Abstract: Systems, methods, and computer program products are provided herein for data synchronization and replication in distributed networks. An example method includes monitoring performance of operations on a source computing cluster that are associated with one or more applications and replicating data entries associated with the operations on a data recovery computing cluster communicably coupled with the source computing cluster. The method further includes determining an outage condition associated with the source computing cluster and determining a first operation whose execution is pending on the source computing cluster. The first operation also include first execution characteristics defining instructions for performance of the first operation as related to at least a first application. The method also include executing the first operation on the data recovery computing cluster based on the one or more first execution characteristics.

Abstract: This invention relates to the use of (4-benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl]methanone (NSI-189) or a pharmaceutically acceptable salt thereof in the treatment of a psychiatric condition in which depressive symptoms are prominent, including major depressive disorder, bipolar disorder, posttraumatic stress disorder, substance use disorder, and depression-related aspects of schizophrenia (e.g. negative symptoms), in a patient who is cognitively impaired or has poor or slow cognition or difficulty making decisions or exhibits certain EEG properties. The present invention also relates to the selection of patients with a biomarker (e.g., EEG) and/or clinical symptoms who would most benefit from such compounds.

Abstract: Systems, methods, and computer program products are provided herein for data synchronization and replication in distributed networks. An example method includes monitoring performance of operations on a source computing cluster that are associated with one or more applications and replicating data entries associated with the operations on a data recovery computing cluster communicably coupled with the source computing cluster. The method further includes determining an outage condition associated with the source computing cluster and determining a first operation whose execution is pending on the source computing cluster. The first operation also include first execution characteristics defining instructions for performance of the first operation as related to at least a first application. The method also include executing the first operation on the data recovery computing cluster based on the one or more first execution characteristics.

Abstract: This invention relates to the use of (4-benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl]methanone (NSI-189) or a pharmaceutically acceptable salt thereof in the treatment of a psychiatric condition in which depressive symptoms are prominent, including major depressive disorder, bipolar disorder, posttraumatic stress disorder, substance use disorder, and depression-related aspects of schizophrenia (e.g. negative symptoms), in a patient who is cognitively impaired or has poor or slow cognition or difficulty making decisions or exhibits certain EEG properties. The present invention also relates to the selection of patients with a biomarker (e.g., EEG) and/or clinical symptoms who would most benefit from such compounds.

Abstract: This invention relates to the use of (4-benzylpiperazin-1-yl)-[2-(3-methylbutylamino) pyridin-3-yl]methanone (NSI-189) or a pharmaceutically acceptable salt thereof in the treatment of a psychiatric condition in which depressive symptoms are prominent, including major depressive disorder, bipolar disorder, posttraumatic stress disorder, substance use disorder, and depression-related aspects of schizophrenia (e.g. negative symptoms), in a patient who is cognitively impaired or has poor or slow cognition or difficulty making decisions or exhibits certain EEG properties. The present invention also relates to the selection of patients with a biomarker (e.g., EEG) and/or clinical symptoms who would most benefit from such compounds.

Abstract: This invention relates to the use of (4-benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl]methanone (NSI-189) or a pharmaceutically acceptable salt thereof in the treatment of a psychiatric condition in which depressive symptoms are prominent, including major depressive disorder, bipolar disorder, posttraumatic stress disorder, substance use disorder, and depression-related aspects of schizophrenia (e.g. negative symptoms), in a patient who is cognitively impaired or has poor or slow cognition or difficulty making decisions or exhibits certain EEG properties. The present invention also relates to the selection of patients with a biomarker (e.g., EEG) and/or clinical symptoms who would most benefit from such compounds.

Abstract: This invention relates to the use of (4-benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl]methanone (NSI-189) or a pharmaceutically acceptable salt thereof in the treatment of a psychiatric condition in which depressive symptoms are prominent, including major depressive disorder, bipolar disorder, posttraumatic stress disorder, substance use disorder, and depression-related aspects of schizophrenia (e.g. negative symptoms), in a patient who is cognitively impaired or has poor or slow cognition or difficulty making decisions or exhibits certain EEG properties. The present invention also relates to the selection of patients with a biomarker (e.g., EEG) and/or clinical symptoms who would most benefit from such compounds.

Abstract: A system includes a memory and a processor. The processor is configured to access one or more configuration logs generated by a computing cluster. The processor is further configured to determine, by analyzing the one or more configuration logs, a particular service running on the computing cluster that has generated a plurality of errors within the plurality of log messages. The processor is further configured to determine whether the particular error has previously occurred. The processor is further configured to, in response to determining that the particular error has previously occurred, generate and send one or more commands to the computing cluster. The one or more commands are operable to change a current configuration value for the particular service running on the computing cluster to a new configuration value. The new configuration value is based on a historical value stored in the database of historical configuration errors.

Abstract: Examples describe a duty cycle correction circuit for correcting duty cycle distortion from memory. One example is an integrated circuit for correcting an input clock signal. The integrated circuit includes a first leg circuit and a second leg circuit. The first leg circuit and the second leg circuit both comprise a charging circuit and a discharging circuit. Each charging circuit comprises a first plurality of transistors and each discharging circuit comprises a second plurality of transistors. The charging circuit is coupled to the discharging circuit in series. A number of transistors of the first plurality of transistors in the first leg circuit is different from a number of transistors of the first plurality of transistors in the second leg circuit.

Abstract: A system includes a memory and a processor. The processor is configured to access one or more configuration logs generated by a computing cluster. The processor is further configured to determine, by analyzing the one or more configuration logs, a particular service running on the computing cluster that has generated a plurality of errors within the plurality of log messages. The processor is further configured to determine whether the particular error has previously occurred. The processor is further configured to, in response to determining that the particular error has previously occurred, generate and send one or more commands to the computing cluster. The one or more commands are operable to change a current configuration value for the particular service running on the computing cluster to a new configuration value. The new configuration value is based on a historical value stored in the database of historical configuration errors.

Abstract: A system includes a memory and a processor. The processor is configured to access one or more configuration logs generated by a computing cluster. The processor is further configured to determine, by analyzing the one or more configuration logs, a particular service running on the computing cluster that has generated a plurality of errors within the plurality of log messages. The processor is further configured to determine whether the particular error has previously occurred. The processor is further configured to, in response to determining that the particular error has previously occurred, generate and send one or more commands to the computing cluster. The one or more commands are operable to change a current configuration value for the particular service running on the computing cluster to a new configuration value. The new configuration value is based on a historical value stored in the database of historical configuration errors.

Abstract: Examples describe a duty cycle correction circuit for correcting duty cycle distortion from memory. One example is an integrated circuit for correcting an input clock signal. The integrated circuit includes a first leg circuit and a second leg circuit. The first leg circuit and the second leg circuit both comprise a charging circuit and a discharging circuit. Each charging circuit comprises a first plurality of transistors and each discharging circuit comprises a second plurality of transistors. The charging circuit is coupled to the discharging circuit in series. A number of transistors of the first plurality of transistors in the first leg circuit is different from a number of transistors of the first plurality of transistors in the second leg circuit.

Abstract: This invention relates to the use of (4-benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl]methanone (NSI-189) or a pharmaceutically acceptable salt thereof in the treatment of a psychiatric condition in which depressive symptoms are prominent, including major depressive disorder, bipolar disorder, posttraumatic stress disorder, substance use disorder, and depression-related aspects of schizophrenia (e.g. negative symptoms), in a patient who is cognitively impaired or has poor or slow cognition or difficulty making decisions or exhibits certain EEG properties. The present invention also relates to the selection of patients with a biomarker (e.g., EEG) and/or clinical symptoms who would most benefit from such compounds.

Abstract: Apparatus and associated methods relate to an I/O bank impedance calibration circuit having (a) a replica master resistor coupled to an external precision resistor, and (b) a control circuit configured to calibrate an output impedance of the master resistor to generate a calibrated code to control a replica slave resistor in each bank. In an illustrative example, a signal applied to the replica master resistor may be compared against a programmable reference signal. The control circuit may generate the calibrated code, in response to the comparison result, to calibrate the output impedance of the replica master resistor. By implementing the replica master resistor and the replica slave resistor, impedances of a large number of IOs or banks may be calibrated by the impedance calibration circuit using a single one reference pin.