Patents by Inventor Vinod Kumar Chandukudlu House

Vinod Kumar Chandukudlu House has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes for the preparation of AZD5363 and intermediate used therein
    Patent number: 9879017
    Abstract: There is provided a process for the preparation of AZD5363, or a salt of AZD5363, comprising: (a) the reaction of 8-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3-oxa-1,8-diazaspiro[4.5]decane-2,4-dione: or a salt thereof, with (S)-3-amino-3-(4-chlorophenyl)propan-1-ol, or a salt thereof, in the presence of base; and (b) either isolating AZD5363 or isolating AZD5363 as a salt. 8-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3-oxa-1,8-diazaspiro[4.5]decane-2,4-dione is provided and is prepared by reacting 4-(alkyloxycarbonylamino)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxylic acid, or a salt thereof, with a cyclizing agent.
    Type: Grant
    Filed: May 26, 2015
    Date of Patent: January 30, 2018
    Assignee: AstraZeneca AB
    Inventors: Sanjeev Kumar Aavula, Vinod Kumar Chandukudlu House, Anil Chikkulapalli, Karthikeyan Chinnakalai
  • Processes for the Preparation of AZD5363 and Novel Intermediate Used Therein
    Publication number: 20170210745
    Abstract: There is provided a process for the preparation of AZD5363, or a salt of AZD5363, comprising: (a) the reaction of 8-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3-oxa-1,8-diazaspiro[4.5]decane-2,4-dione: or a salt thereof, with (S)-3-amino-3-(4-chlorophenyl)propan-1-ol, or a salt thereof, in the presence of base; and (b) either isolating AZD5363 or isolating AZD5363 as a salt. 8-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3-oxa-1,8-diazaspiro[4.
    Type: Application
    Filed: May 26, 2015
    Publication date: July 27, 2017
    Applicant: AstraZeneca AB
    Inventors: Sanjeev Kumar Aavula, Vinod Kumar Chandukudlu House, Anil Chikkulapalli, Karthikeyan Chinnakalai