Patents by Inventor Virginia A. Birmingham

Virginia A. Birmingham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tylosin resistance-conferring gene, designated tlrC, for use in streptomyces fradiae
    Patent number: 4889809
    Abstract: The tlrC gene is a novel tylosin resistance-conferring gene isolated from Streptomyces fradiae and used to construct a number of cloning vectors for use in Streptomyces. One such cloning vector, plasmid pSKC10, can be obtained in S. fradiae JS87 under the accession number NRRL 18072. S. fradiae JS87 is the preferred host when the tlrC gene is used to select tylosin-resistant Streptomyces transformants.
    Type: Grant
    Filed: July 25, 1986
    Date of Patent: December 26, 1989
    Assignee: Eli Lilly and Company
    Inventors: Virginia A. Birmingham, Karen L. Cox, Eugene T. Seno
  • Tylosin resistance-conferring gene, designated tlrB, for use in streptomyces and other organisms
    Patent number: 4879241
    Abstract: The tlrB gene is a novel tylosin resistance-conferring gene isolated from Streptomyces fradiae and used to construct a number of cloning vectors for use in Streptomyces and related organisms. One such cloning vector, plasmid pSVB9, can be obtained in S. lividans under the accession number NRRL 18073. S. lividans is the preferred host when the tlrB gene is used to select tylosin-resistant Streptomyces transformants.
    Type: Grant
    Filed: June 5, 1986
    Date of Patent: November 7, 1989
    Assignee: Eli Lilly and Company
    Inventors: Virginia A. Birmingham, Eugene T. Seno
  • Method of selecting recombinant DNA-containing streptomyces
    Patent number: 4680265
    Abstract: A novel method of selecting Streptomyces recombinant DNA-containing host cells and vectors useful in the method are described. The vectors confer tylosin resistance to sensitive Streptomyces host cells and thus provide a convenient method of selecting Streptomyces transformants. The novel tylosin resistance-conferring gene described can be isolated on an .about.2.6 kb KpnI restriction fragment from plasmid pSVB2. Plasmid pSVB2 can be isolated from Streptomyces lividans TK23/pSVB2 (NRRL 15880).
    Type: Grant
    Filed: September 25, 1984
    Date of Patent: July 14, 1987
    Assignee: Eli Lilly and Company
    Inventors: Virginia A. Birmingham, Eugene T. Seno
  • Method of selecting recombinant DNA-containing streptomyces
    Patent number: RE34875
    Abstract: A novel method of selecting Streptomyces recombinant DNA-containing host cells and vectors useful in the method are described. The vectors confer tylosin resistance to sensitive Streptomyces host cells and thus provide a convenient method of selecting Streptomyces transformants. The novel tylosin resistance-conferring gene described can be isolated on an .about.2.6 kb KpnI restriction fragment from plasmid pSVB2. Plasmid pSVB2 can be isolated from Streptomyces lividans TK23/pSVB2 (NRRL 15880).
    Type: Grant
    Filed: December 2, 1992
    Date of Patent: March 14, 1995
    Assignee: Eli Lilly and Company
    Inventors: Virginia A. Birmingham, Eugene T. Seno