Patents by Inventor Vincenzo Calvanese

Vincenzo Calvanese has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Identification of factor that promotes human HSC self-renewal
    Patent number: 11845959
    Abstract: Transient MLLT3 overexpression in culture may be used to expand human HSCs in vitro, and thereby improve the efficiency and safety of HSC transplantation.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: December 19, 2023
    Assignee: The Regents of the University of California
    Inventors: Hanna Mikkola, Vincenzo Calvanese, Andrew T. Nguyen
  • IDENTIFICATION OF FACTOR THAT PROMOTES HUMAN HSC SELF-RENEWAL
    Publication number: 20190270967
    Abstract: Transient MLLT3 overexpression in culture may be used to expand human HSCs in vitro, and thereby improve the efficiency and safety of HSC transplantation.
    Type: Application
    Filed: June 16, 2017
    Publication date: September 5, 2019
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Hanna MIKKOLA, Vincenzo CALVANESE, Andrew T. NGUYEN
  • Dual-color HIV reporter system for the detection of latently-infected cells
    Patent number: 10106818
    Abstract: The present disclosure provides for recombinant nucleic acids, and cells and virions comprising the recombinant nucleic acids, that can be used to identify, isolate, and/or purify cells latently infected with immunodeficiency virus. A subject recombinant nucleic acid includes (a) a first nucleotide sequence encoding a first reporter polypeptide that produces a first detectable signal, where the first nucleotide sequence is operably linked to an immunodeficiency virus promoter and is translated as an early gene; and (b) a second nucleotide sequence encoding a second reporter polypeptide that produces a second detectable signal that is distinguishable from the first detectable signal, where the second nucleotide sequence is operably linked to a non-immunodeficiency virus promoter. In some aspects, the first and second nucleotide sequences are both positioned between a shared 5? long terminal repeat (LTR) and a shared 3? LTR. Also provided are related methods.
    Type: Grant
    Filed: August 14, 2014
    Date of Patent: October 23, 2018
    Assignee: The J. David Gladstone Institutes
    Inventors: Eric M. Verdin, Vincenzo Calvanese
  • COMPOSITIONS AND METHODS FOR IDENTIFYING LATENTLY INFECTED CELLS
    Publication number: 20160186210
    Abstract: The present disclosure provides for recombinant nucleic acids, and cells and virions comprising the recombinant nucleic acids, that can be used to identify, isolate, and/or purify cells latently infected with immunodeficiency virus. A subject recombinant nucleic acid includes (a) a first nucleotide sequence encoding a first reporter polypeptide that produces a first detectable signal, where the first nucleotide sequence is operably linked to an immunodeficiency virus promoter and is translated as an early gene; and (b) a second nucleotide sequence encoding a second reporter polypeptide that produces a second detectable signal that is distinguishable from the first detectable signal, where the second nucleotide sequence is operably linked to a non-immunodeficiency virus promoter. In some aspects, the first and second nucleotide sequences are both positioned between a shared 5? long terminal repeat (LTR) and a shared 3? LTR. Also provided are related methods.
    Type: Application
    Filed: August 14, 2014
    Publication date: June 30, 2016
    Inventors: Eric M. Verdin, Vincenzo Calvanese