Patents by Inventor Vincenzo Manuel MARZULLO

Vincenzo Manuel MARZULLO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR THE QUANTIFICATION OF THE ACTIVATION STATE OF G-PROTEIN-COUPLED RECEPTORS IN A HUMAN BIOLOGICAL SAMPLE
    Publication number: 20240264169
    Abstract: A method for measurement of an activation state of G-protein-coupled receptors comprises: supplying a human biological sample; preparing a fluorescent donor probe comprising an anti-GPCR Fab fragment or antibody and a fluorophore group linked via amide bond to an amino group of the N-terminal amino acid of the light chain and/or of the N-terminal amino acid of the heavy chain of the Fab fragment or antibody; preparing a fluorescent acceptor probe comprising an anti-G-protein and/or anti-arrestin Fab fragment or antibody and a fluorophore group linked via amide bond to an amino group of the N-terminal amino acid of the light chain and/or of the N-terminal amino acid of the heavy chain of the Fab fragment or antibody; setting the human biological sample in contact with the fluorescent acceptor probe and with the fluorescent donor probe; sensing the activation state of the GCPR receptors by means of fluorescence microscopy techniques.
    Type: Application
    Filed: May 25, 2022
    Publication date: August 8, 2024
    Applicant: ALDA S.R.L.
    Inventors: Alberto LUINI, Matteo LO MONTE, Vincenzo Manuel MARZULLO, Federica LICCARDO
  • Reagents for optical microscopy
    Patent number: 11860099
    Abstract: An antibody or Fab fragment, wherein at least one amino group of the N-terminal amino acid of the light chain and/or of the N-terminal amino acid of the heavy chain is bound by an amidic bond to a molecule comprising a fluorophore group A, wherein said bond constitutes at least 70% of the total binding of said molecule to said antibody or Fab.
    Type: Grant
    Filed: June 26, 2018
    Date of Patent: January 2, 2024
    Assignee: Alda S.r.l.
    Inventors: Alberto Luini, Vincenzo Manuel Marzullo, Giuseppe Palumbo, Federica Liccardo
  • NEW REAGENTS FOR OPTICAL MICROSCOPY
    Publication number: 20200141869
    Abstract: An antibody or Fab fragment, wherein at least one amino group of the N-terminal amino acid of the light chain and/or of the N-terminal amino acid of the heavy chain is bound by an amidic bond to a molecule comprising a fluorophore group A, wherein said bond constitutes at least 70% of the total binding of said molecule to said antibody or Fab.
    Type: Application
    Filed: June 26, 2018
    Publication date: May 7, 2020
    Applicant: Alda S.r.l.
    Inventors: Alberto LUINI, Vincenzo Manuel MARZULLO, Giuseppe PALUMBO, Federica LICCARDO