Patents by Inventor Vishva Dixit

Vishva Dixit has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-polyubiquitin antibodies and methods of use
    Patent number: 8992919
    Abstract: The invention provides anti-polyubiquitin antibodies and methods of using the same.
    Type: Grant
    Filed: April 14, 2011
    Date of Patent: March 31, 2015
    Assignee: Genentech, Inc.
    Inventors: Vishva Dixit, Robert F. Kelley, Marissa L. Matsumoto
  • ANTI-POLYUBIQUITIN ANTIBODIES AND METHODS OF USE
    Publication number: 20130058955
    Abstract: The invention provides anti-polyubiquitin antibodies and methods of using the same.
    Type: Application
    Filed: August 6, 2012
    Publication date: March 7, 2013
    Applicant: GENENTECH, INC.
    Inventors: Robert F. Kelley, Vishva Dixit, Marissa L. Matsumoto
  • ANTI-POLYUBIQUITIN ANTIBODIES AND METHODS OF USE
    Publication number: 20110256133
    Abstract: The invention provides anti-polyubiquitin antibodies and methods of using the same.
    Type: Application
    Filed: April 14, 2011
    Publication date: October 20, 2011
    Applicant: GENENTECH, INC.
    Inventors: VISHVA DIXIT, ROBERT F. KELLEY, MARISSA L. MATSUMOTO
  • COPI MOLECULES AND USES THEREOF
    Publication number: 20110045474
    Abstract: The invention provides diagnostic, prognostic, and therapeutic uses for detecting COP1 overexpression in a variety of cancers. The methods and uses can further include detecting p53 expression. The invention also provides reagents and kits for use in screening for test compounds that interfere with COP1 and p53 binding.
    Type: Application
    Filed: June 29, 2010
    Publication date: February 24, 2011
    Inventors: David Dornan, Dorothy French, Vishva Dixit
  • COP1 molecules and uses thereof
    Patent number: 7785815
    Abstract: The invention provides diagnostic, prognostic, and therapeutic uses for detecting COP1 overexpression in a variety of cancers. The methods and uses can further include detecting p53 expression. The invention also provides reagents and kits for use in screening for test compounds that interfere with COP1 and p53 binding.
    Type: Grant
    Filed: April 10, 2007
    Date of Patent: August 31, 2010
    Assignee: Genentech, Inc.
    Inventors: David Dornan, Dorothy French, Vishva Dixit
  • Methods for making recombinant proteins using apoptosis inhibitors
    Publication number: 20100087624
    Abstract: The invention provided improved methods of making and producing recombinant proteins in in vitro cultures of host cells using apoptosis inhibitors. The use of one or more apoptosis inhibitors in the methods can reduce apoptosis in the cell cultures and markedly improve yield of the desired recombinant proteins.
    Type: Application
    Filed: November 30, 2009
    Publication date: April 8, 2010
    Inventors: Vishva Dixit, Robert W. Hamilton, Jana van de Van de Goor
  • METHODS AND COMPOSITIONS FOR TARGETING RELT
    Publication number: 20080057066
    Abstract: Anti-RELT monoclonal antibodies, and methods for using the antibodies, are provided. Methods of using RELT polypeptides and nucleic acids in modulating immune cell development and in modulating cytokine production are also provided.
    Type: Application
    Filed: February 12, 2007
    Publication date: March 6, 2008
    Inventors: Vishva Dixit, Nobuhiko Kayagaki, Yan Wu
  • COP1 molecules and uses thereof
    Publication number: 20080009458
    Abstract: The invention provides diagnostic, prognostic, and therapeutic uses for detecting COP1 overexpression in a variety of cancers. The methods and uses can further include detecting p53 expression. The invention also provides reagents and kits for use in screening for test compounds that interfere with COP1 and p53 binding.
    Type: Application
    Filed: April 10, 2007
    Publication date: January 10, 2008
    Inventors: David Dornan, Dorothy French, Vishva Dixit
  • Methods for making recombinant proteins using apoptosis inhibitors
    Publication number: 20070004009
    Abstract: The invention provided improved methods of making and producing recombinant proteins in in vitro cultures of host cells using apoptosis inhibitors. The use of one or more apoptosis inhibitors in the methods can reduce apoptosis in the cell cultures and markedly improve yield of the desired recombinant proteins.
    Type: Application
    Filed: June 15, 2006
    Publication date: January 4, 2007
    Inventors: Vishva Dixit, Robert Hamilton, Jana van de Goor
  • I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1 and CD-95 induced apoptosis
    Publication number: 20060240036
    Abstract: The present invention relates to a novel I-FLICE-1 or I-FLICE-2 protein which is a novel inhibitor of TNFR-1 and CD-95 induced apoptosis. In particular, isolated nucleic acid molecules are provided encoding the human I-FLICE-1 or I-FLICE-2 protein. I-FLICE-1 or I-FLICE-2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of I-FLICE-1 or I-FLICE-2 activity. Also provided are therapeutic methods for treating diseases and disorders associated with apoptosis.
    Type: Application
    Filed: June 2, 2006
    Publication date: October 26, 2006
    Applicants: Human Genome Sciences, Inc., The Regents of the University of Michigan
    Inventors: Jian Ni, Craig Rosen, Vishva Dixit, Reiner Gentz, Joseph Kenny
  • Death domain containing receptor 4
    Publication number: 20050244857
    Abstract: The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity and methods for using DR4 polynucleotides and polypeptides. The invention also relates to the treatment of diseases associated with reduced or increased levels of apoptosis using antibodies specific for DR4, which may be agonists and/or antagonists of DR4 activity.
    Type: Application
    Filed: March 10, 2005
    Publication date: November 3, 2005
    Inventors: Jian Ni, Craig Rosen, James Pan, Reiner Gentz, Vishva Dixit
  • Death domain containing receptors
    Patent number: 6951735
    Abstract: The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.
    Type: Grant
    Filed: May 19, 1999
    Date of Patent: October 4, 2005
    Assignees: Human Genome Sciences, Inc., The Regents of the University of Michigan
    Inventors: Guo-Liang Yu, Jian Ni, Vishva Dixit, Reiner L. Gentz, Patrick J. Dillon
  • Interleukin-1 beta converting enzyme like apoptotic protease 6
    Publication number: 20050089984
    Abstract: Human ICE LAP-6 polypeptides and DNA (RNA) encoding such ICE LAP-6 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such ICE LAP-6 for the treatment of a susceptibility to viral infection, tumorogenesis and to diseases and defects in the control embryogenesis and tissue homeostasis, and the nucleic acid sequences described above may be employed in an assay for ascertaining such susceptibility.
    Type: Application
    Filed: October 12, 2004
    Publication date: April 28, 2005
    Inventors: Vishva Dixit, Wei-Wu He, Kristine Kikly, Steven Ruben
  • Taci and br3 polypeptides and uses thereof
    Publication number: 20050070689
    Abstract: Novel, receptors, referred to herein as “TACIs” and “BR3”, agonists and antagonists thereof, and method of using TACIs and BR3, as well as agonists and antagonists thereof, to modulate, for example, activity of tumor necrosis factor (TNF) and TNFR-related molecules, including members of the TNF and TNFR families referred to as TALL-1, APRIL, TACI, and BCMA, are provided. Methods for in vitro, in situ, and/or in vivo diagnosis and/or treatment of mammalian cells or pathological conditions associated with such TNF and TNFR-related molecules are further provided.
    Type: Application
    Filed: July 24, 2002
    Publication date: March 31, 2005
    Applicant: GENENTECH, INC.
    Inventors: Vishva Dixit, Iqbal Grewal, John Ridgway, Minhong Yan
  • Methods for making recombinant proteins using apoptosis inhibitors
    Publication number: 20040002139
    Abstract: The invention provided improved methods of making and producing recombinant proteins in in vitro cultures of host cells using apoptosis inhibitors. The use of one or more apoptosis inhibitors in the methods can reduce apoptosis in the cell cultures and markedly improve yield of the desired recombinant proteins.
    Type: Application
    Filed: June 27, 2003
    Publication date: January 1, 2004
    Applicant: Genentech, Inc.
    Inventors: Vishva Dixit, Robert W. Hamilton, Jana van de Goor
  • Methods for making recombinant proteins using apoptosis inhibitors
    Patent number: 6586206
    Abstract: The invention provided improved methods of making and producing recombinant proteins in in vitro cultures of host cells using apoptosis inhibitors. The use of one or more apoptosis inhibitors in the methods can reduce apoptosis in the cell cultures and markedly improve yield of the desired recombinant proteins.
    Type: Grant
    Filed: September 25, 2000
    Date of Patent: July 1, 2003
    Assignee: Genentech, Inc.
    Inventors: Vishva Dixit, Robert W. Hamilton, Jana van de Goor
  • DEATH DOMAIN CONTAINING RECEPTORS
    Publication number: 20030077694
    Abstract: The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.
    Type: Application
    Filed: May 19, 1999
    Publication date: April 24, 2003
    Inventors: GUO-LIANG YU, JIAN NI, VISHVA DIXIT, REINER L. GENTZ, PATRICK J. DILLON