Patents by Inventor Vincent R. Zurawski

Vincent R. Zurawski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunoassay utilizing monoclonal high affinity IgM antibodies
    Patent number: 4879219
    Abstract: Hybridomally produced monoclonal IgM antibodies having high affinity are useful for the immunoassay and purification of viral antigens.
    Type: Grant
    Filed: September 19, 1980
    Date of Patent: November 7, 1989
    Assignee: General Hospital Corporation
    Inventors: Jack R. Wands, Vincent R. Zurawski, Jr., Schoemaker, Hubert J. P.
  • Immunoassay for multi-determinant antigens using high-affinity
    Patent number: 4837167
    Abstract: A simultaneous sandwich immunoassay employing high-affinity monoclonal antibodies is disclosed. This simultaneous sandwich assembly has surprising sensitivity compared to forward and reverse sandwich assays for the detection of multi-determinant antigens such as hepatitis B surface antigen.
    Type: Grant
    Filed: April 24, 1984
    Date of Patent: June 6, 1989
    Assignees: Centocor, Inc., The General Hospital Corporation, Centocor, Inc.
    Inventors: Hubert J. P. Schoemaker, Jack R. Wands, Barbara L. Westrick, Vincent R. Zurawski, Jr.
  • Process for producing antibodies to hepatitis virus and cell lines therefor
    Patent number: 4491632
    Abstract: Cell lines for producing monoclonal antibodies to hepatitis virus are established by immunizing animal lymphocytes with hepatitis antigen to form antibody producing cells which then are fused with myeloma cells. The resultant somatic cell hybrids can be cloned. These clones produce monoclonal antibodies to individual antigenic determinates unique to hepatitis virus.
    Type: Grant
    Filed: July 26, 1983
    Date of Patent: January 1, 1985
    Assignee: The Massachusetts General Hospital
    Inventors: Jack R. Wands, Vincent R. Zurawski, Jr.
  • Process for producing antibodies to hepatitis virus and cell lines therefor
    Patent number: 4271145
    Abstract: Cell lines for producing monoclonal antibodies to hepatitis virus are established by immunizing animal lymphocytes with hepatitis antigen to form antibody producing cells which then are fused with myeloma cells. The resultant somatic cell hybrids can be cloned. These clones produce monoclonal antibodies to individual antigenic determinates unique to hepatitis virus.
    Type: Grant
    Filed: October 22, 1979
    Date of Patent: June 2, 1981
    Assignee: The Massachusetts General Hospital
    Inventors: Jack R. Wands, Vincent R. Zurawski, Jr.
  • Process for rosetting human B lymphocytes with Rhesus monkey erythrocyte
    Patent number: 4192917
    Abstract: Human peripheral blood lymphocytes are stimulated with either a polyclonal activator or an antigen which gives rise to immunologically activated B lymphocytes. These activated B lymphocytes are separated from non-activated B lymphocytes by relying on the fact that activated B lymphocytes possess a surface marker; the ability to rosette Rhesus monkey lymphocytes (RhMRBC), not found on their non-activated counterparts. Separation is achieved by rosetting with RhMRBC and subsequent density centrifugation of cells.
    Type: Grant
    Filed: April 5, 1979
    Date of Patent: March 11, 1980
    Assignee: Massachusetts General Hospital
    Inventor: Vincent R. Zurawski, Jr.