Abstract: According to one embodiment, a method of making an abrasive article is disclosed. The method can comprise: providing a surface; disposing magnetizable abrasive particles on the surface; and varying a magnetic field relative to the magnetizable abrasive particles to impart a non-random orientation and/or alignment to the magnetizable abrasive particles relative to the surface.

Abstract: A method for locating a vehicle, including at least one vision sensor and at least one item of equipment from among an inertial navigation unit, a satellite navigation module and an odometry sensor. The method including carrying out vision-localization from image data supplied by the at least one vision sensor, to produce first location data, and applying a Bayesian filtering via a Kalman filter, taking into account the first location data, to the data derived from the at least one item of equipment and the data from a scene model, to produce second data for locating the vehicle.

Abstract: The invention discloses an antibody-drug conjugate of Formula (I): Ab-[L-Dn]x??(I) wherein: Ab comprises a broadly neutralizing anti-HIV antibody; L comprises a linker molecule covalently bonded to said broadly neutralizing anti-HIV antibody; D comprises one or more drugs comprising an HIV therapeutic compound covalently bonded to said linker molecule L, wherein said one or more broadly neutralizing anti-HIV antibodies Ab specifically bind to an HIV envelope glycoprotein and said one or more drugs D specifically bind to an HIV envelope glycoprotein; n is selected from 1-4; and x is selected from 1-12.

Abstract: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.

Abstract: An air conditioning assembly for an environmental chamber includes a suspended ceiling below a structural ceiling creating a plenum space. The suspended ceiling is configured to cover a substantially horizontal plane of the environmental chamber while leaving a first perimeter gap adjacent to a wall of the environmental chamber and a second perimeter gap adjacent to an opposing wall of the environmental chamber. A substantially vertical wall covers a vertical plane of the plenum space. At least one fan draws air from one from the environmental chamber into the plenum space through the first perimeter gap and blows air from the plenum space into the environmental chamber through the second perimeter gap. At least one air conditioning means in fluid communication with the at least one fan conditions the air flow passing through the at least one fan. The air conditioning assembly creates substantially laminar air flow.

Abstract: Methods, apparatuses, and computer readable medium including computer program products, are provided for determining the depth of water in a well. A method may include coupling a signal onto a cable connected to a submersible well pump. The method may further include monitoring the cable to determine a first time corresponding to a first reflection of the signal caused by the cable entering a water column between a water surface and the submersible pump. The method may further include monitoring the cable to determine a second time corresponding to a second reflection of the signal caused by an impedance mismatch between the cable surrounded by water and a motor in the submersible well pump. The method may further include determining a water height between the submersible pump and the water surface from the first time and the second time.

Abstract: The invention generally relates to nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to a compound represented by structural formula I: or a pharmaceutically acceptable salt thereof, wherein the values and alternative values for the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity.

Abstract: The subject of the present invention is the use, as hydrosilylation and/or dehydrogenative silylation catalyst, of a cobalt compound of formula (1): [CO(N(SiR3)2)x]y in which: —the R symbols, which are identical or different, represent a hydrogen atom or a hydrocarbon-based radical having from 1 to 12 carbon atoms, and preferably the R symbols, which are identical or different, are chosen from the group consisting of: a hydrogen atom, alkyl groups having from 1 to 8 carbon atoms and aryl groups having from 6 to 12 carbon atoms, —x=1, 2 or 3 and—y=1 or 2.

Abstract: The invention provides a lighting module (100) for use in a luminaire (200). The lighting module (100) comprises: a base (101) having a longitudinal axis (LA) and being constructed for rotatably connecting the base (101) to a socket (119) of a luminaire (200). The lighting module (100) further comprises a carrier (102) connected to the base (101) and extending from the base (101) in the direction of the longitudinal axis (LA). The lighting 5 module (100) further comprises a light unit (103) comprising a light source (104) and a heat sink (105) for dissipating thermal energy of the light source (104). The heat sink (105) extends in the direction of the longitudinal axis (LA) and is positioned at a non-zero distance D1 to the longitudinal axis (LA). The lighting module (100) further comprising a connecting construction (106) connecting the light unit (103) rotatably to the carrier (102) for rotating 10 the light unit (103) both around the carrier (102) and longitudinal axis (LA).

Abstract: Lighting systems, devices, and units that provide illumination according to a detected orientation relative to a reference plane or a reference vector. In some examples, a light bar for use on a vehicle includes first and second sets of light emitters that are selectively activated and inactive based on a detected orientation of the light bar relative to a reference plane or reference vector.

Abstract: The present application relates to helmet pads (120) comprising a ballistic protection layer (126). It also relates to a ballistic helmet (100) that comprises a helmet pad comprising a ballistic protection layer. Further, the present application also relates to a helmet pad replacement set wherein one or more of the replacement helmet pads comprises a ballistic protection layer.

Abstract: One feature pertains to a device that includes memory circuits having resource groups and access control circuitry. The access control circuitry establishes a tiered resource group access control scheme where security and access control properties of each resource group are managed by at least one of a hard governor execution environment or at least one soft governor execution environment. The access control circuitry also enforces access permissions of each resource group set by at least one of the hard governor execution environment or the at least one soft governor execution environment of each resource group.

Abstract: An artificial agent based cognitive operating room system and a method thereof providing automated assistance for a surgical procedure are disclosed. Data related to the surgical procedure from multiple data sources is fused based on a current context. The data includes medical images of a patient acquired using one or more medical imaging modalities. Real-time quantification of patient measurements based on the data from the multiple data sources is performed based on the current context. Short-term predictions in the surgical procedure are forecasted based on the current context, the fused data, and the real-time quantification of the patient measurements. Suggestions for next steps in the surgical procedure and relevant information in the fused data are determined based on the current context and the short-term predictions. The suggestions for the next steps and the relevant information in the fused data are presented to an operator.

Abstract: Presented herein, in certain embodiments, are compositions comprising monoclonal binding agents that specifically bind to the extracellular domain of cMET and uses thereof.

Abstract: Method and apparatus are disclosed for responding to HVAC-induced vehicle microphone buffeting. An example disclosed vehicle includes a microphone, a speaker, and a buffeting detector. The example microphone is electrically coupled to an input of a voice-activated system. The example speaker is located on a front driver side of the vehicle. The example buffeting detector, when a button is activated, determines a buffeting factor of a signal captured by the microphone. Additionally, the example buffeting detector, in response to the buffeting factor satisfying a threshold, activates a relay to electrically couple the speaker to the input of the voice-activated system.

Abstract: The present disclosure provides a variant tyrosine hydroxylase that provides for increased production of L-DOPA in a host cell that expresses the tyrosine hydroxylase. The present disclosure provides nucleic acids encoding the variant tyrosine hydroxylase, and host cells genetically modified with the nucleic acids. The present disclosure provides methods of making L-DOPA in a host cell. The present disclosure provides methods of making a benzylisoquinoline alkaloid (BIA), or a BIA precursor. The present disclosure provides methods of detecting L-DOPA level in a cell. The present disclosure provides methods of identifying tyrosine hydroxylase variants that provide for increased L-DOPA production; and methods of identifying gene products that provide for increased tyrosine production.

Abstract: A timepiece or piece of jewellery made of a nickel free and cobalt free gold alloy, the composition of which includes by weight between 75% and 77.5% gold, between 1.2 and 1.6% palladium, and between 20.1 and 23.8% copper.

Abstract: A method, and corresponding system (300), for monitoring patients based on activity state and posture. Activity state and/or posture of a patient are measured. Further, one or more vital signs of the patient are measured according to a schedule. Based on the measured activity state and/or posture of the patient and the measured one or more vital signs, the schedule is adjusted and/or patient deterioration is monitored for.

Abstract: Methods for generating data models using a generative adversarial network can begin by receiving a data model generation request by a model optimizer from an interface. The model optimizer can provision computing resources with a data model. As a further step, a synthetic dataset for training the data model can be generated using a generative network of a generative adversarial network, the generative network trained to generate output data differing at least a predetermined amount from a reference dataset according to a similarity metric. The computing resources can train the data model using the synthetic dataset. The model optimizer can evaluate performance criteria of the data model and, based on the evaluation of the performance criteria of the data model, store the data model and metadata of the data model in a model storage. The data model can then be used to process production data.