Abstract: Color handles are generated based on digital image color gradients using machine learning. In order to train a neural network of a generator module of a GAN system, a training digital image is used by the neural network of the generator module to generate a candidate color handle. The discriminator module of the GAN system then compares the candidate color handle with a ground truth color handle of the training digital image using a loss function as part of machine learning, and uses a result of this comparison to train the neural network of the generator module.

Abstract: Embodiments of the present invention relate to 6-6 bicyclic aromatic ring substituted nucleoside analogues, including, for example, the following compound: Embodiments of the present invention also relate to uses of the disclosed compounds for the inhibition of protein arginine methyltransferase 5 (PRMT5).

Abstract: An endoscopy video feature enhancement platform (EVFEP) is connected to the output of any type endoscope system, and inputs and captures the output video. The video is visually augmented live with indicators of possible polyp detection and localization, polyp attributes, and procedure metrics, based on the collective learning of the output results of many different types of endoscopy systems on a large scale. An artificial intelligence model is trained on confirmed polyp detection previously determined by this and other EVFEP devices used with many different types of endoscope systems on a large scale. Augmented video, images and automatically generated short video clips of key procedure segments are passed to a reporting system, and supplemented with meta data.

Abstract: A method, apparatus, and system for periodic performance optimization through heatmap based management of an in-memory area are provided. A heatmap is maintained to track database accesses, and a sliding most recent time window of the heatmap is externalized to a desired granularity level to provide access statistics regarding candidate elements to be possibly placed in the in-memory area. Initially and on a periodic basis, an appropriate knapsack algorithm is chosen based on an analysis on the computational costs versus the benefits of applying various knapsack algorithms for the candidate elements. Using the chosen algorithm in conjunction with a selected performance model, an optimized configuration of the in-memory area is determined. The optimized configuration indicates a set of elements chosen from the candidate elements, optionally specified with compression levels.

Abstract: An apparatus, system and method for managing airspace for unmanned aerial vehicles (UAVs). The apparatus, system and method may include a platform comprising at least records of certified administratively acceptable requestors of restricted use of the airspace for UAVs, a plurality of airspace management rules for UAVs, and a broadcaster for providing notifications over at least one telecommunications network; and a plurality of applications, each instantiated by a processor on one of a plurality of corresponded devices by non-transitory computing code, wherein the plurality of corresponded devices comprises at least a plurality of mobile devices. A first of the plurality of applications may be capable of receiving the restricted UAV use request from a requestor within a physical area of the restricted UAV use request, and of forwarding the restricted UAV use request and an identification of the requestor to the platform over the at least one telecommunications network.

Abstract: Automatic bone handle generation for efficient manipulation of a graphic object is described. Initially, a request is received to generate bone handles for a graphic object. Responsive to the request, a bone handle generation system determines an outline of the graphic object. Based on the outline, this system then generates a mesh corresponding to the graphic object. The bone handle generation system contracts this mesh inward to form a contracted mesh. By then collapsing edges of the contracted mesh, the bone handle generation system generates a set of connected line segments forming a skeleton of the graphic object. The bone handle generation system reduces the set of connected line segments by removing line segments and by merging vertices that connect different line segments. Based on this reduction, the bone handle generation system obtains the bone handles, which are controllable with user input to deform corresponding portions of the graphic object.

Abstract: Wireless network interfaces that are capable of transmitting and/or receiving beamformed radiofrequency (RF) signals may be assisted by the use of codebooks. Electronic devices with memory to store a database of codebooks may be used to increase the number of entries available for operation. The database of codebooks may employ environmental parameters to improve efficiency of the wireless network interface. Methods for calibration of electronic devices and/or adjustment and selection of codebooks based on the parameters are also described. The calibration may employ a testing chamber that measure powers at in a limited number of angles.

Abstract: ?-NETA analogs are provided for the treatment of inflammatory disease.

Abstract: In one aspect, a computerized method for automatically generating digital video content from scripts includes a media engine. The media engine receives a script and a plurality of flags; sending the script to a natural language processing (NLP) engine. The NLP engine parses the script. The script is broken into a set of keywords and phrases in a JSON format. The NLP engine, based on the keywords and phrases and the plurality of flags, obtains a relevant background scene for the video and a relevant set of assets for the video, and a set of associated attributes of each of the set of assets. In an asset is a character or object for the video. The NLP engine provides the parsed script in the JSON format and the relevant background scene of the video and the relevant set of assets of the video, and the set of associated attributes of each of the set of assets to a layout engine.

Abstract: The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to azepane compounds, pharmaceutical composition comprising such compounds, and their use as menin/MLL protein/protein interaction inhibitors, useful for treating diseases such as cancer, myelodysplastic syndrome (MDS) and diabetes.

Abstract: The present invention relates to subcutaneous formulations of anti-CD38 antibodies and their uses.

Abstract: An endoscopy video feature enhancement platform (EVFEP) is connected to the output of any type endoscope system, and inputs and captures the output video. The video is visually augmented live with indicators of possible polyp detection and localization, polyp attributes, and procedure metrics, based on the collective learning of the output results of many different types of endoscopy systems on a large scale. An artificial intelligence model is trained on confirmed polyp detection previously determined by this and other EVFEP devices used with many different types of endoscope systems on a large scale. Augmented video, images and automatically generated short video clips of key procedure segments are passed to a reporting system, and supplemented with meta data.

Abstract: Generation of a multi-state symbol from an input graphic object is described. A multi-state graphic symbol system generates an outline and a base mesh for a graphic object. The multi-state graphic symbol system then defines graphic manipulation handles relative to the base mesh and deforms the base mesh by altering a state of the handles. Vectors describing initial positions and final positions of the handles are generated and stored with the outline and base mesh to define the graphic object's multi-state symbol. Additional poses can be generated by adding and/or modifying other handles, and each additional pose is stored as a vector in the multi-state symbol. Additional poses of the graphic object can be generated by interpolating between different vectors of the multi-state symbol. The multi-state graphic symbol system additionally enables for an interpolated pose to be generated based on separate user-defined paths for different handles of the multi-state symbol.

Abstract: A method of obtaining contextually relevant content by a wireless communications device is provided. The method may comprise obtaining, by a wireless communications device (WCD), a destination device identifying item, transmitting the destination device identifying item to a contextual content server, wherein the contextual content server determines one or more contextually relevant content items by processing the received destination device identifying item and a WCD location value, and receiving, from the contextual content server, at least one of the one or more contextually relevant content items.

Abstract: In one aspect, coated cutting tools are described herein comprising a substrate and a coating comprising a refractory layer deposited by physical vapor deposition adhered to the substrate, the refractory layer comprising M1?xAlxN wherein x?0.68 and M is titanium, chromium or zirconium, the refractory layer including a cubic crystalline phase and having hardness of at least 25 GPa.

Abstract: The present invention provides for novel metabolic pathways leading to propanol, alcohol or polyol formation in a consolidated bioprocessing system (CBP), where lignocellulosic biomass is efficiently converted to such products. More specifically, the invention provides for a recombinant microorganism, where the microorganism expresses one or more native and/or heterologous enzymes; where the one or more enzymes function in one or more engineered metabolic pathways to achieve: (1) conversion of a carbohydrate source to 1,2-propanediol, isopropropanol, ethanol and/or glycerol; (2) conversion of a carbohydrate source to n-propanol and isopropanol; (3) conversion of a carbohydrate source to isopropanol and methanol; or (4) conversion of a carbohydrate source to propanediol and acetone; wherein the one or more native and/or heterologous enzymes is activated, upregulated or downregulated.

Abstract: In accordance with an embodiment, described herein is a system and method for providing security services using a security configuration template in a multi-tenant environment. The system can load a security configuration template in memory when the multi-tenant environment starts, and can use the security configuration template to create a multi-headed tree to represent tenant-specific security configurations. Each head of the multi-headed tree can represent a root node of either the security configuration template or a tenant-specific security configuration. Each tenant-specific security configuration can reuse one or more nodes in the security configuration template by referencing those nodes, and can include one or more new nodes created from the security configuration template by replacing each placeholder therein with tenant-specific values.

Abstract: The present invention describes a new method for creating hybrid edge seals using metal, alloy, powder coated metal and other conductive surfaces in between two substrates. The methods utilize various materials, seal designs, and geometries of hybrid seals based on polymeric powder coatings and glass powder coatings.

Abstract: A Virtual Cloud Exchange (VCX) and method for establishing connectivity between a host computer in a customer network and a cloud service provider, includes a customer facing software defined network (SDN) switch; a cloud computing service facing SDN switch; and a processor executing instructions to generate a customer facing network routing virtual network function (VNF) and a cloud facing network routing VNF; and configure a first open virtual switch (vSwitch) and a second open vSwitch. The customer facing SDN switch generates a first overlay tunnel between the customer facing SDN switch and the first open vSwitch and the cloud facing SDN switch generates a second overlay tunnel between the cloud facing SDN switch and the second open vSwitch.

Abstract: A shapeable passer for surgical cable or suture is made from a flexible tubular extrusion which includes at least one lumen arranged to receive the leading end of a surgical cable or suture, and at least one lumen arranged to contain a malleable stiffener element. The lumens and stiffener element are arranged parallel to each other and lengthwise along longitudinal axis of the extrusion, such that the malleable stiffener element enables the malleable portion of the passer to be shaped as desired. The leading ends of the lumens are preferably sealed, capped or tipped, while the trailing ends of the lumens arranged to receive the surgical cables or sutures are preferably flared to facilitate manual insertion of the cables or sutures.