Abstract: Modified integrin polypeptides are provided. Methods of identifying binding agents that bind to a modified integrin polypeptide are also provided.

Abstract: Compositions and methods are provided including a plurality of analyte detection agents, each analyte detection agent includes a labile tag operatively coupled to the analyte detection agent, each labile tag includes a signal that is different from each other labile tag and each analyte detection agent targeting a different analyte.

Abstract: Compositions and methods are provided including a plurality of analyte detection agents, each analyte detection agent includes a labile tag operatively coupled to the analyte detection agent, each labile tag includes a signal that is different from each other labile tag and each analyte detection agent targeting a different analyte.

Abstract: Configurations of a system and a method for implementing a framework that optimizes the execution and deployment of operations in a computationally intensive software applications including varying complexity workloads, are described. In one aspect, a portable framework (PF) may transform an algorithmic routine developed via an IDE into an intermediate form. The PF may enable adding constraint definitions to the intermediate form of the algorithmic software routine. The PF may further enable or provision including constraint definitions, hardware architecture description and multiple optimization metrics to the intermediate form. Based on the constraint definitions, the hardware architecture description, and the multiple optimization metrics the PF may determine computing resources from multiple heterogenous hardware resources deployed on a hardware platform. The execution of the operations may be optimized by deploying the operations to be executed on the determined computing resources.

Abstract: In one embodiment, a device receives data regarding a node from a plurality of management platforms, each management platform being associated with a different access network used by the node. The device applies a unified data model to the data regarding the node received from the plurality of management platforms, to form unified data regarding the node. The device analyzes the unified data regarding the node, to generate insight information. The device provides the insight information to an application associated with a manufacturer of the node.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for training a convolutional neural network using a regularization scheme. One of the methods includes repeatedly performing the following operations: obtaining a kernel of a particular convolutional layer; applying a Fourier transform to the kernel; generating a decomposition using singular-value decomposition (SVD); generating a regularized diagonal matrix; generating a recomposition; applying an inverse Fourier transform to the recomposition; and training the convolutional neural network on training inputs.

Abstract: Modified integrin polypeptides are provided. Methods of identifying binding agents that bind to a modified integrin polypeptide are also provided.

Abstract: In one embodiment, a device receives data regarding a node from a plurality of management platforms, each management platform being associated with a different access network used by the node. The device applies a unified data model to the data regarding the node received from the plurality of management platforms, to form unified data regarding the node. The device analyzes the unified data regarding the node, to generate insight information. The device provides the insight information to an application associated with a manufacturer of the node.

Abstract: This document describes techniques for predicting spread of content across social networks. In various embodiments, user interactions with content posted to a social network are accessed during a first stage. The accessed user interactions are applied to a prediction model to predict future user interactions with the content during one or more subsequent stages.

Abstract: Compositions and methods are provided including a plurality of analyte detection agents, each analyte detection agent includes a labile tag operatively coupled to the analyte detection agent, each labile tag includes a signal that is different from each other labile tag and each analyte detection agent targeting a different analyte.

Abstract: Methods and apparatus for providing travel-related information for a location to a user based on activity indications of the user that are related to the location. The location may be determined based on a set of one or more related activity indications and a travel-related score may be determined for the location that is indicative of likelihood that the user has interest in travelling to the location. The user may be provided the travel-related information for the location based on the travel-related score.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for training a convolutional neural network using a regularization scheme. One of the methods includes repeatedly performing the following operations: obtaining a kernel of a particular convolutional layer; applying a Fourier transform to the kernel; generating a decomposition using singular-value decomposition (SVD); generating a regularized diagonal matrix; generating a recomposition; applying an inverse Fourier transform to the recomposition; and training the convolutional neural network on training inputs.

Abstract: Methods and apparatus for providing travel-related information for a location to a user based on activity indications of the user that are related to the location. The location may be determined based on a set of one or more related activity indications and a travel-related score may be determined for the location that is indicative of likelihood that the user has interest in travelling to the location. The user may be provided the travel-related information for the location based on the travel-related score.

Abstract: Systems and methods provide for network-initiated recovery from a failure during transmission of text messages (e.g., Short Message Service or SMS) sent from circuit-switched (CS)/packet-switched (PS) infrastructure to a Mobile Station or User Equipment (MS/UE) connected to a PS radio access network. A text message service center (e.g., SMS Center or SMSC) can receive a message destined for the MS/UE. The SMSC can request from a home location register (HLR) routing information to a first text message interworking function (e.g., SMS-IWF) associated with a first visitor location register (VLR). The SMSC can receive data indicating that the first SMS-IWF/VLR is unreachable. The SMSC can transmit to the HLR an indication of an absent subscriber causing the HLR to request a Mobility Management Entity (MME) to reattach the MS/UE to a second SMS-IWF/VLR. In some embodiments, the MS/UE may reattach only to the second SMS-IWF/VLR (e.g., instead of a full reattach).

Abstract: Systems and methods provide for network-initiated recovery from a failure during transmission of text messages (e.g., Short Message Service or SMS) sent from circuit-switched (CS)/packet-switched (PS) infrastructure to a Mobile Station or User Equipment (MS/UE) connected to a PS radio access network. A text message service center (e.g., SMS Center or SMSC) can receive a message destined for the MS/UE. The SMSC can request from a home location register (HLR) routing information to a first text message interworking function (e.g., SMS-IWF) associated with a first visitor location register (VLR). The SMSC can receive data indicating that the first SMS-IWF/VLR is unreachable. The SMSC can transmit to the HLR an indication of an absent subscriber causing the HLR to request a Mobility Management Entity (MME) to reattach the MS/UE to a second SMS-IWF/VLR. In some embodiments, the MS/UE may reattach only to the second SMS-IWF/VLR (e.g., instead of a full reattach).

Abstract: The following disclosure generally relates to methods of culturing podocytes in vitro. The cultures can be used for drug screening (such as medium or high throughput drug screening), and for studying molecular pathways involved in glomerular diseases. The disclosure also provides methods for analyzing the healthiness of podocytes in a cell culture. The disclosure also relates to diagnosis of kidney diseases.

Abstract: The application describes an assay for the identification of small molecule modulators of integrin CD11b/CD18 and small molecules capable of modulating activity of this receptor. Such compounds may be used in certain embodiments for treating a disease or condition selected from inflammation, immune-related disorders, cancer, ischemia-reperfusion injury, stroke, neointimal thickening associated with vascular injury, bullous pemphigoid, neonatal obstructive nephropathy, and cardiovascular disease, or in other embodiments for the treatment of a disease or condition selected from immune deficiency, acquired immune deficiency syndrome (AIDS), myeloperoxidase deficiency, Wiskott-Aldrich syndrome, chronic granulomatous disease, hyper-IgM syndromes, leukocyte adhesion deficiency, Chediak-Higashi syndrome, and severe combined immunodeficiency.

Abstract: This document describes techniques for normalizing user responses by removing behavioral bias. In one or more implementations, a response normalization model is built from user responses to one or more events. The response normalization model clusters users into behavioral classification groups based on the user responses. The response normalization model can then be used to normalize user responses by removing behavioral bias from user responses.

Abstract: A method of treating inflammation, by administering an effective amount of a ?2 integrin agonist to a patient, and reducing inflammation. A method of treating cancer, by administering an effective amount of a ?2 integrin agonist to a patient, and reducing tumor growth. A method of treating a patient exposed to radiation, by administering an effective amount of a ?2 integrin agonist to the patient after radiation exposure, and mitigating the effects of radiation exposure in the patient. A method of preventing effects of radiation, by administering an effective amount of a ?2 integrin agonist to the patient prior to radiation exposure, and preventing the effects of radiation exposure on the patient. A method of treating acquired bone marrow failure (BMF), by administering an effective amount of a ?2 integrin agonist to a patient. Methods of improving the health of damaged vasculature in a patient and activating ?2 integrins.

Abstract: The application describes small molecules capable of modulating activity of beta2 family of integrins, such as integrin CD11b/CD18 (also known as Mac-1, CR3 and ?M?2). Such compounds may be used in certain embodiments for treating a disease or condition, such as inflammation, immune-related disorders, cancer, ischemia-reperfusion injury, stroke, neointimal thickening associated with vascular injury, wound-healing, organ transplantation and cardiovascular disease, among others.