Patents by Inventor Vishnumurthy Kodumuru

Vishnumurthy Kodumuru has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ORGANIC COMPOUNDS
    Publication number: 20160289191
    Abstract: The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.
    Type: Application
    Filed: October 9, 2015
    Publication date: October 6, 2016
    Applicants: XENON PHARMACEUTICALS INC., NOVARTIS AG
    Inventors: Natalie Dales, Zaihui Zhang, Jianmin Fu, Duanjie Hou, Shaoyi Sun, Vishnumurthy Kodumuru, Natalia Pokrovskaia
  • Organic compounds
    Patent number: 9187426
    Abstract: The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.
    Type: Grant
    Filed: June 25, 2009
    Date of Patent: November 17, 2015
    Assignees: Novartis AG, Xenon Pharmaceuticals
    Inventors: Natalie Dales, Zaihui Zhang, Jianmin Fu, Duanjie Hou, Shaoyi Sun, Vishnumurthy Kodumuru, Natalia Pokrovskaia
  • ORGANIC COMPOUNDS
    Publication number: 20140024583
    Abstract: The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.
    Type: Application
    Filed: July 15, 2013
    Publication date: January 23, 2014
    Inventors: Natalie Dales, Julia Fonarev, Jianmin Fu, Duanjie Hou, Rajender Kamboj, Vishnumurthy Kodumuru, Natalia Pokrovskaia, Vandna Raina, Shaoyi Sun, Zaihui Zhang
  • Aminothiazole derivatives as human stearoyl-CoA desaturase inhibitors
    Patent number: 8541457
    Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I), where V, W, R1, R2, R3 and R4 are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
    Type: Grant
    Filed: June 5, 2006
    Date of Patent: September 24, 2013
    Assignee: Xenon Pharmaceuticals Inc.
    Inventors: Jianmin Fu, Duanjie Hou, Rajender Kamboj, Vishnumurthy Kodumuru, Natalia Pokrovskaia, Vandna Raina, Shaoyi Sun, Serguei Sviridov, Zaihui Zhang
  • Organic compounds
    Patent number: 8501746
    Abstract: The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.
    Type: Grant
    Filed: June 4, 2007
    Date of Patent: August 6, 2013
    Assignees: Xenon Pharmaceuticals Inc., Novartis AG
    Inventors: Natalie Dales, Julia Fonarev, Jianmin Fu, Duanjie Hou, Rajender Kamboj, Vishnumurthy Kodumuru, Natalia Pokrovskaia, Vandna Raina, Shaoyi Sun, Zaihui Zhang
  • AMINOTHIAZOLE DERIVATIVES AS HUMAN STEAROYL-COA DESATURASE INHIBITORS
    Publication number: 20130096056
    Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where V, W, R1, R2, R3 and R4 are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
    Type: Application
    Filed: September 14, 2012
    Publication date: April 18, 2013
    Applicant: XENON PHARMACEUTICALS INC.
    Inventors: Jianmin Fu, Duanjie Hou, Rajender Kamboj, Vishnumurthy Kodumuru, Natalia Pokrovskaia, Vandna Raina, Shaoyi Sun, Serguei Sviridov, Zaihui Zhang
  • PYRIDYL DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS
    Publication number: 20130079354
    Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein W, V, x, y, R1, R2, R3, R4, R5, R6, R7, R7a, R8, R8a, R9, R9a, R10 and R10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
    Type: Application
    Filed: September 14, 2012
    Publication date: March 28, 2013
    Applicant: Xenon Pharmaceuticals Inc.
    Inventors: Melwyn ABREO, Daniel F. HARVEY, Mikhail A. KONDRATENKO, Wenbao LI, Rajender KAMBOJ, Vishnumurthy KODUMURU, Michael D. WINTHER, Heinz W. GSCHWEND, Nagasree CHAKKA, Shifeng LIU, Serguei SVIRIDOV, Shaoyi SUN
  • Pyridyl derivatives and their use as therapeutic agents
    Patent number: 8383628
    Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein W, V, x, y, R1, R2, R3, R4, R5, R6, R7, R7a, R8, R8a, R9, R9a, R10 and R10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
    Type: Grant
    Filed: June 15, 2010
    Date of Patent: February 26, 2013
    Assignee: Xenon Pharmaceuticals Inc.
    Inventors: Melwyn Abreo, Daniel F. Harvey, Mikhail A. Kondratenko, Wenbao Li, Rajender Kamboj, Vishnumurthy Kodumuru, Michael D. Winther, Heinz W. Gschwend, Nagasree Chakka, Shifeng Liu, Serguei Sviridov, Shaoyi Sun
  • Organic compounds
    Patent number: 8318949
    Abstract: The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.
    Type: Grant
    Filed: September 21, 2011
    Date of Patent: November 27, 2012
    Assignee: Novartis AG
    Inventors: Sultan Chowdhury, Natalie Dales, Julia Fonarev, Jianmin Fu, Duanjie Hou, Qi Jia, Vishnumurthy Kodumuru, Natalia Pokrovskaia, Shaoyi Sun, Zaihui Zhang
  • Organic compounds
    Patent number: 8293768
    Abstract: The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.
    Type: Grant
    Filed: September 13, 2011
    Date of Patent: October 23, 2012
    Assignee: Novartis AG
    Inventors: Natalie Dales, Julia Fonarev, Jianmin Fu, Rajender Kamboj, Vishnumurthy Kodumuru, Shifeng Liu, Natalia Pokrovskaia, Vandna Raina, Shaoyi Sun, Zaihui Zhang
  • SCD1 inhibitors triazole and tetrazole compounds
    Patent number: 8258160
    Abstract: The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.
    Type: Grant
    Filed: December 19, 2007
    Date of Patent: September 4, 2012
    Assignee: Novartis AG
    Inventors: Natalie Dales, Zaihui Zhang, Julia Fonarev, Jianmin Fu, Rajender Kamboj, Vishnumurthy Kodumuru, Natalia Pokrovskaia, Shaoyi Sun
  • Pyridyl derivatives and their use as therapeutic agents
    Patent number: 8153636
    Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein x, y, W, V, R1, R2, R3, R4, R5, R6, R7, R7a, R8, R8a, R9, R9a, R10 and R10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
    Type: Grant
    Filed: September 2, 2009
    Date of Patent: April 10, 2012
    Assignee: Xenon Pharmaceuticals Inc.
    Inventors: Melwyn Abreo, Daniel F. Harvey, Heinz W. Gschwend, Wenbao Li, Chi Tu, Rajender Kamboj, Michael D. Winther, Vishnumurthy Kodumuru, Cindy J. Hudson, Mikhail A. Kondratenko, Shifeng Liu, Vandna Raina, Serguei Sviridov, Zaihui Zhang, Mehran Seid Bagherzadeh, Shaoyi Sun
  • Pyridazine derivatives and their use as inhibitors of stearoyl-CoA desaturase-1 activity in a mammal
    Patent number: 8148378
    Abstract: A method of treating an SCD-mediated disease or condition in a mammal, preferably a human, includes administering to a mammal a compound of formula (I): where x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 and R9a are defined herein. The SCD-mediated disease or condition may be selected from the group consisting of Type II diabetes, impaired glucose tolerance, insulin resistance, obesity, fatty liver, non-alcoholic steatohepatitis, dyslipidemia, metabolic syndrome, acne, cardiovascular disease, hypertriglyceridemia, inflammation, cancer, and any combination of these.
    Type: Grant
    Filed: February 20, 2009
    Date of Patent: April 3, 2012
    Assignee: Xenon Pharmaceuticals Inc.
    Inventors: Heinz W. Gschwend, Vishnumurthy Kodumuru, Shifeng Liu, Rajender Kamboj
  • ORGANIC COMPOUNDS
    Publication number: 20120014906
    Abstract: The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.
    Type: Application
    Filed: September 21, 2011
    Publication date: January 19, 2012
    Applicants: XENON PHARMACEUTICALS INC., NOVARTIS AG
    Inventors: Sultan Chowdhury, Natalie Dales, Julia Fonarev, Jianmin Fu, Duanjie Hou, Qi Jia, Vishnumurthy Kodumuru, Natalia Pokrovskaia, Shaoyi Sun, Zaihui Zhang
  • ORGANIC COMPOUNDS
    Publication number: 20120004164
    Abstract: The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.
    Type: Application
    Filed: September 13, 2011
    Publication date: January 5, 2012
    Applicants: NOVARTIS AG
    Inventors: Natalie Dales, Julia Fonarev, Jianmin Fu, Rajender Kamboj, Vishnumurthy Kodumuru, Shifeng Liu, Natalia Pokrovskaia, Vandna Raina, Shaoyi Sun, Zaihui Zhang
  • Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
    Patent number: 8071603
    Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I) where x, y, J, K, W, V, R3, R4, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
    Type: Grant
    Filed: September 20, 2005
    Date of Patent: December 6, 2011
    Assignee: Xenon Pharmaceuticals Inc.
    Inventors: Rajender Kamboj, Zaihui Zhang, Serguei Sviridov, Vandna Raina, Duanjie Hou, Vishnumurthy Kodumuru, Mehran Seid Bagherzadeh
  • Heterocyclic compounds suitable for the treatment of diseases related to elevated lipid levels
    Patent number: 8063084
    Abstract: The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.
    Type: Grant
    Filed: August 13, 2007
    Date of Patent: November 22, 2011
    Assignees: Novartis AG, Xenon Pharmaceuticals Inc.
    Inventors: Natalie Dales, Julia Fonarev, Jianmin Fu, Rajender Kamboj, Vishnumurthy Kodumuru, Shifeng Liu, Natalia Pokrovskaia, Vandna Raina, Shaoyi Sun, Zaihui Zhang
  • Thiazole derivatives which inhibit stearoyl-CoA desaturase enzymes
    Patent number: 8049016
    Abstract: The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.
    Type: Grant
    Filed: February 20, 2009
    Date of Patent: November 1, 2011
    Assignees: Novartis AG, Xenon Pharmaceuticals Inc
    Inventors: Sultan Chowdhury, Natalie Dales, Julia Fonarev, Jianmin Fu, Duanjie Hou, Qi Jia, Vishnumurthy Kodumuru, Natalia Pokrovskaia, Shaoyi Sun, Zaihui Zhang
  • Piperazine derivatives as stearoyl-coa desaturase inhibitors and their use as therapeutic agents
    Patent number: 8030488
    Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where G, J, L, M, x, y, W, V, R2, R3, R4, R5, R6, R7, R8, R8a, R9, R9a, R10, R10a, R11 and R11a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
    Type: Grant
    Filed: October 8, 2008
    Date of Patent: October 4, 2011
    Assignee: Xenon Pharmaceuticals Inc.
    Inventors: Serguei Sviridov, Vishnumurthy Kodumuru, Shifeng Liu, Melwyn Abreo, Michael D. Winther, Heinz W. Gschwend, Rajender Kamboj, Shaoyi Sun, Mark W. Holladay, Wenbao Li, Chi Tu
  • Substituted pyridazines as stearoyl-CoA desaturase inhibitors
    Patent number: 8026360
    Abstract: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, G, J, K, L, M, W, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
    Type: Grant
    Filed: August 13, 2009
    Date of Patent: September 27, 2011
    Assignee: Xenon Pharmaceuticals Inc.
    Inventors: Rajender Kamboj, Zaihui Zhang, Jianmin Fu, Vandna Raina, Serguei Sviridov, Vishnumurthy Kodumuru, Nagasree Chakka, Shifeng Lui, Shaoyi Sun, Duanjie Hou