Patents by Inventor Vincenzo Di Bartolo

Vincenzo Di Bartolo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LENTIVIRAL-BASED VECTOR AND ITS USE IN DIRECTED EVOLUTION OF GENOMIC REGIONS, GENES AND POLYNUCLEOTIDES
    Publication number: 20170073672
    Abstract: Replication-defective lentiviral vectors are described. Using this vector, methods of directing evolution of a target polynucleotide of interest for obtaining variants of the target polynucleotide, methods to generate genetic variability by preparing a cell library, and methods to isolate and/or screen variants of a polynucleotide or variants of a protein able to impact the phenotype of a cell or to confer a desired phenotype to target cells and to identify theses polynucleotide variants or protein variants responsible for this phenotype are described.
    Type: Application
    Filed: November 3, 2016
    Publication date: March 16, 2017
    Inventors: Matteo NEGRONI, Sarah GALLOIS-MONTBRUN, Paola ROSSOLILLO, Vincenzo DI BARTOLO, Gilles UZE, Etienne SIMON-LORIERE, Roland MARQUET, Valerie VIVET-BOUDOU
  • Lentiviral-based vector and its use in directed evolution of genomic regions, genes and polynucleotides
    Patent number: 9518271
    Abstract: A method of directing evolution of a target polynucleotide of interest for obtaining variants of this target polynucleotide, a method to generate genetic variability by preparing a cell library, and a method to isolate or to screen variants of a polynucleotide or variants of a protein able to impact the phenotype of a cell or to confer a desired phenotype to target cells, and to identify theses polynucleotide variants or protein variants responsible for this phenotype are described.
    Type: Grant
    Filed: November 10, 2010
    Date of Patent: December 13, 2016
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
    Inventors: Matteo Negroni, Sarah Gallois-Montbrun, Paola Rossolillo, Vincenzo Di Bartolo, Gilles Uze, Etienne Simon-Loriere, Roland Marquet, Valérie Vivet-Boudou
  • LENTIVIRAL-BASED VECTOR AND ITS USE IN DIRECTED EVOLUTION OF GENOMIC REGIONS, GENES AND POLYNUCLEOTIDES
    Publication number: 20120264616
    Abstract: The present invention concerns a method of directing evolution of a target polynucleotide of interest for obtaining variants of this target polynucleotide, as well as a method to generate genetic variability by preparing a cell library. This invention also relates to a method to isolate or to screen variants of a polynucleotide or variants of a protein able to impact the phenotype of a cell or to confer a desired phenotype to target cells, and to identify theses polynucleotide variants or protein variants responsible for this phenotype.
    Type: Application
    Filed: November 10, 2010
    Publication date: October 18, 2012
    Applicants: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Matteo Negroni, Sarah Gallois-Montbrun, Paola Rossolillo, Vincenzo Di Bartolo, Gilles Uze, Etienne Simon-Loriere, Roland Marquet, Valérie Vivet-Boudou