Abstract: A pressure-adherent silicone elastomer composition comprising a homogeneous mixture of a silicone pressure sensitive adhesive composition, a crosslinkable silicone elastomer composition, and, optionally, a viscosity reducing agent. Specifically, the silicone pressure sensitive adhesive composition is a condensation product, having a plasticity of less than 200 mils, of a benzene-soluble resinous copolymer containing silicon-bonded hydroxyl radicals and consisting essentially of triorganosiloxy units of the formula R.sub.3 SiO.sub.1/2 and tetrafunctionalsiloxy units of the formula SiO.sub.4/2 in a ratio of about 0.6 to 0.9 triorganosiloxy units for each tetrafunctionalsiloxy unit present in the copolymer and a polydiorganosiloxane having a viscosity from 100 centipoise to 50,000 centipoise at 25.degree. C.

Abstract: This invention relates to an improved transdermal drug delivery device for the controlled transdermal delivery of amino-functional drugs. The improvement resides in providing the device with a silicone pressure-sensitive adhesive layer which has been chemically treated to reduce the silicon-bonded hydroxyl content of the pressure-sensitive adhesive composition to render the adhesive layer resistant to loss of tack and preserve the instant adherence of the device to the skin of a wearer during storage and while the device is being worn. Preferably, the composition used comprises a silicon-bonded hydroxyl radical containing resinous copolymer of R.sub.3 SiO.sub.1/2 units and SiO.sub.4/2 units and a polydiorganosiloxane which have been chemically treated with R.sub.3 SiO.sub.1/2 units where R is preferably a hydrocarbon radical such as a methyl group to reduce the silicon-bonded hydroxyl content of the adhesive and thereby its sensitivity to amino-functional drugs.

Abstract: This invention relates to an improved transdermal drug delivery device for the controlled transdermal delivery of amino-functional drugs. The improvement resides in providing the device with a silicone pressure-sensitive adhesive layer which has been chemically treated to reduce the silicon-bonded hydroxyl content of the pressure-sensitive adhesive composition to render the adhesive layer resistant to loss of tack and preserve the instant adherence of the device to the skin of a wearer during storage and while the device is being worn. Preferably, the composition used comprises a silicon-bonded hydroxyl radical containing resinous copolymer of R.sub.3 SiO.sub.1/2 units and SiO.sub.4/2 units and a polydiorganosiloxane which have been chemically treated with R.sub.3 SiO.sub.1/2 units where R is preferably a hydrocarbon radical such as a methyl group to reduce the silicon-bonded hydroxyl content of the adhesive and thereby its sensitivity to amino-functional drugs.