Abstract: A method of tuning a wearable device for collecting physiological data of a wearer, a wearable device for collecting physiological data of a wearer, a method of controlling a wearable device for collecting physiological data of a wearer, a wearable device for collecting physiological data of a wearer the method, and a computer-readable medium. The method of tuning a wearable device for collecting physiological data of a wearer comprises the steps of collecting a PPG signal using the device; determining whether or not the collected PPG signal is attributable to the wearer being human or animal; and discontinuing the tuning if the collected PPG signal is not attributable to the wearer being human or animal; wherein determining whether or not the collected PPG signal is attributable to the wearer being human or animal comprises determining information about at least one cardiac cycle based on at least one pulse in PPG signal.

Abstract: Disclosed is a photoplethysmography (PPG) apparatus (100) for determining physiological changes, comprising: a light source to emit alight signal having a variable intensity dependent on a skin characteristic; first and second photodetectors (130) operable to detect a reflection of the light signal to provide a combined current signal; and a signal processing circuit operable to convert the current signal into a PPG signal for determining the physiological changes.

Abstract: The present disclosure generally relates to a measurement device (110) and a method (200/300) for stress assessment of a user. The measurement device (110) comprises: a sensor module for measuring a number of sets of physiological data, each set of measured during a time period; a database (112) for storing the data; a display module (116) for displaying visual information (400/420/440).

Abstract: A method of sleep stage detection using vital sign features derived from PPG signals. The method includes performing a logistic regression operation based on a machine learning classifier model to calculate an indication value for an intermediate epoch. The indication value is calculated based on the vital sign features for the intermediate epoch as well as those of the preceding and succeeding epochs. The method then detects the sleep stage of the corresponding intermediate epoch based on the indication value for the corresponding intermediate epoch.

Abstract: A method of sleep stage detection using vital sign features derived from PPG signals. The method includes performing a logistic regression operation based on a machine learning classifier model to calculate an indication value for an intermediate epoch. The indication value is calculated based on the vital sign features for the intermediate epoch as well as those of the preceding and succeeding epochs. The method then detects the sleep stage of the corresponding intermediate epoch based on the indication value for the corresponding intermediate epoch.

Abstract: A method (200) of deriving systolic blood pressure and/or diastolic blood pressure of a subject is disclosed. The method comprises: (i) receiving (202) data related to at least one cardiac cycle of a bio-signal from the subject; (ii) calculating (208) a rise time and a fall time of the at least one cardiac cycle based on the received data; (iii) calculating (208) a parameter derived from a function of the rise time and fail time; and (iv) determining (210) the systolic blood pressure and/or diastolic blood pressure of the subject based on the calculated parameter. A related apparatus is also disclosed.

Abstract: An apparatus for assaying biofluid includes a receptacle for removably housing a set of cuvettes of a biofluid sample dispensing apparatus, each cuvette of the set of cuvettes containing an assay sample having a reagent and a sample of the biofluid; a receptacle sealing element disposed around the receptacle for providing sealing engagement between the receptacle and the biofluid sample dispensing apparatus for sealing the set of cuvettes within the receptacle; a vacuum source for evacuating the receptacle; and an automated assay system connected to the receptacle for performing an assay process on the assay samples in the set of cuvettes, while maintaining the set of cuvettes within the receptacle.

Abstract: A system for assaying biofluid samples including an assay apparatus and a dispensing apparatus. The dispensing apparatus includes cuvettes that contain reagents and the biofluid samples to form assay samples, and the assay apparatus has a receptable for receiving and sealing the cuvettes inside. Once the cuvettes are sealed in the receptable, the assay apparatus performs assay processes on the assay samples in the cuvettes.

Abstract: The present disclosure generally relates to a physiological device (100) for an animal The physiological device (100) comprises: a housing (120) comprising a channel (122) therethrough; an attachment layer (140) disposed on the housing (120) for attaching the physiological device (100) to an integument portion (50) of the animal; and a sensor unit (160) comprising a set of physiological sensors (162) for measuring physiological signals from the animal integument portion (50), the sensor unit (160) engageable with the channel (122) for axial displacement within the channel (122), wherein when the device (100) is attached to the animal integument portion (50), the sensor unit (160) is axially displaceable within the channel (122) for adjusting contact with the animal integument portion (50) for measuring the physiological signals.

Abstract: A method and related apparatus for deriving mean arterial pressure of a subject, including receiving data relating to at least one cardiac cycle of a bio-signal from the subject; normalizing the received data relating to the at least one cardiac cycle; calculating an area enclosed by the normalized received data to obtain a normalized area; calculating a heart rate of the subject from the at least one cardiac cycle; and deriving the mean arterial pressure from the normalized area and heart rate.

Abstract: A method (1500) for deriving a mental state of a subject is disclosed. The method comprises receiving (1502) a bio-signal from the subject; calculating respective statistical variations of at least two physiological parameters derived from the bio-signal; determining (1504) an arousal level of the subject based on the calculated statistical variations of the at least two physiological parameters; deriving a time-domain heart rate variability signal from the bio-signal for calculating at least two heart rate variability parameters; determining (1506) a valence level of the subject based on the at least two heart rate variability parameters; and deriving (1508) the mental state from the arousal level and valence level. A related apparatus is also disclosed.

Abstract: A method (1500) for deriving a mental state of a subject is disclosed. The method comprises receiving (1502) a bio-signal from the subject; calculating respective statistical variations of at least two physiological parameters derived from the bio-signal; determining (1504) an arousal level of the subject based on the calculated statistical variations of the at least two physiological parameters; deriving a time-domain heart rate variability signal from the bio-signal for calculating at least two heart rate variability parameters; determining (1506) a valence level of the subject based on the at least two heart rate variability parameters; and deriving (1508) the mental state from the arousal level and valence level. A related apparatus is also disclosed.

Abstract: In a described embodiment, a method of sleep stage detection is disclosed. The method comprises receiving a first vital sign feature 701a including a plurality of first feature values v1-v11 corresponding to respective ones of a plurality of epochs; and performing a first logistic regression operation 701a? to calculate a first indication value 702a for each intermediate one of the epochs based on the corresponding first feature value v6 and those of preceding v1-v5 and succeeding v7-v11 ones of the epochs, the first indication value 702a being descriptive of a sleep stage of the corresponding intermediate epoch. A method of creating a model for logistic regression, a method of extracting a heart rate variability feature, a method of creating a model for extracting a heart rate variability feature, a method of deriving a medical dosage, a method of assessing a responsiveness to a medical dosage, a computer-readable medium, a computing device and a wearable device are also disclosed.

Abstract: The present disclosure generally relates to a measurement device (110) and a method (200/300) for stress assessment of a user. The measurement device (110) comprises: a sensor module for measuring a number of sets of physiological data, each set of measured during a time period; a database (112) for storing the data; a display module (116) for displaying visual information (400/420/440).

Abstract: Disclosed is a photoplethysmography (PPG) apparatus (100) for determining physiological changes, comprising: a light source to emit alight signal having a variable intensity dependent on a skin characteristic; first and second photodetectors (130) operable to detect a reflection of the light signal to provide a combined current signal; and a signal processing circuit operable to convert the current signal into a PPG signal for determining the physiological changes.

Abstract: The present disclosure relates to apparatus for dispensing or assaying biofluid samples as well as a system for dispensing and assaying biofluid. One embodiment of the biofluid sample dispensing apparatus comprises a set of reservoirs and cavities, each reservoir comprising an inlet for receiving biofluid, an outlet in fluid communication with the inlet, a peripheral barrier surrounding the outlet for containing the biofluid sample within a cavity residing within said reservoir, a valve disposed at the outlet for releasably sealing the biofluid sample, as well as an overflow outlet to limit the predetermined volume of biofluid sample. An apparatus for assaying biofluid comprises a receptacle for housing cuvettes, a receptacle sealing element for sealing engagement between the receptacle and a biofluid sample dispensing apparatus for sealing the cuvettes and an automated system connected to receptacle for performing an assay process.

Abstract: A method (200) of deriving systolic blood pressure and/or diastolic blood pressure of a subject is disclosed. The method comprises: (i) receiving (202) data related to at least one cardiac cycle of a bio-signal from the subject; (ii) calculating (208) a rise time and a fall time of the at least one cardiac cycle based on the received data; (iii) calculating (208) a parameter derived from a function of the rise time and fail time; and (iv) determining (210) the systolic blood pressure and/or diastolic blood pressure of the subject based on the calculated parameter. A related apparatus is also disclosed.

Abstract: A method of deriving mean arterial pressure of a subject is disclosed. The method comprises (i) receiving (202) data relating to at least one cardiac cycle of a bio-signal from the subject; (ii) normalizing the received data relating to the at least one cardiac cycle; (iii) calculating (206) an area enclosed by the normalized received data to obtain a normalized area; (iv) calculating (208) a heart rate of the subject from the at least one cardiac cycle; and (v) deriving (210) the mean arterial pressure from the normalized area and heart rate. A related apparatus is also disclosed.

Abstract: A method (1500) for deriving a mental state of a subject is disclosed. The method comprises receiving (1502) a bio-signal from the subject; calculating respective statistical variations of at least two physiological parameters derived from the bio-signal; determining (1504) an arousal level of the subject based on the calculated statistical variations of the at least two physiological parameters; deriving a time-domain heart rate variability signal from the bio-signal for calculating at least two heart rate variability parameters; determining (1506) a valence level of the subject based on the at least two heart rate variability parameters; and deriving (1508) the mental state from the arousal level and valence level. A related apparatus is also disclosed.

Abstract: A reflectance-based optical measurement device and a method for a reflectance-based optical measurement are provided. The device comprises an illumination and detection assembly configured to output light to a surface portion of a user for measurement and to detect the output light reflected from said surface portion of the user as a signal; a coupling member configured for coupling in a cableless configuration to a personal mobile processing device; a measurement surface configured to allow access to said measurement surface by the surface portion of the user; wherein said access is provided by the optical device being holderless such that the surface portion of the user is allowed access to said measurement surface from all directions in a single plane; and further wherein said coupling member is arranged to transmit the detected signal to the personal mobile processing device.