Abstract: A polymer modified porous substrate for solid phase extraction or chromatography, comprising a porous substrate and a polymeric monolith formed thereon, wherein the polymeric monolith comprises C5-10 monocyclic or bicyclic aryl or heteroaryl, optionally substituted with -L-Qp-Rq; where q is 0-3, p is 0-5, Q is —NRC(O)—, —C(O)NR—, —OC(O)NR—, —OC(O)R—, —NRC(O)O—, —NRC(O)NR—, —NCO, —CHOHCHOH—, CH2OCHCH2O—, —(CH2CH2O)s—, —(CH2CH2CH2O)s—, —C(O)—, —C(O)O—, —CH2C(O)CH2—, —S—, —SS—, —CHOH—, —O—, —SO—, —SO2—, —SO3—, —OSO3, —SO2NR—, —NRq—, and —NRq+—, —CN, —NC, —CHOCH—, —NHC(NH)NH—, —NO2, —NO, —OPO3—, —OH; and R is hydrogen, C5-10 monocyclic or bicyclic aryl or heteroaryl, C1-12 branched, unbranched, or cyclic hydrocarbyl; L is a bond or a C1-12 branched, unbranched, or cyclic hydrocarbyl. Methods of preparing and using the polymer modified porous substrates are disclosed.

Abstract: A polymer modified porous substrate for solid phase extraction or chromatography, comprising a porous substrate and a polymeric monolith formed thereon, wherein the polymeric monolith comprises C5-10 monocyclic or bicyclic aryl or heteroaryl, optionally substituted with -L-Qp-Rq; where q is 0-3, p is 0-5, Q is —NRC(O)—, —C(O)NR—, —OC(O)NR—, —OC(O)R—, —NRC(O)O—, —NRC(O)NR—, —NCO, —CHOHCHOH—, CH2OCHCH2O—, —(CH2CH2O)s—, —(CH2CH2CH2O)s—, —C(O)—, —C(O)O—, —CH2C(O)CH2—, —S—, —SS—, —CHOH—, —O—, —SO—, —SO2—, —SO3—, —OSO3, —SO2NR—, —NRq—, and —NRq+—, —CN, —NC, —CHOCH—, —NHC(NH)NH—, —NO2, —NO, —OPO3—, —OH; and R is hydrogen, C5-10 monocyclic or bicyclic aryl or heteroaryl, C1-12 branched, unbranched, or cyclic hydrocarbyl; L is a bond or a C1-12 branched, unbranched, or cyclic hydrocarbyl. Methods of preparing and using the polymer modified porous substrates are disclosed.

Abstract: Halogenated polymers of vinyl aromatic monomers comprising styrene and divinylbenzene are provided for use in a chromatographic separation method of analytes, wherein said polymer further comprises a hydrocarbyl or halocarbyl substituent comprising from 1 to 1,000,000 carbon atoms, or combinations thereof. Methods of using the halogenated polymers are also provided. The polymers and methods are particularly useful in the separation of nucleic acids labeled with hydrophobic labels such as protecting groups, fluorophores, and the like.

Abstract: A polymeric sorbent that can be employed in the extraction and purification of polar and nonpolar molecules from a complex media (e.g. pharmaceuticals from biological matrices) by solid phase extraction (SPE). The sorbent exhibits a strong capacity for the retention of polar molecules and can facilitate the recovery of compounds possessing a range of polarities while furnishing clean extracts showing low ion suppression. The polymer is wettable and remains wetted over long periods of time.

Abstract: A polymeric sorbent that can be employed in the extraction and purification of polar and nonpolar molecules from a complex media (e.g. pharmaceuticals from biological matrices) by solid phase extraction (SPE). The sorbent exhibits a strong capacity for the retention of polar molecules and can facilitate the recovery of compounds possessing a range of polarities while furnishing clean extracts showing low ion suppression. The polymer is wettable and remains wetted over long periods of time.

Abstract: A polymeric sorbent that can be employed in the extraction and purification of polar and nonpolar molecules from a complex media (e.g. pharmaceuticals from biological matrices) by solid phase extraction (SPE). The sorbent exhibits a strong capacity for the retention of polar molecules and can facilitate the recovery of compounds possessing a range of polarities while furnishing clean extracts showing low ion suppression. The polymer is wettable and remains wetted over long periods of time.