Patents by Inventor Vincent Reboul

Vincent Reboul has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL PATHWAY FOR THE SYNTHESIS OF DIAZIRINES, THAT MAY OR MAY NOT BE ENRICHED IN NITROGEN-15
    Publication number: 20220098155
    Abstract: The present invention concerns a novel method for synthesising diazirines, that may or may not be enriched in nitro-gen-15, from amino acids or imines, via a one-pot synthesis method, comprising the reaction of the starting amino acid or imine with ammonia, which may or may not be enriched in nitrogen-15, and a hypervalent iodine oxidant. The present invention also relates to a method for synthesising ammonia enriched in nitrogen-15. The invention also concerns certain diazirines of formula (I) likely to be obtained by the claimed synthesis method, and also refers to the 15N2-diazirines of formula (I?). The claimed diazirines can be used in photoaffinity labelling. The 15N2-diazirines can also be used in hyperpolarisation, in particular in the medical imaging field.
    Type: Application
    Filed: November 14, 2019
    Publication date: March 31, 2022
    Inventors: Vincent REBOUL, Xavier FRANCK, Thomas GLACHET, Hamid MARZAG
  • Taxane synthesis method and intermediates
    Patent number: 6630609
    Abstract: A process for the preparation of a composition having the formula: in which a compound having the formula: is treated with a base and a silylating agent.
    Type: Grant
    Filed: July 16, 2002
    Date of Patent: October 7, 2003
    Assignee: Florida State University
    Inventors: Robert A. Holton, Phong Vu, Tawfik Gharbaoui, Vincent Reboul
  • Taxane synthesis method and intermediates
    Publication number: 20030097024
    Abstract: A process for the preparation of a composition having the formula: 1
    Type: Application
    Filed: July 16, 2002
    Publication date: May 22, 2003
    Applicant: Florida State University
    Inventors: Robert A. Holton, Phong Vu, Tawfik Gharbaoui, Vincent Reboul
  • Method for the synthesis of taxanes
    Patent number: 6441253
    Abstract: A process for the preparation of a compound having the formula: the process comprising treating a compound having the formula: with an alkyl metal species or with a Lewis acid in the presence of a tertiary amine base, wherein P2 is hydrogen or a hydroxyl protecting group.
    Type: Grant
    Filed: July 17, 2000
    Date of Patent: August 27, 2002
    Assignee: Florida State University
    Inventors: Robert A. Holton, Phong Vu, Tawfik Gharbaoui, Vincent Reboul
  • Method for the synthesis of a taxane intermediate
    Patent number: 6111144
    Abstract: A process for the preparation of a compound having the formula: ##STR1## in which a compound having the formula: ##STR2## is treated with a base and a silylating agent.
    Type: Grant
    Filed: August 20, 1998
    Date of Patent: August 29, 2000
    Assignee: Florida State University
    Inventors: Robert A. Holton, Phong Vu, Tawfik Gharbaoui, Vincent Reboul