Abstract: An in vitro method for predicting a likelihood of an individual having a cancer to efficiently respond to an anti-cancer treatment, said method including the steps: of a) measuring the level of nuclear expression of TRF2 in a biopsy obtained from said individual, b) comparing the level obtained in step a) to a reference value, and c) determining the predicted likelihood of said individual to efficiently respond to said anti-cancer treatment from the comparison performed in step b).