Patents by Inventor Vireak Thon

Vireak Thon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PmST3 enzyme for chemoenzymatic synthesis of alpha-2-3-sialosides
    Patent number: 9783838
    Abstract: The present invention provides novel methods for preparing glycosylated molecules such as oligosaccharides, glycolipids, and glycoproteins/peptides. Novel sialyltransferases are also disclosed. The method includes forming a reaction mixture containing an acceptor molecule, a donor substrate having a sugar moiety and a nucleotide, and a sialyltransferase selected from PmST3 (SEQ ID NO:7) and certain variants thereof. The reaction mixture is formed under conditions sufficient to transfer the sugar moiety from the donor substrate to the acceptor molecule, thereby forming the glycosylated molecule. In some embodiments, the acceptor molecule is selected from a natural product, an oligosaccharide, a glycoprotein, and a glycolipid. In some embodiments, the donor substrate is formed via conversion of a suitable hexosamine derivative to a cytidine 5?-monophosphate(CMP)-sialic acid in a one-pot reaction mixture containing asialic acid aldolase and a CMP-sialic acid synthetase.
    Type: Grant
    Filed: November 7, 2012
    Date of Patent: October 10, 2017
    Assignee: The Regents of the University of California
    Inventors: Xi Chen, Vireak Thon, Hai Yu
  • PmST2 enzyme for chemoenzymatic synthesis of ?-2-3-sialylglycolipids
    Patent number: 9102967
    Abstract: The present invention provides novel methods for preparing glycolipid products. Novel sialyltransferases are also disclosed.
    Type: Grant
    Filed: January 11, 2013
    Date of Patent: August 11, 2015
    Assignee: The Regents of the University of California
    Inventors: Xi Chen, Vireak Thon, Kam Lau
  • PmST3 ENZYME FOR CHEMOENZYMATIC SYNTHESIS OF ALPHA-2-3-SIALOSIDES
    Publication number: 20140349339
    Abstract: The present invention provides novel methods for preparing glycosylated molecules such as oligosaccharides, glycolipids, and glycoproteins/peptides. Novel sialyltransferases are also disclosed. The method includes forming a reaction mixture containing an acceptor molecule, a donor substrate having a sugar moiety and a nucleotide, and a sialyltransferase selected from PmST3 (SEQ ID NO:7) and certain variants thereof. The reaction mixture is formed under conditions sufficient to transfer the sugar moiety from the donor substrate to the acceptor molecule, thereby forming the glycosylated molecule. In some embodiments, the acceptor molecule is selected from a natural product, an oligosaccharide, a glycoprotein, and a glycolipid. In some embodiments, the donor substrate is formed via conversion of a suitable hexosamine derivative to a cytidine 5?- monophosphate(CMP)-sialic acid in a one-pot reaction mixture containing asialic acid aldolase and a CMP-sialic acid synthetase.
    Type: Application
    Filed: November 7, 2012
    Publication date: November 27, 2014
    Inventors: Xi Chen, Vireak Thon, Hai Yu