Patents by Inventor Vishva M. Dixit

Vishva M. Dixit has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method and composition for regulating apoptosis
    Patent number: 6015665
    Abstract: Methods and compositions for preventing or inhibiting apoptosis are provided by this invention. The methods require introducing into a cell which may undergo apoptosis a nucleic acid molecule coding for a gene product having crmA biological activity or a crmA polypeptide. This invention also provides compositions and methods for maintaining T cell viability in a subject infected with the human immunodeficiency virus (HIV), by administering to the subject an effective amount of a nucleic acid molecule coding for a gene product having crmA biological activity or the gene product itself.
    Type: Grant
    Filed: February 13, 1995
    Date of Patent: January 18, 2000
    Assignee: The Regents of the University of Michigan
    Inventor: Vishva M. Dixit
  • Interleukin-1 .beta. converting enzyme like apoptotic protease-6
    Patent number: 6010878
    Abstract: Human ICE LAP-6 polypeptides and DNA (RNA) encoding such ICE LAP-6 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such ICE LAP-6 for the treatment of a susceptibility to viral infection, tumorogenesis and to diseases and defects in the control embryogenesis and tissue homeostasis, and the nucleic acid sequences described above may be employed in an assay for ascertaining such susceptibility.
    Type: Grant
    Filed: May 8, 1997
    Date of Patent: January 4, 2000
    Assignee: Smithkline Beecham Corporation
    Inventors: Vishva M. Dixit, Wei-Wu He, Kristine K. Kikly, Steven M. Ruben
  • Interleukin-1 beta converting enzyme like apoptotic protease-7
    Patent number: 6008042
    Abstract: Human ICE LAP-7 polypeptides and DNA (RNA) encoding such ICE LAP-7 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such ICE LAP-7 for the treatment of a susceptibility to viral infection, tumorogenesis and to diseases and defects in the control embryogenesis and tissue homeostasis, and the nucleic acid sequences described above may be employed in an assay for ascertaining such susceptibility.
    Type: Grant
    Filed: May 7, 1997
    Date of Patent: December 28, 1999
    Assignees: Smithkline Beecham Corporation, The Regents of the University of Michigan, Human Genome Sciences, Inc.
    Inventors: Vishva M. Dixit, Kristine K. Kikly, Steven M. Ruben, Jian Ni, Craig A. Rosen
  • Human IRAK-2
    Patent number: 5965421
    Abstract: The present invention relates to a novel IRAK-2 protein which is a member of the IL-1 signaling pathway. In particular, isolated nucleic acid molecules are provided encoding the human IRAK-2 protein. IRAK-2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic methods for detecting IRAK-2 related disorders and therapeutic methods for treating IRAK-2 related disorders.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: October 12, 1999
    Assignees: Human Genome Sciences, Inc., The Regents of the University of Michigan
    Inventors: Jian Ni, Ping Feng, Marta Muzio, Vishva M. Dixit
  • Cytokine-induced marker for inflammatory response
    Patent number: 5688656
    Abstract: A gene and its gene product which is a marker for inflammatory response have been identified, cloned and sequenced. With the identification of the B61 gene and its product, protein assays of biological fluids as well as nucleic acid probes and antibodies raised to the gene product can be used in a variety of hybridization and immunological assays to detect an impending inflammatory response. Such detection will enable earlier administration of appropriate therapy in immune response diseases.
    Type: Grant
    Filed: May 15, 1995
    Date of Patent: November 18, 1997
    Assignee: The Regents of the University of Michigan
    Inventor: Vishva M. Dixit
  • Cytokine-induced marker for inflammatory response
    Patent number: 5599669
    Abstract: A gene and its gene product which is a marker for inflammatory response have been identified, cloned and sequenced. With the identification of the B61 gene and its product, protein assays of biological fluids as well as nucleic acid probes and antibodies raised to the gene product can be used in a variety of hybridization and immunological assays to detect an impending inflammatory response. Such detection will enable earlier administration of appropriate therapy in immune response diseases.
    Type: Grant
    Filed: October 11, 1994
    Date of Patent: February 4, 1997
    Assignee: The Regents of the University of Michigan
    Inventor: Vishva M. Dixit