Abstract: A step platform for aerobic exercise may include multiple layers. The top layer may include an elastic foam member that is configured to at least partially deform when stepped on by a user. The middle layer may include a rigid support member that is configured to at least partially maintain the shape of the foam member. The foam member may include a cover that wraps around the foam member and at least a portion of the support member to fasten the support member to the foam member. The bottom layer may include a base member having a support ridge configured to at least partially restrict deformation of the foam member in at least one direction. The base member may be connectable to the support member.

Abstract: A step platform for aerobic exercise may include multiple layers. The top layer may include an elastic foam member that is configured to at least partially deform when stepped on by a user. The middle layer may include a rigid support member that is configured to at least partially maintain the shape of the foam member. The foam member may include a cover that wraps around the foam member and at least a portion of the support member to fasten the support member to the foam member. The bottom layer may include a base member having a support ridge configured to at least partially restrict deformation of the foam member in at least one direction. The base member may be connectable to the support member.

Abstract: A step platform for aerobic exercise may include multiple layers. The top layer may include an elastic foam member that is configured to at least partially deform when stepped on by a user. The middle layer may include a rigid support member that is configured to at least partially maintain the shape of the foam member. The foam member may include a cover that wraps around the foam member and at least a portion of the support member to fasten the support member to the foam member. The bottom layer may include a base member having a support ridge configured to at least partially restrict deformation of the foam member in at least one direction. The base member may be connectable to the support member.

Abstract: A step platform for aerobic exercise may include multiple layers. The top layer may include an elastic foam member that is configured to at least partially deform when stepped on by a user. The middle layer may include a rigid support member that is configured to at least partially maintain the shape of the foam member. The foam member may include a cover that wraps around the foam member and at least a portion of the support member to fasten the support member to the foam member. The bottom layer may include a base member having a support ridge configured to at least partially restrict deformation of the foam member in at least one direction. The base member may be connectable to the support member.

Abstract: A flow restrictor with a first disk having at least one inlet and at least one outlet and a flow path and a second disk having no flow path. The first disk and the second disk being stacked together. A mass flow controller comprising with an input, an output, a flow path, a pressure transducer and the above flow restrictor.

Abstract: A flow restrictor with a first disk having at least one inlet and at least one outlet and a flow path and a second disk having no flow path. The first disk and the second disk being stacked together. A mass flow controller comprising with an input, an output, a flow path, a pressure transducer and the above flow restrictor.

Abstract: The present invention relates to methods of treating pneumonic plague. More specifically, the present invention relates to methods of using plasmin or Pla inhibitors to treat pneumonic plague.

Abstract: A flow restrictor with a first disk having at least one inlet and at least one outlet and a flow path and a second disk having no flow path. The first disk and the second disk being stacked together. A mass flow controller comprising with an input, an output, a flow path, a pressure transducer and the above flow restrictor.

Abstract: A flow restrictor with a first disk having at least one inlet and at least one outlet and a flow path and a second disk having no flow path. The first disk and the second disk being stacked together. A mass flow controller comprising with an input, an output, a flow path, a pressure transducer and the above flow restrictor.

Abstract: Novel methods and microorganisms are provided, where novel genetic mammalian cell invasive capability is imparted to a microorganism by the introduction of an exogenous ail or hil gene. The resulting organisms are then capable of binding to mammalian cells and are transferred to the cytoplasm. Other novel genetic capabilities may be imparted to the unicellular microorganism, which may serve as a vaccine for one or more pathogens or may introduce genetic capabilities or foreign molecules into a mammalian host cell. The sequences may be used for an in vitro screen for pathogenicity. Mutant microorganisms having an attenuated invasive phenotype are also disclosed wherein one or more invasive genes have been modified.

Abstract: Novel methods and microorganisms are provided, where novel genetic mammalian cell invasive capability is imparted to a microorganism by the introduction of an exogenous inv gene. The resulting organisms are then capable of binding to mammalian cells and are transferred to the cytoplasm. Other novel genetic capabilities may be imparted to the unicellular microorganism, which may serve as a vaccine for one or more pathogens or may introduce genetic capabilities or foreign molecules into a mammalian host cell. The sequences may be used for an in vitro screen for pathogenicity.

Abstract: Novel methods and microorganisms are provided, where novel genetic mammalian cell invasive capability is imparted to a microorganism by the introduction of an exogenous inv or ail gene. The resulting organisms are then capable of binding to mammalian cells and are transferred to the cytoplasm. Other novel genetic capabilities may be imparted to the unicellular microorganism, which may serve as a vaccine for one or more pathogens or may introduce genetic capabilities or foreign molecules into a mammalian host cell. The sequences may be used for an in vitro screen for pathogenicity.

Abstract: Nucleic acids encoding all or part of a Yersinia ail gene are provided. The nucleic acid comprises at least 50 base pairs of a Yersinia ail gene in isolated form or consists or a fragment consisting essentially of at least 50 base pairs but not more than 50 kilo base pairs of a Yersinia ail gene. Such nucleic acids can also be operably linked to transcriptional and translational initiation and termination sequences which are functional in a microorganism host.