Patents by Inventor Virendra B. Mahesh

Virendra B. Mahesh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthetic piperidinediones with cytostatic activity
    Patent number: 5238947
    Abstract: The present invention are novel compounds of the formula: ##STR1## wherein R is OH, NH.sub.2, OW, or H; X is H, F, Cl, Br, I, OH, OW, NO.sub.2 or NH.sub.2 ; Y is H, F, Cl, I, or Br; W is C(O)Z or a C.sub.1 to C.sub.12 alkyl group; Z is an aliphatic or aromatic group of from C.sub.1 to C.sub.12 ; X and Y can both vary within the molecule; and if R is H, at least one of X or Y is not H. In a preferred embodiment, R is OH or NH.sub.2. The most preferred compound is (4-hydroxy-3-N-phenylacetylamino-2,6-piperidinedione), in which R is OH, X is H and Y is H. These compounds have cytostatic activity and insert stereochemically into DNA.
    Type: Grant
    Filed: May 21, 1991
    Date of Patent: August 24, 1993
    Assignees: University of Georgia Research Foundation, Inc., Stereochemical Genetics, Inc.
    Inventors: Lawrence B. Hendry, Chung K. Chu, Virendra B. Mahesh