Abstract: The invention provides a stable formulation comprising an anti-EGFR antibody drug conjugate (ADC), including an anti-EGFR antibody, e.g., antibody 1, conjugated to an auristatin, e.g., MMAF, histidine, a sugar, and a surfactant.

Abstract: Refractory coatings for cutting tool applications and methods of making the same are described herein which, in some embodiments, permit incorporation of increased levels of aluminum into nitride coatings while reducing or maintaining levels of hexagonal phase in such coatings. Coatings and methods described herein, for example, employ cubic phase forming compositions for limiting hexagonal phase in nitride coatings of high aluminum content.

Abstract: Disclosed are compounds which are nuclear receptor modulators that can act as antagonists to the androgen receptor, for example, a compound of Formula I: wherein R1 to R5 and X1 to X5 are as described herein, as well as pharmaceutically acceptable salts, solvates, and stereoisomers thereof. Pharmaceutical compositions comprising such compounds, as well as methods of use, and treatment for cancers, including prostate cancers, other nuclear receptor mediated cancers, and other conditions, are also disclosed.

Abstract: The invention provides stable aqueous formulations comprising an Aqueous Stable Dual Variable Domain Immunoglobulin (AS-DVD-Ig) protein. The invention also provides stable lyophilized formulations comprising a Lyophilized Stable Dual Variable Domain Immunoglobulin (LS-DVD-Ig) protein.

Abstract: Methods of orientation imaging microscopy (OIM) techniques generally performed using transmission electron microscopy (TEM) for nanomaterials using dynamical theory is presented. Methods disclosed may use a wide angle convergent beam electron diffraction for performing OIM by generating a diffraction pattern having at least three diffraction discs that may provide additional information that is not available otherwise.

Abstract: A cable tensioning system includes a reaction frame which contains a sliding platform arranged to move linearly within the frame, and a clam-type cleat attached to the sliding platform. The cleat features one or more grooves, each of which comprises two arrays of opposing ridges that converge to form a V-shape groove adapted to receive a length of cable. The ridges of each groove are tilted relative to an axis perpendicular to the groove's longitudinal axis, such that the cable is progressively captured between the ridges of the opposing arrays as it settles into the crotch of the groove when moved in a first direction, and can be disengaged from the cleat by relaxing the axial force on the cable and moving it in the opposite direction. A linear actuator mechanism may be coupled to the sliding platform to move the platform with respect to the reaction frame.

Abstract: Compounds and methods for treating or preventing a disease, disorder or condition associated with an Nrf2-regulated pathway, including those associated with an autoimmune disease, comorbidity associated with diabetes, such as retinopathy and nephropathy, bone marrow transplant for leukemia and related cancers, bone marrow deficiencies, inborn errors of metabolism, and other immune disorders, oxidative stress, respiratory infection, ischemia, neurodegenerative disorders, radiation injury, neutropenia caused by chemotherapy, autoimmunity, and congenital neutropenic disorders, and for restoring a corticosteroid responsiveness, in a subject are provided.

Abstract: The invention includes both a method for acquiring the position of a patient's anterior pelvic plane, and a patient positioner or holder (apparatus) for securing a patient and acquiring the position of the patient's anterior pelvic plane. The method and apparatus facilitate definition of the anterior pelvic plane (APP) in the context of computer assisted hip surgery.

Abstract: Detecting and/or mitigating the presence of particle contaminants in a MEMS device involves converting benign areas in which particles might become trapped undetectably by electric fields during test to field-free regions by extending otherwise non-functional conductive shield and gate layers and placing the same electrical potential on the conductive shield and gate layers. Particle contaminants can then be moved into detection locations remote from the potential trap areas and having particle detection structures by providing some mechanical disturbance.

Abstract: A method of designing a layout of devices includes designing a layout of gate structures and diffusion regions of a plurality of devices. The method further includes identifying an edge device of the plurality of devices. The method further includes adding a dummy device next to the edge device and a dummy gate structure next to the dummy device, wherein the dummy device shares a diffusion region with the edge device, and wherein a gate structure of the dummy device is considered to be one of two dummy gate structures added next to the edge device.

Abstract: A method of manufacturing a read only memory cell includes connecting electrically a drain of the transistor to the bit line with a first conductor and a via. The method also includes generating a logic zero at a source of the transistor by electrically connecting the source of the transistor to a ground line with the first conductor. Further, the method includes, programming the read only memory cell to logic zero. A method of manufacturing a read only memory cell includes connecting electrically a drain of the transistor to the bit line with a first conductor and a via. The method also includes, connecting electrically a source of the transistor to the drain with the first conductor. Further, the method includes programming the read only memory cell to logic one.

Abstract: The invention includes a method for tracking the human scapula during shoulder surgery, by a trackable device fixed to the coracoid process of the scapula. A device of the invention allows a trackable target to be fixed to the coracoid process by bone screws and an anchor. In one embodiment, a releasable coupling is provided between the anchor and the trackable target.

Abstract: The layouts, device structures, and methods described above utilize dummy devices to extend the diffusion regions of edge structures and/or non-allowed structures to the dummy device. Such extension of diffusion regions resolves or reduces LOD and edge effect issues. In addition, treating the gate structure of a dummy device next to an edge device also allows only one dummy structure to be added next to the dummy device and saves the real estate on the semiconductor chip. The dummy devices are deactivated and their performance is not important. Therefore, utilizing dummy devices to extend the diffusion regions of edge structures and/or non-allowed structures according to design rules allows the resolution or reduction or LOD and edge effect issues without the penalty of yield reduction or increase in layout areas.

Abstract: Detecting and/or mitigating the presence of particle contaminants in a MEMS device involves including MEMS structures that in normal operation are robust against the presence of particles but which can be made sensitive to that presence during a test mode prior to use, e.g.

Abstract: A system and method for allocating jobs to an agent is disclosed. In one embodiment, a method for allocating jobs to an agent includes defining, for each job of the jobs, a job type associated with at least one job and at least one sub-step associated with the at least one job, determining eligibility to perform the at least one sub-step by an agent of agents, determining a number of jobs of each job type to be performed by the agent based on the eligibility determination, and automatically generating agent-specific job queues based on the number of jobs.

Abstract: A digital certificate associating a unique identifier for a computer-based appliance with an authentication key pair for that appliance is obtained from a certificate authority using a different, manufacturing key pair for the appliance. The manufacturing key pair may be generated by the appliance at or about its time of manufacture. The public key portion of the manufacturing key pair along with the unique identifier for the appliance may be provided via secure means to the certificate authority prior to the request for the digital certificate concerning the authentication key pair. Eventually, the digital certificate associated with the authentication key pair may be used by the appliance when joining a network, as part of a one-way or two-way authentication process.

Abstract: The invention includes a method of determining a surgical patient's pelvic position and inputting that position into a computer via a tracking system, suitable for use in navigating partial or total hip replacement surgery. The patient is first aligned with anatomical reference points in relation to corresponding locating features on a patient positioner. The positions of index features on the patient positioner are then acquired via a tracking system. Based on the positions of the index features and their known relationship to the locating features, the locations of the anatomical reference features are calculated and a pelvic plane is defined therefrom. The invention also includes a surgical tool for mounting a trackable target to a human bone, suitable for fixation to a human femur. This tool includes a removable bone clamp and a releasable coupling member, integrated with said removable bone clamp.

Abstract: Salts and crystalline forms of several salts of Varenicline, i.e., Varenicline sulfate: are provided, along with methods of preparing the solid states and processes for preparing Varenicline base from those Varenicline salts.

Abstract: The layouts, device structures, and methods described above utilize dummy devices to extend the diffusion regions of edge structures and/or non-allowed structures to the dummy device. Such extension of diffusion regions resolves or reduces LOD and edge effect issues. In addition, treating the gate structure of a dummy device next to an edge device also allows only one dummy structure to be added next to the dummy device and saves the real estate on the semiconductor chip. The dummy devices are deactivated and their performance is not important. Therefore, utilizing dummy devices to extend the diffusion regions of edge structures and/or non-allowed structures according to design rules allows the resolution or reduction or LOD and edge effect issues without the penalty of yield reduction or increase in layout areas.

Abstract: Methods of orientation imaging microscopy (OIM) techniques generally performed using transition electron microscopy (TEM) for nanomaterials using dynamical theory is presented. Methods disclosed may use a wide angle convergent beam electron diffraction for performing OIM by generating a diffraction pattern having at least three diffraction discs that may provide additional information that is not available otherwise.