Patents by Inventor Vincent Tabard-Cossa
Vincent Tabard-Cossa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11198946Abstract: Nanopore arrays are fabricated by controlled breakdown in solid-state membranes integrated within polydimethylsiloxane (PDMS) microfluidic devices. This technique enables the scalable production of independently addressable nanopores. By confining the electric field within the microfluidic architecture, nanopore fabrication is precisely localized and electrical noise is significantly reduced during sensing.Type: GrantFiled: June 22, 2020Date of Patent: December 14, 2021Assignee: THE UNIVERSITY OF OTTAWAInventors: Vincent Tabard-Cossa, Michel Godin, Radin Tahvildari, Eric Beamish
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Publication number: 20200340943Abstract: Methods for determining molecular concentration using solid-state nanopores are provided. The methods include measuring a current signal and using the signal to identify first and second electrical signatures. A first set is used to determine a first rate of a target having an unknown concentration, and a second set is used to determine a second rate of a control having a known concentration. The first and second rates are each a function of a pore property factor that represents physical properties of the solid-state nanopore and operating conditions. The first rate is further a function of a first property factor that represents physical properties of the target and the unknown concentration. The second rate is further a function of a second property factor that represents physical properties of the control and the known concentration. Ratios of the first rate to the second rate are used to determine the unknown concentration.Type: ApplicationFiled: April 26, 2019Publication date: October 29, 2020Inventors: Kyle BRIGGS, Martin CHARRON, Vincent TABARD-COSSA
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Publication number: 20200325593Abstract: Nanopore arrays are fabricated by controlled breakdown in solid-state membranes integrated within polydimethylsiloxane (PDMS) microfluidic devices. This technique enables the scalable production of independently addressable nanopores. By confining the electric field within the microfluidic architecture, nanopore fabrication is precisely localized and electrical noise is significantly reduced during sensing.Type: ApplicationFiled: June 22, 2020Publication date: October 15, 2020Applicant: THE UNIVERSITY OF OTTAWAInventors: Vincent TABARD-COSSA, Michel GODIN, Radin TAHVILDARI, Eric BEAMISH
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Patent number: 10753009Abstract: A method for fabricating a nanopore at a particular location in a membrane includes controlling a dielectric strength of the membrane at a particular location on the membrane while applying one of an electric potential or an electric current to the membrane, monitoring an electrical property across the membrane while one of the electric potential or the electric current is being applied across the membrane, detecting an abrupt change in the electrical property across the membrane while one of the electric potential or the electric current is being applied across the membrane; and removing the electric potential or the electric current from the membrane in response to detecting the abrupt change in the electrical property.Type: GrantFiled: February 24, 2016Date of Patent: August 25, 2020Assignee: THE UNIVERSITY OF OTTAWAInventors: Jose Bustamante, Kyle Briggs, Vincent Tabard-Cossa
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Patent number: 10718064Abstract: Nanopore arrays are fabricated by controlled breakdown in solid-state membranes integrated within polydimethyl-siloxane (PDMS) microfluidic devices. This technique enables the scalable production of independently addressable nanopores. By confining the electric field within the microfluidic architecture, nanopore fabrication is precisely localized and electrical noise is significantly reduced during sensing.Type: GrantFiled: December 18, 2015Date of Patent: July 21, 2020Inventors: Vincent Tabard-Cossa, Michel Godin, Radin Tahvildari, Eric Beamish
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Publication number: 20200191767Abstract: To reduce unwanted variation in the speed of DNA translocating solid-state nanopores, a nanoscale pre-confinement of translocating molecules is demonstrated using an ultra-thin nanoporous silicon nitride (NPN) membrane separated from a single sensing nanopore by a nanoscale cavity. Comprehensive experimental results demonstrate that the presence of this nanofilter results in a global minimum in the coefficient of variation of passage times in the sensing pore over a range of DNA sizes which depends on the height of the cavity. Such advanced nanopore devices minimize the standard deviation of the passage time distribution independently of its diameter and stability. These results also represents the first experimental verification that the inter- and intra-molecular passage time variation depends on the conformational entropy of such molecule prior to translocation, while providing a practical strategy for controlling transport across solid-state nanopores.Type: ApplicationFiled: April 27, 2018Publication date: June 18, 2020Inventors: Vincent TABARD-COSSA, Kyle BRIGGS, Gregory MADEJSKI, James L. MCGRATH
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Patent number: 10526218Abstract: Aspects of the present disclosure are directed to the flow of analytes, particles or other materials. As consistent with one or more embodiments described herein, an apparatus includes a membrane having one or more pores in a membrane. First and second electrodes facilitate electrophoretic flow of analytes through the pore, and a third electrode controls movement of the particles in the pore by modulating the shape of an electric double layer adjacent sidewalls of pore. This modulation controls the strength of an electroosmotic field that opposes the electrophoretic flow of the analytes via the pore.Type: GrantFiled: October 1, 2013Date of Patent: January 7, 2020Assignees: The Board of Trustees of the Leland Stanford Junior University, The University of OttawaInventors: Kee-Hyun Paik, Yang Liu, Vincent Tabard-Cossa, Robert W. Dutton
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Publication number: 20180043310Abstract: A method for fabricating a nanopore at a particular location in a membrane includes controlling a dielectric strength of the membrane at a particular location on the membrane while applying one of an electric potential or an electric current to the membrane, monitoring an electrical property across the membrane while one of the electric potential or the electric current is being applied across the membrane, detecting an abrupt change in the electrical property across the membrane while one of the electric potential or the electric current is being applied across the membrane; and removing the electric potential or the electric current from the membrane in response to detecting the abrupt change in the electrical property.Type: ApplicationFiled: February 24, 2016Publication date: February 15, 2018Applicant: The University of OttawaInventors: Jose BUSTAMANTE, Kyle BRIGGS, Vincent TABARD-COSSA
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Publication number: 20170363609Abstract: Nanopore arrays are fabricated by controlled breakdown in solid-state membranes integrated within polydimethyl-siloxane (PDMS) microfluidic devices. This technique enables the scalable production of independently addressable nanopores. By confining the electric field within the microfluidic architecture, nanopore fabrication is precisely localized and electrical noise is significantly reduced during sensing.Type: ApplicationFiled: December 18, 2015Publication date: December 21, 2017Inventors: Vincent TABARD-COSSA, Michel GODIN, Radin TAHVILDARI, Eric BEAMISH
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Patent number: 9777390Abstract: A method is provided for precisely enlarging a nanopore formed in a membrane. The method includes: applying an electric potential across the nanopore, where the electric potential has a pulsed waveform oscillating between a high value and a low value; measuring current flowing though the nanopore while the electric potential is being applied to the nanopore at a low value; determining size of the nanopore based in part on the measured current; and removing the electric potential applied to the membrane when the size of the nanopore corresponds to a desired size.Type: GrantFiled: May 7, 2013Date of Patent: October 3, 2017Assignee: THE UNIVERSITY OF OTTAWAInventors: Michel Godin, Eric Beamish, Vincent Tabard-Cossa, Wing Hei Kwok
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Patent number: 9777389Abstract: A method is provided for fabricating a nanopore in a membrane. The method includes: applying an electric potential across the membrane, where value of the electric potential is selected to induce an electric field which causes a leakage current across the membrane; monitoring current flow across the membrane while the electric potential is being applied; detecting an abrupt increase in the leakage current across the membrane; and removing the electric potential across the membrane in response to detecting the abrupt increase in the leakage current.Type: GrantFiled: May 7, 2013Date of Patent: October 3, 2017Assignee: THE UNIVERSITY OF OTTAWAInventors: Wing Hei Kwok, Vincent Tabard-Cossa, Kyle Alexander Zarkel Briggs
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Publication number: 20150109008Abstract: A method is provided for precisely enlarging a nanopore formed in a membrane. The method includes: applying an electric potential across the nanopore, where the electric potential has a pulsed waveform oscillating between a high value and a low value; measuring current flowing though the nanopore while the electric potential is being applied to the nanopore at a low value; determining size of the nanopore based in part on the measured current; and removing the electric potential applied to the membrane when the size of the nanopore corresponds to a desired size.Type: ApplicationFiled: May 7, 2013Publication date: April 23, 2015Inventors: Michel Godin, Eric Beamish, Vincent Tabard-Cossa, Wing Hei Kwok
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Publication number: 20150108008Abstract: A method is provided for fabricating a nanopore in a membrane. The method includes: applying an electric potential across the membrane, where value of the electric potential is selected to induce an electric field which causes a leakage current across the membrane; monitoring current flow across the membrane while the electric potential is being applied; detecting an abrupt increase in the leakage current across the membrane; and removing the electric potential across the membrane in response to detecting the abrupt increase in the leakage current.Type: ApplicationFiled: May 7, 2013Publication date: April 23, 2015Inventors: Wing Hei Kwok, Vincent Tabard-Cossa, Kyle Alexander Zarkel Briggs
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Publication number: 20140174928Abstract: Various aspects of the present disclosure are directed toward apparatus and methods method for filtering water fluid by screening ionic minerals including sodium chloride from the water fluid. In one embodiment, the water fluid is passed into a work zone defined at least in part by oppositely-arranged first and second porous structures, each of which have a plurality of gated channels. The water fluid is processed in the work zone by applying respective electric voltages to electrically bias the first porous structure and the second porous structure. The respective electric voltages deplete sodium chloride ions in the water fluid in the work zone due to ion-flux continuity. In response to processing of the water fluid, ion-filtered water is collected from the work zone.Type: ApplicationFiled: October 1, 2013Publication date: June 26, 2014Inventors: Kee-Hyun Paik, Yang Liu, Vincent Tabard-Cossa, Robert W. Dutton
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Publication number: 20140090981Abstract: Aspects of the present disclosure are directed to the flow of analytes, particles or other materials. As consistent with one or more embodiments described herein, an apparatus includes a membrane having one or more pores in a membrane. First and second electrodes facilitate electrophoretic flow of analytes through the pore, and a third electrode controls movement of the particles in the pore by modulating the shape of an electric double layer adjacent sidewalls of pore.Type: ApplicationFiled: October 1, 2013Publication date: April 3, 2014Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Kee-Hyun Paik, Yang Liu, Vincent Tabard-Cossa, Robert W. Dutton