Abstract: This invention relates to a method of using MOF adsorbents to remove elemental impurities from feed streams comprising active pharmaceutical ingredients (API). The process involves contacting the feed stream comprising API and elemental impurities with the MOF at purification conditions to obtain a purified stream with provides an API which has a concentration of the elemental impurity below its permitted daily exposure. The process can be carried in a batch mode where the MOF and feed stream are admixed in a vessel for a given amount of time or continuously by flowing the feed stream through a column or adsorbent bed containing the MOF adsorbent.

Abstract: Functionalized polymer adsorbents for removing impurities from a feed stream comprising an active pharmaceutical ingredient (API) include particles of functionalized with at least one functional moiety capable of binding one or more contaminants, the polymer being a macroreticular polymer and the functionalized polymer adsorbents having a pore volume of at least 0.65 cm3/g. Alternatively, the adsorbent can comprise a polymer functionalized with either 2,4,6,-dimercaptotriazine-ethylenedithiol (DMT-EDT) adduct, 2,4,6,-trimercaptotriazine-ethylenedithiol (TMT-EDT) adduct, or a combination thereof, and the polymer can be either a macroreticular polymer or a swellable polymer. The adsorbents can be used in either continuous or batch processes for removing contaminants from an API-containing feed stream wherein the contaminants can include elemental impurities, particularly palladium.

Abstract: This invention relates to a method of using MOF adsorbents to remove elemental impurities from feed streams comprising active pharmaceutical ingredients (API). The process involves contacting the feed stream comprising API and elemental impurities with the MOF at purification conditions to obtain a purified stream with provides an API which has a concentration of the elemental impurity below its permitted daily exposure. The process can be carried in a batch mode where the MOF and feed stream are admixed in a vessel for a given amount of time or continuously by flowing the feed stream through a column or adsorbent bed containing the MOF adsorbent.