent P. Gullo, Ann C. Horan, Mahesh G. Patel, Stephen J. Coval
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Patent number: 5352707Abstract: A method for treating airway congestion which comprises administering an effective amount of the compound of formula II which follows ##STR1## or a pharmaceutically acceptable salt thereof.Type: GrantFiled: March 26, 1992Date of Patent: October 4, 1994Assignee: Harbor Branch Oceanographic Institution, Inc.Inventors: Shirley A. Pompni, Vincent P. Gullo, Ann C. Horan, Mahesh G. Patel, Stephen Coval
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Patent number: 5338758Abstract: Four bicyclic terpenes isolated from a culture broth of Phoma sp SCF0592, ATCC 74077, pharmaceutical compositions containing them and their use as PAF antagonists to treat allergic and inflammatory diseases are disclosed.Type: GrantFiled: September 30, 1992Date of Patent: August 16, 1994Assignee: Schering CorporationInventors: Min Chu, Mahesh Patel, Ann C. Horan, Vincent P. Gullo
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Patent number: 5217986Abstract: The compound of the formula ##STR1## is described. This compound is active in an H.sub.3 receptor assay and is an H.sub.3 antagonist. Accordingly, the compound of formula I is useful in the treatment of diseases and conditions such as asthma, rhinitis, airway congestion, inflammation, cardiac arrhythmias, hypertension, hyper and hypo motility and acid secretion of the gastrointestinal tract, hypo and hyper activity of the central nervous system (CNS), migraine, and glaucoma.Type: GrantFiled: March 26, 1992Date of Patent: June 8, 1993Assignee: Harbor Branch Oceanographic Institution, Inc.Inventors: Shirley A. Pomponi, Vincent P. Gullo, Ann C. Horan, Mahesh G. Patel, Stephen Coval
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Patent number: 4432996Abstract: Substances isolated after cultivation of a micoorganism belonging to the genus Penicillium in a culture medium comprises compounds which have strucures: ##STR1## Together with salts and esters of the carboxylic acid, these compounds form a class of highly active hypocholesterolemic and hypolipemic medicaments.Type: GrantFiled: May 17, 1982Date of Patent: February 21, 1984Assignee: Merck & Co., Inc.Inventors: Vincent P. Gullo, Tony Y. K. Lam, Richard L. Monaghan
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Patent number: 4378353Abstract: There are disclosed certain new compounds related to C-076 compounds which have been produced by a mutant of the culture that produced the original C-076 compounds and isolated from the fermentation broth thereof. The compounds retain the C-076 16-membered cyclic backbone, however, the groups attached thereto are considerably modified from the original C-076 compounds. The new compounds have been found to retain the biological activity of the parent C-076 compounds. The compounds are thus potent antiparasitic agents and compositions and methods for such uses are also disclosed.Type: GrantFiled: February 17, 1981Date of Patent: March 29, 1983Assignee: Merck & Co., Inc.Inventors: Robert T. Goegelman, Vincent P. Gullo, Louis Kaplan
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Patent number: 4343814Abstract: Substances isolated after cultivation of a microorganism belonging to the genus Penicillium in a culture medium comprises compounds which have structures: ##STR1## Together with salts and esters of the carboxylic acid, these compounds form a class of highly active hypocholesterolemic and hypolipemic medicaments.Type: GrantFiled: November 17, 1980Date of Patent: August 10, 1982Assignee: Merck & Co., Inc.Inventors: Vincent P. Gullo, Tony Y. K. Lam, Richard L. Monaghan
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Patent number: 4311693Abstract: The antibiotic MSD A63A, having antibacterial and growth-permittant activity, is produced by fermentation of Streptoverticillum hiroshimense MA4845 (ATCC 31586), in a suitable nutrient media.Type: GrantFiled: November 17, 1980Date of Patent: January 19, 1982Assignee: Merck & Co., Inc.Inventors: Sebastian Hernandez, Sheldon B. Zimmerman, Vincent P. Gullo, Ray S. Dewey
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Patent number: 4285963Abstract: There are disclosed certain new derivatives of C-076 compounds which have been isolated from the fermentation broth that produced the original C-076 compounds. The compounds retain the C-076 16-membered cyclic backbone, however, the groups attached thereto are considerably modified from the original C-076 compounds. The new compounds have been found to retain the biological activity of the parent C-076 compounds. The compounds are thus potent antiparasitic agents and compositions and methods for such uses are also disclosed.Type: GrantFiled: August 7, 1980Date of Patent: August 25, 1981Assignee: Merck & Co., Inc.Inventors: Byron H. Arison, Robert T. Goegelman, Vincent P. Gullo
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Patent number: 4198338Abstract: Fermentation broths or impure solutions containing thienamycin, a substance having antibiotic activity against gram-negative and gram-positive microorganisms, are purified using a sequence of ion exchange resins, starting with an anion exchange resin of the polystyrene-trimethylammonium type in the HCO.sub.3 -cycle, and ending with absorption on and elution from a polymeric cross-linked polystyrene-type resin adsorbent. Variations in the intermediate steps, e.g. different resins and eluates are possible and are illustrated within.Type: GrantFiled: March 13, 1978Date of Patent: April 15, 1980Assignee: Merck & Co., Inc.Inventors: Laszlo R. Treiber, Vincent P. Gullo