Abstract: The present invention relates to a modified-release composition of mazindol and its use in the treatment of attention deficit disorders (ADD) or attention deficit/hyperactivity disorder (ADHD) or related deficit of alertness (i.e., incoercible sleepiness) or decline of vigilance (i.e., daytime somnolence) or excessive daytime sleepiness (e.g., narcolepsy, idiopathic hypersomnia) in particular in children, adolescents and adults.

Abstract: The present invention relates to a modified-release composition of mazindol and its use in the treatment of attention deficit disorders (ADD) or attention deficit/hyperactivity disorder (ADHD) or related deficit of alertness (i.e., incoercible sleepiness) or decline of vigilance (i.e., daytime somnolence) or excessive daytime sleepiness (e.g., narcolepsy, idiopathic hypersomnia) in particular in children, adolescents and adults.

Abstract: The present invention relates to a modified-release composition of mazindol and its use in the treatment of attention deficit disorders (ADD) or attention deficit/hyperactivity disorder (ADHD) or related deficit of alertness (i.e., incoercible sleepiness) or decline of vigilance (i.e., daytime somnolence) or excessive daytime sleepiness (e.g., narcolepsy, idiopathic hypersomnia) in particular in children, adolescents and adults.

Abstract: The present invention is directed to methods of treating elderly patients with Alitretinoin severe chronic hand eczema (CHE), refractory to treatment with potent topical corticosteroids. One embodiment of the invention is a method of improving the efficacy of Alitretinoin treatment for Severe Refractory Chronic Hand Eczema (CHE) comprising a) identifying and/or selecting a patient in need of treatment, wherein the age of the patient is 50 years old or greater; b) administering an effective amount of Alitretinoin to said patient; c) determining PGA score; and d) discontinuing treatment with Alitretinoin when said patient achieves the PGA score of 1 or 2; thereby. The improvement is also expected to reduce risks in the patient population as continuing treatment will not be necessary.

Abstract: Methods of preventing and treating opioid bowel dysfunction are disclosed. In addition, methods of increasing the frequency of spontaneous complete bowel movements, methods for improving the quality of life of a patient suffering from opioid bowel dysfunction, methods for reducing a patient's dependence on laxatives, and methods for preventing or treating pain are also disclosed.