Patents by Inventor Vincent P. Stanton, Jr.

Vincent P. Stanton, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190070132
    Abstract: The invention features compositions, methods, and kits containing (i) one or more cysteamine precursor compounds convertible to cysteamine in vivo, and (ii) optionally agents to enhance that conversion, formulated to produce a spectrum of pharmacokinetic profiles of cysteamine that can be tailored to individual patients and diseases. The invention also features varying modes of administration of the therapeutic substances in the treatment of cystinosis and other cysteamine sensitive disorders. In particular, formulations combining active ingredient(s) with pharmaceutical excipients that permit sustained cysteamine plasma concentrations are featured.
    Type: Application
    Filed: March 17, 2017
    Publication date: March 7, 2019
    Inventors: Vincent P. STANTON, Jr., Patrice P. RIOUX
  • Publication number: 20150056612
    Abstract: Described are methods for identifying targets in RNA molecules based on differences in RNA secondary structure related to sequence variances between different allelic forms. Also described are methods for identifying or developing small molecules which can be used to modulate a target RNA by creation of protein-small-molecule-RNA complexes, as well as compositions which include such small molecules and methods of using those small molecules and compositions.
    Type: Application
    Filed: March 4, 2013
    Publication date: February 26, 2015
    Inventors: LING X. SHEN, GREGORY L. VERDINE, JAMES P. BASILION, VINCENT P STANTON, JR.
  • Publication number: 20140193809
    Abstract: Methods for determining genotypes and haplotypes of genes are described. Also described are single nucleotide polymorphisms and haplotypes in the ApoE gene and methods of using that information.
    Type: Application
    Filed: November 6, 2013
    Publication date: July 10, 2014
    Inventors: Jeffrey Olson, Vincent P. Stanton, JR.
  • Publication number: 20130164744
    Abstract: Methods for determining genotypes and haplotypes of genes are described. Also described are single nucleotide polymorphisms and haplotypes in the ApoE gene and methods of using that information.
    Type: Application
    Filed: June 25, 2012
    Publication date: June 27, 2013
    Inventors: Jeffrey Olson, Vincent P. Stanton, JR.
  • Patent number: 8389484
    Abstract: Described are methods for identifying targets in RNA molecules based on differences in RNA secondary structure related to sequence variances between different allelic forms. Also described are methods for identifying or developing small molecules which can be used to modulate a target RNA by creation of protein-small-molecule-RNA complexes, as well as compositions which include such small molecules and methods of using those small molecules and compositions.
    Type: Grant
    Filed: November 29, 2004
    Date of Patent: March 5, 2013
    Inventors: Ling X. Shen, Gregory L. Verdine, James P. Basilion, Vincent P. Stanton, Jr.
  • Publication number: 20130040293
    Abstract: Methods for determining genotypes and haplotypes of genes are described. Also described are single nucleotide polymorphisms and haplotypes in the ApoE gene and methods of using that information.
    Type: Application
    Filed: March 5, 2012
    Publication date: February 14, 2013
    Inventors: JEFFREY OLSON, MARTIN ZILLMANN, VINCENT P. STANTON, JR.
  • Publication number: 20120135402
    Abstract: The present disclosure describes the use of genetic variance information for folate transport or metabolism genes or pyrimidine transport or metabolism genes in the selection of effective methods of treatment of a disease or condition. The variance information is indicative of the expected response of a patient to a method of treatment. Methods of determining relevant variance information and additional methods of using such variance information are also described.
    Type: Application
    Filed: May 20, 2011
    Publication date: May 31, 2012
    Inventor: Vincent P. Stanton, Jr.
  • Patent number: 8129120
    Abstract: Methods for determining genotypes and haplotypes of genes are described. Also described are single nucleotide polymorphisms and haplotypes in the ApoE gene and methods of using that information.
    Type: Grant
    Filed: February 28, 2007
    Date of Patent: March 6, 2012
    Assignee: Sequenom, Inc.
    Inventors: Jeffrey Olson, Martin Zillmann, Vincent P. Stanton, Jr.
  • Publication number: 20110287419
    Abstract: Methods for determining genotypes and haplotypes of genes are described. Also described are single nucleotide polymorphisms and haplotypes in the ApoE gene and methods of using that information.
    Type: Application
    Filed: March 21, 2011
    Publication date: November 24, 2011
    Inventors: Jeffrey Olson, Vincent P. Stanton, JR.
  • Publication number: 20100291568
    Abstract: Methods for determining genotypes and haplotypes of genes are described. Also described are single nucleotide polymorphisms and haplotypes in the ApoE gene and methods of using that information.
    Type: Application
    Filed: February 9, 2010
    Publication date: November 18, 2010
    Inventors: Jeffrey Olson, Vincent P. Stanton, JR.
  • Publication number: 20100099087
    Abstract: The present disclosure describes the use of genetic variance information for folate transport or metabolism genes or pyrimidine transport or metabolism genes in the selection of effective methods of treatment of a disease or condition. The variance information is indicative of the expected response of a patient to a method of treatment. Methods of determining relevant variance information and additional methods of using such variance information are also described.
    Type: Application
    Filed: February 20, 2009
    Publication date: April 22, 2010
    Inventor: Vincent P. Stanton, Jr.
  • Patent number: 7659054
    Abstract: The presently claimed invention concerns a method for biasing the amplification of the DNA molecules in a sample such that a nucleic acid molecule having a specific nucleotide at a selected position (e.g., a polymorphic site) is preferentially amplified relative to an otherwise identical nucleic acid molecule not having the specific nucleotide at the selected position. The method entails amplification of target nucleic acid molecules using a pair of primers one of which causes the incorporation into the amplification product of a sequence that interferes with amplification of nucleic acid molecules not having the specific nucleotide at the selected position. The method is useful for preferentially amplifying at least a portion of one allele of a gene relative to another, different allele of the gene in a sample containing both alleles of the gene.
    Type: Grant
    Filed: October 25, 2000
    Date of Patent: February 9, 2010
    Assignee: Nuvelo, Inc.
    Inventors: Jeffrey Olson, Vincent P. Stanton, Jr.
  • Patent number: 7435541
    Abstract: Methods for determining genotypes and haplotypes of genes are described. Also described are single nucleotide polymorphisms and haplotypes in the ApoE gene and methods of using that information.
    Type: Grant
    Filed: April 4, 2002
    Date of Patent: October 14, 2008
    Assignee: Sequenom, Inc.
    Inventors: Jeffrey Olson, Martin Zillmann, Vincent P. Stanton, Jr.
  • Patent number: 7115372
    Abstract: Described are methods for identifying targets in RNA molecules based on differences in RNA secondary structure related to sequence variances between different allelic forms. Also described are methods for identifying or developing small molecules which can be used to modulate a target RNA by creation of protein-small-molecule-RNA complexes, as well as compositions which include such small molecules and methods of using those small molecules and compositions.
    Type: Grant
    Filed: September 26, 2002
    Date of Patent: October 3, 2006
    Assignee: Variagenics, Inc.
    Inventors: Ling X. Shen, Gregory L. Verdine, James P. Basilion, Vincent P. Stanton, Jr.
  • Patent number: 6994998
    Abstract: The present invention relates to methods for the detection of polymorphisms by substituting a base-modified nucleotide for a natural nucleotide in a polynucleotide. The base-modified nucleotide renders the polynucleotide more susceptible to cleavage at the sites of its incorporation than site consisting of natural nucleotides. The fragments obtained are then analyzed to determine the presence or absence of a polymorphism.
    Type: Grant
    Filed: January 8, 2002
    Date of Patent: February 7, 2006
    Assignee: Sequenom, Inc.
    Inventors: Vincent P. Stanton, Jr., Jia Liu Wolfe, Tomohiko Kawate, Charles Allerson, Gregory L. Verdine
  • Patent number: 6855500
    Abstract: The present invention relates to a method for genotyping a diploid organism to detect single nucleotide polymorphisms (SNPs) using modified nucleotides or nucleotide residues substituted with fluorescent groups.
    Type: Grant
    Filed: March 26, 2002
    Date of Patent: February 15, 2005
    Assignee: Sequenom, Inc.
    Inventors: Jia Liu Wolfe, Tomohiko Kawate, Charles R. Allerson, Vincent P. Stanton, Jr.
  • Patent number: 6777188
    Abstract: The present invention relates to a method for genotyping a diploid organism by cleaving segments of two alleles such that 7-20 nucleotide fragments that contain a suspected polymorphic locus are produced and comparing the masses of those fragments.
    Type: Grant
    Filed: March 26, 2002
    Date of Patent: August 17, 2004
    Assignee: Variagenics, Inc.
    Inventors: Vincent P. Stanton, Jr., Jeffrey Olson, Jia Liu Wolfe, Martin Zillmann
  • Patent number: 6759200
    Abstract: The present disclosure describes the use of genetic variance information for folate transport or metabolism genes or pyrimidine transport or metabolism genes in the selection of effective methods of treatment of a disease or condition. The variance information is indicative of the expected response of a patient to a method of treatment. Methods of determining relevant variance information and additional methods of using such variance information are also described.
    Type: Grant
    Filed: September 24, 2001
    Date of Patent: July 6, 2004
    Assignee: Nuvelo, Inc.
    Inventor: Vincent P. Stanton, Jr.
  • Patent number: 6686148
    Abstract: Methods are described for identifying an RNA target for an allele-specific RNA inhibitor by identifying a sequence variance in an RNA encoded by a gene of interest, and determining whether the secondary structure of the RNA comprising the variance differs from that of an otherwise identical RNA not comprising the variance.
    Type: Grant
    Filed: February 29, 2000
    Date of Patent: February 3, 2004
    Assignee: Nuvelo, Inc.
    Inventors: Ling X. Shen, Gregory L. Verdine, James P. Basilion, Vincent P. Stanton, Jr.
  • Patent number: 6673551
    Abstract: Disclosed are methods and reagents for detecting nucleotide mismatches (for example, due to sequence variances) in a nucleic acid sample involving the use of a nucleic acid probe derived from a hemizygous cell. Methods for determining the haplotype of a nucleic acid sample are also disclosed. Also disclosed are methods for producing the probe and kits containing the probe.
    Type: Grant
    Filed: January 7, 2002
    Date of Patent: January 6, 2004
    Assignee: Variagenics, Inc.
    Inventor: Vincent P. Stanton, Jr.