Abstract: A system and method are disclosed including a computer and a processor and memory. The computer receives option constraint limiting values of a second option parameter based on a value for a first option parameter, wherein the first option parameter and the second option parameter comprise mix rates for options for a configuration. The computer further generates an interactive element for setting values of the first option parameter and an interactive element for setting the value for the second option parameter and displays the one or more interactive elements. The computer still further, in response to a value being set for the first option parameter, calculates limits for the values of the second option parameters and prevents the interactive element for setting the value for the second option parameter to be set to values outside of the calculated limits.

Abstract: A system and method are disclosed including a computer and a processor and memory. The computer receives option constraint limiting values of a second option parameter based on a value for a first option parameter, wherein the first option parameter and the second option parameter comprise mix rates for options for a configuration. The computer further generates an interactive element for setting values of the first option parameter and an interactive element for setting the value for the second option parameter and displays the one or more interactive elements. The computer still further, in response to a value being set for the first option parameter, calculates limits for the values of the second option parameters and prevents the interactive element for setting the value for the second option parameter to be set to values outside of the calculated limits.

Abstract: A forming tool with forced thermal fluid-based spatio-temporal temperature control of a surface of the tool has a subsurface manifold underlying at least a part of a forming surface of the tool and a number P of at least 6 ports, each port fluid coupled respectively to the manifold via respective channels, where the ports exit the tool at disparate points, with each pair of ports in fluid communication via the manifold. This structure allows manifold path diversity for varying thermal fluid supply and drainage. The manifold may be reinforced.

Abstract: A system and method are disclosed including a production planner that receives a sales forecast for configurations of an automobile. The production planner also receives constraints associated with an automobile supply chain. The production planner further models configurations and constraints as a production planning problem, solves a production plan for automobiles, and displays an automobile production solution of the production planning problem.

Abstract: A system and method are disclosed including a production planner that receives a sales forecast for configurations of an automobile. The demand planner also receives constraints associated with an automobile supply chain. The demand planner further models configurations and constraints as a mixed integer linear programming problem, determines a production plan for automobiles, and sends instructions to cause automated machinery to retrieve an amount of automobiles equal to a forecasted production level minus a current inventory level and to move the amount of the automobile to an inventory location of the automobile.

Abstract: An active downhole antenna located in a borehole receives electromagnetic (EM) telemetry transmissions from sources in adjacent boreholes. The antenna comprises a processor operable do decode and measure signal to noise ratio of received transmissions. Data received at the active antenna is transmitted to surface using a high-speed data communication network. The active antenna may handle data communications from multiple downhole EM telemetry transmitters.

Abstract: A system and method are disclosed including a production planner that receives a sales forecast for configurations of an automobile. The production planner also receives constraints associated with an automobile supply chain. The production planner further models configurations and constraints as a production planning problem, solves a production plan for automobiles, and displays an automobile production solution of the production planning problem.

Abstract: A system and method are disclosed including a production planner that receives a sales forecast for configurations of an automobile. The production planner also receives constraints associated with an automobile supply chain. The production planner further models configurations and constraints as a production planning problem, solves a production plan for automobiles, and displays an automobile production solution of the production planning problem.

Abstract: A wireless communications system for a downhole drilling operation comprises a drill string, surface communications equipment, and a downhole telemetry tool. The surface communications equipment comprises a surface EM communications module with an EM downlink transmitter configured to transmit through at least a portion of the drill string an EM downlink transmission at a frequency between 0.5 Hz and 180 kHz. The downhole telemetry tool is mountable to a drill string and has a downhole electromagnetic (EM) communications unit with an EM downlink receiver configured to receive the EM downlink transmission. The downhole EM communications unit can further comprise an EM uplink transmitter configured to transmit an EM uplink transmission at a frequency GO between 0.5 Hz and 180 kHz, in which case the surface EM communications module further comprises an EM uplink receiver configured to receive the EM uplink transmission.

Abstract: A system and method are disclosed including a production planner that receives a sales forecast for configurations of an automobile. The demand planner also receives constraints associated with an automobile supply chain. The demand planner further models configurations and constraints as a mixed integer linear programming problem, determines a production plan for automobiles, and sends instructions to cause automated machinery to retrieve an amount of automobiles equal to a forecasted production level minus a current inventory level and to move the amount of the automobile to an inventory location of the automobile.

Abstract: An active downhole antenna located in a borehole receives electromagnetic (EM) telemetry transmissions from sources in adjacent boreholes. The antenna comprises a processor operable do decode and measure signal to noise ratio of received transmissions. Data received at the active antenna is transmitted to surface using a high-speed data communication network. The active antenna may handle data communications from multiple downhole EM telemetry transmitters.

Abstract: A system and method are disclosed including a production planner that receives a sales forecast for configurations of an automobile. The demand planner also receives constraints associated with an automobile supply chain. The demand planner further models configurations and constraints as a mixed integer linear programming problem, determines a production plan for automobiles, and sends instructions to cause automated machinery to retrieve an amount of automobiles equal to a forecasted production level minus a current inventory level and to move the amount of the automobile to an inventory location of the automobile.

Abstract: A compute device can receive a signal associated with a quantity of real-world activity (e.g., exercise) performed by a user. The compute device can define a quantity of virtual activity based, at least in part, on the quantity of real-world activity. The quantity of virtual activity can be different from the quantity of real-world activity. The compute device can send an indication of progress in a virtual world to an output device, for example, such that the user's progress is displayed.

Abstract: A compute device can receive a signal associated with a quantity of real-world activity (e.g., exercise) performed by a user. The compute device can define a quantity of virtual activity based, at least in part, on the quantity of real-world activity. The quantity of virtual activity can be different from the quantity of real-world activity. The compute device can send an indication of progress in a virtual world to an output device, for example, such that the user's progress is displayed.

Abstract: A compute device can receive a signal associated with a quantity of real-world activity (e.g., exercise) performed by a user. The compute device can define a quantity of virtual activity based, at least in part, on the quantity of real-world activity. The quantity of virtual activity can be different from the quantity of real-world activity. The compute device can send an indication of progress in a virtual world to an output device, for example, such that the user's progress is displayed.

Abstract: A compute device can receive a signal associated with a quantity of real-world activity (e.g., exercise) performed by a user. The compute device can define a quantity of virtual activity based, at least in part, on the quantity of real-world activity. The quantity of virtual activity can be different from the quantity of real-world activity. The compute device can send an indication of progress in a virtual world to an output device, for example, such that the user's progress is displayed.

Abstract: A compute device can receive a signal associated with a quantity of real-world activity (e.g., exercise) performed by a user. The compute device can define a quantity of virtual activity based, at least in part, on the quantity of real-world activity. The quantity of virtual activity can be different from the quantity of real-world activity. The compute device can send an indication of progress in a virtual world to an output device, for example, such that the user's progress is displayed.

Abstract: Mutations in the atypical protein kinase C-interacting protein p62/sequestosome 1 (p62/SQSTM1) causing Paget disease of bone are described. Methods of detecting and treating Paget disease of bone are also disclosed.

Abstract: Mutations in the atypical protein kinase C-interacting protein p62/sequestosome 1 (p62/SQSTM1) causing Paget disease of bone are described. Methods of detecting and treating Paget disease of bone are also disclosed.

Abstract: Promoter sequences of the optineurin gene can be used to diagnose, prognose, and treat glaucoma and related disorders. Methods, kits, and nucleic acids capable of detecting or containing polymorphisms located within the promoter region of the optineurin gene are also provided. The promoter sequences can also be used to generate cells, vectors, and nucleic acids useful in a variety of diagnostic and prognostic methods and kits as well as therapeutic compounds, compositions and methods.