Abstract: The present disclosure relates to chimeric ABC transporter proteins and methods of screening for molecules that bind to the periplasmic, extracellular, and/or luminal face of an ABC transporter protein using the chimeric ABC transporters. For example, in some embodiments, screening methods involve providing a chimeric ABC transporter in which one or more regions of the periplasmic, extracellular, and/or luminal face of the ABC transporter are substituted with one or more equivalent regions of the periplasmic, extracellular, and/or luminal face of a different ABC transporter and selecting for molecules that bind to the ABC transporter but do not bind to the chimeric ABC transporter. The disclosure also relates to molecules that bind to the periplasmic, extracellular, and/or luminal face of an ABC transporter protein, for example, identified in such screens.

Abstract: Examples herein relate to polling for input/output transactions of a network interface or a storage device, or any peripheral device. Some examples monitor clock cycles spent checking for a presence of input/output (I/O) events and processing I/O events and monitor clock cycles spent checking for presence of I/O events without completing an I/O event. Central processing unit (CPU) core utilization can be based on clock cycles spent checking for a presence of I/O events and processing I/O events and clock cycles spent checking for presence of I/O events without completion of an I/O event. For example, if core utilization is below a threshold, frequency of the core can be reduced for performing polling of I/O events. If core utilization is at or above the threshold, frequency of the core can be increased used to performing polling of I/O events.

Abstract: This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof pharmaceutical compositions containing them, and to their use in therapy for the prevention treatment of cancer.

Abstract: This invention relates to a process for detecting and mitigating risk generated when a customer's log-in credentials are compromised. A significant majority of stolen credentials and customer's personally identifiable information data eventually make their way to the dark web. By dynamically monitoring the dark web and combining the analysis with related information about the user and their credentials on the deep web and the surface web, through a machine learning model, a service provider pre-emptively or otherwise can act to mitigate the risk arising from such compromise of said customer log-in credentials.

Abstract: The invention relates generally to pyrrolobenzodiazepine monomer and dimer prodrugs having a glutathione-activated disulfide prodrug moiety, a DT-diaphorase-activated quinone prodrug moiety or a reactive oxygen species-activated aryl boronic acid or aryl boronic ester prodrug moiety. The invention further relates to pyrrolobenzodiazepine prodrug dimer-antibody conjugates.

Abstract: A method and system for detecting an accident of a vehicle, the method including: receiving a movement dataset collected at least at one of a location sensor and a motion sensor arranged within the vehicle, during a time period of movement of the vehicle, extracting a set of movement features associated with at least one of a position, a velocity, and an acceleration characterizing the movement of the vehicle during the time period, detecting a vehicular accident event from processing the set of movement features with an accident detection model, and in response to detecting the vehicular accident event, automatically initiating an accident response action.

Abstract: A method and system for detecting an accident of a vehicle, the method including: receiving a movement dataset collected at least at one of a location sensor and a motion sensor arranged within the vehicle, during a time period of movement of the vehicle, extracting a set of movement features associated with at least one of a position, a velocity, and an acceleration characterizing the movement of the vehicle during the time period, detecting a vehicular accident event from processing the set of movement features with an accident detection model, and in response to detecting the vehicular accident event, automatically initiating an accident response action.

Abstract: A method for risk determination of a route includes collecting a set of inputs and determining a set of risk scores. Additionally, the method can include any or all of: processing the set of inputs; organizing the set of inputs; determining a model based on the set of inputs; determining a set of risk scores; producing an outputs based on the set of risk scores; and/or any other suitable processes.

Abstract: The invention is concerned with the compounds of formula I or II: and salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I or II as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

Abstract: This invention relates to a process for detecting and mitigating risk generated when a customer's log-in credentials are compromised. A significant majority of stolen credentials and customer's personally identifiable information data eventually make their way to the dark web. By dynamically monitoring the dark web and combining the analysis with related information about the user and their credentials on the deep web and the surface web, through a machine learning model, a service provider pre-emptively or otherwise can act to mitigate the risk arising from such compromise of said customer log-in credentials.

Abstract: A method for risk determination of a route includes collecting a set of inputs and determining a set of risk scores. Additionally, the method can include any or all of: processing the set of inputs; organizing the set of inputs; determining a model based on the set of inputs; determining a set of risk scores; producing an outputs based on the set of risk scores; and/or any other suitable processes.

Abstract: This invention relates to a process for detecting and mitigating risk generated when a customer's log-in credentials are compromised. A significant majority of stolen credentials and customer's personally identifiable information data eventually make their way to the dark web. By dynamically monitoring the dark web and combining the analysis with related information about the user and their credentials on the deep web and the surface web, through a machine learning model, a service provider pre-emptively or otherwise can act to mitigate the risk arising from such compromise of said customer log-in credentials.

Abstract: Disclosed herein are instruments and related methods for measuring oxidative potential (OP) in airborne particulates, particularly PM2.5. The instrument is formed from three main components: a sample injector, a sample incubator and a measurement system. The instrument provides an automatic measure of five OP endpoints in a relatively rapid time frame of less than 3 hours. In this manner, additional parameters beyond the gross particle concentration or mass per unit volume is obtained, including the biologically-relevant OP associated with PM2.5.

Abstract: Systems, apparatuses and methods may provide for technology that identifies a first set of compute nodes and a second set of compute nodes, wherein the first set of compute nodes execute more slowly than the second set of compute nodes. The technology may also automatically determine a compute node configuration that results in a relatively low difference in completion time between the first set of compute nodes and the second set of compute nodes with respect to a neural network workload. In an example, the technology applies the compute node configuration to an execution of the neural network workload on one or more nodes in the first set of compute nodes and one or more nodes in the second set of compute nodes.

Abstract: A method for risk determination of a route includes collecting a set of inputs and determining a set of risk scores. Additionally, the method can include any or all of: processing the set of inputs; organizing the set of inputs; determining a model based on the set of inputs; determining a set of risk scores; producing an outputs based on the set of risk scores; and/or any other suitable processes.

Abstract: A method and system for detecting an accident of a vehicle, the method including: receiving a movement dataset collected at least at one of a location sensor and a motion sensor arranged within the vehicle, during a time period of movement of the vehicle, extracting a set of movement features associated with at least one of a position, a velocity, and an acceleration characterizing the movement of the vehicle during the time period, detecting a vehicular accident event from processing the set of movement features with an accident detection model, and in response to detecting the vehicular accident event, automatically initiating an accident response action.

Abstract: A method and system for detecting an accident of a vehicle, the method including: receiving a movement dataset collected at least at one of a location sensor and a motion sensor arranged within the vehicle, during a time period of movement of the vehicle, extracting a set of movement features associated with at least one of a position, a velocity, and an acceleration characterizing the movement of the vehicle during the time period, detecting a vehicular accident event from processing the set of movement features with an accident detection model, and in response to detecting the vehicular accident event, automatically initiating an accident response action.

Abstract: The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

Abstract: Examples herein relate to polling for input/output transactions of a network interface or a storage device, or any peripheral device. Some examples monitor clock cycles spent checking for a presence of input/output (I/O) events and processing I/O events and monitor clock cycles spent checking for presence of I/O events without completing an I/O event. Central processing unit (CPU) core utilization can be based on clock cycles spent checking for a presence of I/O events and processing I/O events and clock cycles spent checking for presence of I/O events without completion of an I/O event. For example, if core utilization is below a threshold, frequency of the core can be reduced for performing polling of I/O events. If core utilization is at or above the threshold, frequency of the core can be increased used to performing polling of I/O events.

Abstract: The invention provides compounds of formula I: and pharmaceutically acceptable salts thereof where R1 is a substituted or unsubstituted phenyl or a fused bicyclic comprising a substituted or unsubstituted phenyl. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.