Abstract: An umbrella has a lower pole and an upper pole and a fabric. The lower pole includes screw threads. A spring clip in an inverted V-shaped configuration has outwardly extending projections removably coupling together the upper pole and the lower pole. A handle is removably coupled to the lower pole to twist the lower pole. Each rib of a plurality of ribs has an interior end and an exterior end. The interior ends of the ribs are coupled to the upper pole. The fabric overlies the ribs. Each tip of a plurality of tips has an upper part and a lower part. Each upper part has a tubular recess receiving the exterior end of an associated rib. The periphery of the fabric is secured between the upper part and the lower part.

Abstract: Systems and techniques are disclosed for determining an intervention for a patient based at least in part on a likelihood of the patient to adhere to a prescription. In some implementations, a patient profile for a patient is obtained from one or more computer-readable storage devices in a patient population, the patient profile including multiple patient attributes; an adherence score is obtained for the patient profile, the adherence score for predicting patient adherence based on one or more of the multiple patient attributes wherein the adherence score indicates a likelihood of adherence of the patient to a prescribed treatment; and the adherence score obtained for the patient profile is modified into a modified score for intervention based on a set of weights for weighting the patient attributes.

Abstract: A method and device for the treatment of hypertrophic cardiomyopathy. The device includes a cutting device for resection of a thickened myocardium. The operator positions the cutting device adjacent to the myocardium that is to be resected and then slides a tubular blade within an outer shell of the cutting device to resect the septum.

Abstract: Systems and techniques are disclosed for determining a health risk assessment score for a patient who did not complete a health risk assessment. In some implementations, the health risk assessment score can be determined for the patient who did not respond based on a behavior prediction score obtained for the patient who did not respond, behavior prediction scores for patients who did respond to the health risk assessment, and health risk assessment scores for the patients who did respond.

Abstract: The umbrella includes a shaft, a lower canopy having a central opening, and an upper canopy thereabove over the opening. A first supporting assembly includes ribs, stretchers, and a runner and is connected to the shaft and first and second canopies to operably move the canopies between closed and open positions, wherein an inner portion of the upper canopy moves with the ribs. A second supporting assembly is connected to the ribs of the first assembly within the opening and connected to an outer portion of the upper canopy for operably moving the outer portion of the upper canopy between concave and convex positions while the lower canopy and inner portion of the upper canopy are retained in the concave position, such that the outer portion of the upper canopy covers the opening when concave to restrict air passage and exposes the opening when convex to permit air passage.

Abstract: Systems, methods and devices for modifying a patient adherence score which include, in one implementation, obtaining a patient profile in a patient population, the patient profile including multiple patient attributes and each patient attribute including a value; obtaining an adherence score for the patient profile for predicting patient adherence based on one or more of the multiple patient attributes wherein the adherence score indicates a likelihood of adherence of the patient to the prescribed treatment; and applying a modifier associated with an application to modify the adherence score obtained for the patient profile into a modified score for the application.

Abstract: In one aspect, the present invention is directed to an apparatus and method for treating congestive heart failure that restores kidney renal functions by artificial perfusion of at least one kidney. In one aspect, a catheter inserted into the aorta of the patient has an outlet port that supplies the patient's blood obtained from a patient's aorta into an adjoining renal artery of the patient to perfuse the kidney. The catheter comprises a rotor housed inside a portion of the catheter to supply the blood to the kidney at a desired pressure. The restoration of kidney function assists the heart by removing excess fluid, urine and toxin from the patient, and by normalizing the patient's renin-angiotensin system and other neurohormonal substances.

Abstract: Systems and techniques are disclosed for determining a health risk assessment score for a patient who did not complete a health risk assessment. In some implementations, the health risk assessment score can be determined for the patient who did not respond based on a behavior prediction score obtained for the patient who did not respond, behavior prediction scores for patients who did respond to the health risk assessment, and health risk assessment scores for the patients who did respond.

Abstract: Behavior predication scores of patients can be aggregated for a physician, a group of physicians, or a health care plan. In some embodiments, social health network data can be obtained for a social health network of health care professionals, the social network data including relationships between the health care professionals; behavior prediction scores can be obtained for patients of a health care professional in the network; the behavior predication scores of the patients of the health care professional can be aggregated to determine an aggregate score for the health care professional; and an influence score for the health care professional can be generated based on the aggregate score.

Abstract: System and techniques are disclosed for determining a recommended prescription. In some examples, a recommended prescription can be determined by obtaining a behavior prediction score for a patient, wherein the behavior prediction score is based at least in part on a likelihood of adherence of the patient to a prescribed treatment; and determining a recommended prescription, from various previously provided prescriptions, based on the behavior prediction score and prescription scores of the various previously provided prescriptions; and providing the recommended prescription for display. The prescription scores can indicate a likely effect of the various previously provided prescriptions on adherence.

Abstract: Systems and techniques are disclosed for determining an intervention for a patient based at least in part on a likelihood of the patient to adhere to a prescription. In some implementations, a patient profile for a patient is obtained from one or more computer-readable storage devices in a patient population, the patient profile including multiple patient attributes; an adherence score is obtained for the patient profile, the adherence score for predicting patient adherence based on one or more of the multiple patient attributes wherein the adherence score indicates a likelihood of adherence of the patient to a prescribed treatment; and the adherence score obtained for the patient profile is modified into a modified score for intervention based on a set of weights for weighting the patient attributes.

Abstract: Systems, methods and devices for modifying a patient adherence score which include, in one implementation, obtaining a patient profile in a patient population, the patient profile including multiple patient attributes and each patient attribute including a value; obtaining an adherence score for the patient profile for predicting patient adherence based on one or more of the multiple patient attributes wherein the adherence score indicates a likelihood of adherence of the patient to the prescribed treatment; and applying a modifier associated with an application to modify the adherence score obtained for the patient profile into a modified score for the application.

Abstract: In one aspect, the present invention is directed to an apparatus and method for treating congestive heart failure that restores kidney renal functions by artificial perfusion of at least one kidney. In one aspect, a catheter inserted into the aorta of the patient has an outlet port that supplies the patient's blood obtained from a patient's aorta into an adjoining renal artery of the patient to perfuse the kidney. The catheter comprises a rotor housed inside a portion of the catheter to supply the blood to the kidney at a desired pressure. The restoration of kidney function assists the heart by removing excess fluid, urine and toxin from the patient, and by normalizing the patient's renin-angiotensin system and other neurohormonal substances.

Abstract: The present invention relates to chemical compounds having a general formula I wherein A, B, C1, C2, D, L1, L2 and R3-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Tie-2 and Aurora kinase enzymes thereby influencing angiogenesis and the process of cell cycle and cell proliferation, respectively, to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of various protein kinases.

Abstract: In one aspect, the present invention is directed to an apparatus and method for treating congestive heart failure that restores kidney renal functions by artificial perfusion of at least one kidney. In one aspect, a catheter inserted into the aorta of the patient has an outlet port that supplies the patient's blood obtained from a patient's aorta into an adjoining renal artery of the patient to perfuse the kidney. The catheter comprises a rotor housed inside a portion of the catheter to supply the blood to the kidney at a desired pressure. The restoration of kidney function assists the heart by removing excess fluid, urine and toxin from the patient, and by normalizing the patient's renin-angiotensin system and other neurohormonal substances.

Abstract: The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A, B, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.

Abstract: The present invention relates to chemical compounds having a general formula I wherein A1, A2, C1, C2, D, L1, L2, Z and R1- are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.

Abstract: The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A, B, W, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.

Abstract: Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.