Abstract: Managing tasks using an application-level blue-green topology with parallel cell infrastructure rails. Each cell infrastructure rail includes a dispatcher bot and a performer bot. The dispatcher bot is configured to prepare a work task based on a received request, and the performer bot performs the work task, resulting in performed work. A discovery server includes a service registry configured to store the states of the infrastructure rails. The discovery server receives the request for the work task, and sends the request to a dispatcher bot of a specific cell infrastructure rail based on the request and the states of the cell infrastructure rails. A respective workflow cell server receives the performed work. In the case that one cell infrastructure rail experiences a problem when processing the request, the cell infrastructure rails are switched to perform the request on the other cell infrastructure rail. The method implements the system.

Abstract: A method for monitoring and predicting batch activity in real time comprises obtaining i) ordered lists of jobs from scheduling platforms and ii) information related to jobs from one or more file transfer sources including real time event information, extracting data from the ordered lists of jobs and file transfer information, enriching the extracted data using additional information retrieved from at least one meta data repository, and generating a dependency graph that includes real time job and file transfer data obtained from the enriched data in which nodes of the graph represent events and edges represent relationships between the nodes indicating a dependence. Critical milestones are obtained from the dependency graph, critical paths for traversing the dependency graph for job and file transfer execution, and times for execution of each of the jobs and file transfers in the critical paths are predicted in real time.

Abstract: Managing tasks using an application-level blue-green topology with parallel cell infrastructure rails. Each cell infrastructure rail includes a dispatcher bot and a performer bot. The dispatcher bot is configured to prepare a work task based on a received request, and the performer bot performs the work task, resulting in performed work. A discovery server includes a service registry configured to store the states of the infrastructure rails. The discovery server receives the request for the work task, and sends the request to a dispatcher bot of a specific cell infrastructure rail based on the request and the states of the cell infrastructure rails. A respective workflow cell server receives the performed work. In the case that one cell infrastructure rail experiences a problem when processing the request, the cell infrastructure rails are switched to perform the request on the other cell infrastructure rail. The method implements the system.

Abstract: This disclosure features the use of one or more indazole-3-carboxamide compounds or salts or analogs thereof, in the treatment of one or more diseases or conditions independently selected from the group consisting of a tendinopathy, dermatitis, psoriasis, morphea, ichthyosis, Raynaud's syndrome, and Darier's disease; and/or for promoting wound healing. The methods include administering to a subject (e.g., a subject in need thereof) a therapeutically effective amount of one or more indazole-3-carboxamide compounds or salts or analogs thereof as described anywhere herein.

Abstract: Provided herein are methods of treating cartilage disorders in a subject using a dual CLK/DYRK inhibitor, or a pharmaceutically acceptable salt of solvate thereof, or a combination of a CLK inhibitor, or a pharmaceutically acceptable salt of solvate thereof, and DYRK inhibitor or, pharmaceutically acceptable salt or solvate thereof.

Abstract: The present invention provides methods of inducing differentiation of oligodendrocyte progenitor cells to a mature myelinating cell fate with a neurotransmitter receptor modulating agent. The present invention also provides methods of stimulating increased myelination in a subject in need thereof by administering said neurotransmitter receptor modulating agent. Methods of treating a subject having a demyelinating disease using a neurotransmitter receptor modulating agent are also provided.

Abstract: This disclosure features the use of one or more indazole-3-carboxamide compounds or salts or analogs thereof, in the treatment of one or more diseases or conditions independently selected from the group consisting of a tendinopathy, dermatitis, psoriasis, morphea, ichthyosis, Raynaud's syndrome, and Darier's disease; and/or for promoting wound healing. The methods include administering to a subject (e.g., a subject in need thereof) a therapeutically effective amount of one or more indazole-3-carboxamide compounds or salts or analogs thereof as described anywhere herein.

Abstract: The present invention provides methods of inducing differentiation of oligodendrocyte progenitor cells to a mature myelinating cell fate with a neurotransmitter receptor modulating agent. The present invention also provides methods of stimulating increased myelination in a subject in need thereof by administering said neurotransmitter receptor modulating agent. Methods of treating a subject having a demyelinating disease using a neurotransmitter receptor modulating agent are also provided.

Abstract: This disclosure features the use of one or more indazole-3-carboxamide compounds or salts or analogs thereof, in the treatment of one or more diseases or conditions independently selected from the group consisting of a tendinopathy, dermatitis, psoriasis, morphea, ichthyosis, Raynaud's syndrome, and Darier's disease; and/or for promoting wound healing. The methods include administering to a subject (e.g., a subject in need thereof) a therapeutically effective amount of one or more indazole-3-carboxamide compounds or salts or analogs thereof as described anywhere herein.

Abstract: The present invention provides methods of inducing differentiation of oligodendrocyte progenitor cells to a mature myelinating cell fate with a neurotransmitter receptor modulating agent. The present invention also provides methods of stimulating increased myelination in a subject in need thereof by administering said neurotransmitter receptor modulating agent. Methods of treating a subject having a demyelinating disease using a neurotransmitter receptor modulating agent are also provided.

Abstract: The present invention provides methods of inducing differentiation of oligodendrocyte progenitor cells to a mature myelinating cell fate with a neurotransmitter receptor modulating agent. The present invention also provides methods of stimulating increased myelination in a subject in need thereof by administering said neurotransmitter receptor modulating agent. Methods of treating a subject having a demyelinating disease using a neurotransmitter receptor modulating agent are also provided.

Abstract: This disclosure features the use of one or more indazole-3-carboxamide compounds or salts or analogs thereof, in the treatment of one or more diseases or conditions independently selected from the group consisting of a tendinopathy, dermatitis, psoriasis, morphea, ichthyosis, Raynaud's syndrome, and Darier's disease; and/or for promoting wound healing. The methods include administering to a subject (e.g., a subject in need thereof) a therapeutically effective amount of one or more indazole-3-carboxamide compounds or salts or analogs thereof as described anywhere herein.

Abstract: The present invention provides methods of inducing differentiation of oligodendrocyte progenitor cells to a mature myelinating cell fate with a neurotransmitter receptor modulating agent. The present invention also provides methods of stimulating increased myelination in a subject in need thereof by administering said neurotransmitter receptor modulating agent. Methods of treating a subject having a demyelinating disease using a neurotransmitter receptor modulating agent are also provided.

Abstract: The present invention provides methods of inducing differentiation of oligodendrocyte progenitor cells to a mature myelinating cell fate with a neurotransmitter receptor modulating agent. The present invention also provides methods of stimulating increased myelination in a subject in need thereof by administering said neurotransmitter receptor modulating agent. Methods of treating a subject having a demyelinating disease using a neurotransmitter receptor modulating agent are also provided.

Abstract: The present invention provides methods of inducing differentiation of oligodendrocyte progenitor cells to a mature myelinating cell fate with a neurotransmitter receptor modulating agent. The present invention also provides methods of stimulating increased myelination in a subject in need thereof by administering said neurotransmitter receptor modulating agent. Methods of treating a subject having a demyelinating disease using a neurotransmitter receptor modulating agent are also provided.

Abstract: The present invention provides methods of inducing differentiation of oligodendrocyte progenitor cells to a mature myelinating cell fate with a neurotransmitter receptor modulating agent. The present invention also provides methods of stimulating increased myelination in a subject in need thereof by administering said neurotransmitter receptor modulating agent. Methods of treating a subject having a demyelinating disease using a neurotransmitter receptor modulating agent are also provided.

Abstract: A troubleshooting tool for simplifying troubleshooting of errors in configurable parameter values associated with computer supported business-flows. The parameter values affecting the business-flows are stored in the tables of a database system in one embodiment. An administrator specifies the set of parameters which determine the specific row of the table that would be used by the business-flow, and the manner (e.g., as an SQL query) in which the specific row is determined. A user then invokes the tool, selects a specific business-flow (or parameter) to troubleshoot. The tool receives values for the set of parameters specified by the administrator and retrieves the specific data element representing the value of the parameter of interest (according to the SQL query). The retrieved data element can be compared with an expected value to troubleshoot the business-flow.