Patents by Inventor Virginie Nepote

Virginie Nepote has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diabetes model animal
    Patent number: 7642401
    Abstract: We prepared a transgene comprising human HB-EGF precursor cDNA, as a diphtheria toxin receptor gene, at the downstream of an insulin promoter, and introduced this transgene into a mouse fertilized egg, to produce a transgenic mouse of the present invention. In this mouse, human HB-EGF precursors are expressed specifically in islet beta cells, and by injection of diphtheria toxin, islet beta cells are selectively destroyed, resulting in that the mouse shows diabetes two or three days after the injection. This mouse can be utilized in screening and development of new medicines and therapy protocols for diabetes.
    Type: Grant
    Filed: August 1, 2005
    Date of Patent: January 5, 2010
    Assignees: National University Corporation Nara Institute of Science and Technology, University of Geneva
    Inventors: Kenji Kohno, Pedro Herrera, Virginie Nepote
  • Diabetes Model Animal
    Publication number: 20080320609
    Abstract: We prepared a transgene comprising human HB-EGF precursor cDNA, as a diphtheria toxin receptor gene, at the downstream of an insulin promoter, and introduced this transgene into a mouse fertilized egg, to produce a transgenic mouse of the present invention. In this mouse, human HB-EGF precursors are expressed specifically in islet beta cells, and by injection of diphtheria toxin, islet beta cells are selectively destroyed, resulting in that the mouse shows diabetes two or three days after the injection. This mouse can be utilized in screening and development of new medicines and therapy protocols for diabetes.
    Type: Application
    Filed: August 1, 2005
    Publication date: December 25, 2008
    Applicant: UNIVERSITY OF GENEVA
    Inventors: Kenji Kohno, Pedro Herrera, Virginie Nepote