Patents by Inventor Vincenzo Summa

Vincenzo Summa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20050025774
    Abstract: N-substituted 5-hydroxypyrimidin-6-one-4-carboxamides of formula (I): are described as inhibitors of HIV integrase and inhibitors of HIV replication, wherein R1, R2, R3 and R4 are defined herein. These compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are also described.
    Type: Application
    Filed: October 21, 2002
    Publication date: February 3, 2005
    Inventors: Benedetta Crescenzi, Cristina Gardelli, Ester Muraglia, Federica Orvieto, Paola Pace, Giovanna Pescatore, Alessia Petrovich, Marco Poma, Michael Rowley, Rita Scarpelli, Vincenzo Summa, Emanuela Nizi
  • Publication number: 20040106627
    Abstract: A class of 2-aryl-4,5-dihydroxy-6-carboxypyrimidines of formula (I): wherein Ar is an optionally substituted aryl or heterocyclic group; as well as compounds of formula (I) which are derivatised at one or more of the 4-hydroxy, 5-hydroxy or 6-carboxy groups; and tautomers thereof, and pharmaceutically acceptable salts or esters thereof; and inhibitors of viral polymerases, especially the hepatitis C virus (HCV) polymerase enzyme.
    Type: Application
    Filed: July 9, 2003
    Publication date: June 3, 2004
    Inventors: Cristina Gardelli, Claudio Giuliano, Steven Harper, Uwe Koch, Frank Narjes, Jesus Maria Ontoria Ontoria, Marco Poma, Simona Ponzi, Ian Stansfield, Vincenzo Summa
  • Publication number: 20030207922
    Abstract: Diketoacids of Formula A are useful as inhibitors of viral polymerases.
    Type: Application
    Filed: September 10, 2002
    Publication date: November 6, 2003
    Applicant: Istituto Di Ricerche Di Biologia Molecolare P Angeletti SPA
    Inventors: Philippe Jean Sigfried Neuner, Vincenzo Summa
  • Patent number: 6492423
    Abstract: Diketoacids of Formula (A) are useful as inhibitors of viral polymerases. In particular hepatitis C virus RNA dependent RNA polymerase (HCV RdRp), hepatitis B virus polymerase (HBV pol) and reverse transcriptase of human immunodeficiency virus (HIV RN.) The group R may be broadly chosen and is an organic moiety which contains 2 to 24 carbon atoms and includes an optionally cyclic or heterocyclic group in which the atom directly bonded to the adjacent carbonyl in the diketoacid is part of the ring structure.
    Type: Grant
    Filed: January 26, 2001
    Date of Patent: December 10, 2002
    Assignee: Istituto di Ricerche di Biologia Molecolare Pangeletti SpA
    Inventors: Altamura Sergio, Licia Tomei, Uwe Koch, Philippe Jean Sigfried Neuner, Vincenzo Summa