Patents by Inventor Vincent W. Coljee
Vincent W. Coljee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9447174Abstract: Methods for producing recombinant cell populations are disclosed. The disclosed methods may be used to produce therapeutic polyclonal proteins.Type: GrantFiled: September 26, 2013Date of Patent: September 20, 2016Assignee: Excelimmune Liquidating TrustInventors: Vincent W. Coljee, Gwendolyn M. Wilmes, Stuart Hicks, Kimberly L. Carey, Elizabeth R. Reczek
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Patent number: 9163232Abstract: The invention relates to a method for manufacturing a recombinant polyclonal protein composition, in particular a recombinant polyclonal antibody composition. The method comprises obtaining a collection of cells transfected with a library of variant nucleic acid sequences, wherein each call in the collection is transfected with and capable of expressing one member of the library, which encodes a distinct member of a polyclonal protein that binds a particular antigen and which is located at the same single site in the genome of individual cells in said collection, wherein said nucleic acid sequence is not naturally associated with said cell in the collection. The cells are cultured under suitable conditions for expression of the polyclonal protein, which is obtained from the cells or culture supernatant. The present method is suitable for manufacturing recombinant polyclonal antibodies, thereby making available a superior replacement of plasma-derived therapeutic immunoglobulin products.Type: GrantFiled: December 19, 2008Date of Patent: October 20, 2015Assignee: Symphogen A/SInventors: John S. Haurum, Finn C. Wiberg, Vincent W. Coljee, Jacqueline Sharon, Chiou-Ying Yang
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Publication number: 20140127743Abstract: Methods for producing recombinant cell populations are disclosed. The disclosed methods may be used to produce therapeutic polyclonal proteins.Type: ApplicationFiled: September 26, 2013Publication date: May 8, 2014Applicant: Excelimmune, Inc.Inventors: Vincent W. Coljee, Gwendolyn M. Wilmes, Stuart Hicks, Kimberly L. Carey, Elizabeth R. Reczek
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Publication number: 20140030269Abstract: Human antibodies that bind to one or more strains Staphylococcus aureus strains, including methicillin resistant strains, are disclosed. Also disclosed are human recombinant polyclonal antibody compositions, and therapeutic methods for using the antibodies.Type: ApplicationFiled: July 26, 2013Publication date: January 30, 2014Applicant: Excelimmune, Inc.Inventor: Vincent W. Coljee
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Patent number: 8617881Abstract: Methods for producing recombinant cell populations are disclosed. The disclosed methods may be used to produce therapeutic polyclonal proteins.Type: GrantFiled: June 13, 2012Date of Patent: December 31, 2013Assignee: Excelimmune, Inc.Inventors: Vincent W. Coljee, Gwendolyn M. Wilmes, Stuart Hicks, Kimberly L. Carey, Elizabeth R. Reczek
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Publication number: 20120302464Abstract: Methods for producing recombinant cell populations are disclosed. The disclosed methods may be used to produce therapeutic polyclonal proteins.Type: ApplicationFiled: June 13, 2012Publication date: November 29, 2012Applicant: EXCELIMMUNE, INC.Inventor: Vincent W. Coljee
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Publication number: 20090317875Abstract: The present invention provides an improved system for linking nucleic acids to one another. In particular, the present invention provides techniques for producing DNA product molecules that may be easily and directly ligated to recipient molecules. The product molecules need not be cleaved with restriction enzymes in order to undergo such ligation. In preferred embodiments of the invention, the DNA product molecules are produced through iterative DNA synthesis reactions, so that the product molecules are amplified products. The invention further provides methods for directed ligation of product molecules (i.e., for selective ligation of certain molecules within a collection of molecules), and also for methods of exon shuffling, in which multiple different product molecules are produced in a single ligation reaction. Preferred embodiments of the invention involve ligation of product molecules encoding functional protein domains, particularly domains naturally found in conserved gene families.Type: ApplicationFiled: August 25, 2009Publication date: December 24, 2009Applicant: TRUSTEES OF BOSTON UNIVERSITYInventors: KEVIN A. JARRELL, VINCENT W. COLJEE, WILLIAM DONAHUE, SVETLANA MIKHEEVA
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Patent number: 7579146Abstract: The present invention provides an improved system for linking nucleic acids to one another. In particular, the present invention provides techniques for producing DNA product molecules that may be easily and directly ligated to recipient molecules. The product molecules need not be cleaved with restriction enzymes in order to undergo such ligation. In preferred embodiments of the invention, the DNA product molecules are produced through iterative DNA synthesis reactions, so that the product molecules are amplified products. The invention further provides methods for directed ligation of product molecules (i.e., for selective ligation of certain molecules within a collection of molecules), and also for methods of exon shuffling, in which multiple different product molecules are produced in a single ligation reaction. Preferred embodiments of the invention involve ligation of product molecules encoding functional protein domains, particularly domains naturally found in conserved gene families.Type: GrantFiled: June 29, 2001Date of Patent: August 25, 2009Assignee: Trustees of Boston UniversityInventors: Kevin A. Jarrell, Vincent W. Coljee, William Donahue, Svetlana Mikheeva
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Publication number: 20090136498Abstract: The invention relates to a method for manufacturing a recombinant polyclonal protein composition, in particular a recombinant polyclonal antibody composition. The method comprises obtaining a collection of cells transfected with a library of variant nucleic acid sequences, wherein each call in the collection is transfected with and capable of expressing one member of the library, which encodes a distinct member of a polyclonal protein that binds a particular antigen and which is located at the same single site in the genome of individual cells in said collection, wherein said nucleic acid sequence is not naturally associated with said cell in the collection. The cells are cultured under suitable conditions for expression of the polyclonal protein, which is obtained from the cells or culture supernatant. The nucleic acid sequence id introduced into the cells by transfection with a library of vectors for site-specific integration.Type: ApplicationFiled: December 19, 2008Publication date: May 28, 2009Inventors: John S. Haurum, Finn C. Wiberg, Vincent W. Coljee, Jacqueline Sharon, Chiou-Ying Yang
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Patent number: 7439021Abstract: The present invention provides an improved system for linking nucleic acids to one another. In particular, the present invention provides techniques for producing DNA product molecules that may be easily and directly ligated to recipient molecules. The product molecules need not be cleaved with restriction enzymes in order to undergo such ligation. In preferred embodiments of the invention, the DNA product molecules are produced through iterative DNA synthesis reactions, so that the product molecules are amplified products. The invention further provides methods for directed ligation of product molecules (i.e., for selective ligation of certain molecules within a collection of molecules), and also for methods of exon shuffling, in which multiple different product molecules are produced in a single ligation reaction. Preferred embodiments of the invention involve ligation of product molecules encoding functional protein domains, particularly domains naturally found in conserved gene families.Type: GrantFiled: May 18, 2005Date of Patent: October 21, 2008Assignee: Trustees of Boston UniversityInventors: Kevin A. Jarrell, Vincent W. Coljee, William Donahue, Svetlana Mikheeva
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Patent number: 6358712Abstract: The present invention provides an improved system for linking nucleic acids to one another. In particular, the present invention provides techniques for producing DNA product molecules that may be easily and directly ligated to recipient molecules. The product molecules need not be cleaved with restriction enzymes in order to undergo such ligation. In preferred embodiments of the invention, the DNA product molecules are produced through iterative DNA synthesis reactions, so that the product molecules are amplified products. The invention further provides methods for directed ligation of product molecules (i.e., for selective ligation of certain molecules within a collection of molecules), and also for methods of exon shuffling, in which multiple different product molecules are produced in a single ligation reaction. Preferred embodiments of the invention involve ligation of product molecules encoding functional protein domains, particularly domains naturally found in conserved gene families.Type: GrantFiled: January 5, 1999Date of Patent: March 19, 2002Assignee: Trustee of Boston UniversityInventors: Kevin A. Jarrell, Vincent W. Coljee, William Donahue, Svetlana Mikheeva