Abstract: Model-based image reconstruction (MBIR) methods using convolutional neural networks (CNNs) as priors have demonstrated superior image quality and robustness compared to conventional methods. Studies have explored MBIR combined with supervised and unsupervised denoising techniques for image reconstruction in magnetic resonance imaging (MRI) and positron emission tomography (PET). Unsupervised methods like the deep image prior (DIP) have shown promising results and are less prone to hallucinations. However, since the noisy image is used as a reference, strategies to prevent overfitting are unclear. Recently, Bayesian DIP (BDIP) networks that model uncertainty tend to prevent overfitting without requiring early stopping. However, BDIP has not been studied with data-fidelity term for image reconstruction. Present disclosure provides systems and method that implement a MBIR framework with a modified BDIP.

Abstract: State of the art mechanisms being used for achieving diagnostic-quality images under low-dose settings for general CT imaging have the disadvantages that CT images are fixed during the optimization process to generate perfusion maps, which can lead to suboptimal CT images with respect to the perfusion maps generated, although they might appear spatially smooth or denoised. The disclosure herein generally relates to Computer Tomography (CT) scanning, and, more particularly, to a method and system for CT image reconstruction. The system performs modelling an optimization problem for joint estimation of a set of structural CT images and a perfusion map, and further solves the optimization problem for the reconstruction of the CT images of a subject.

Abstract: State of the art systems being used for QSM reconstruction have explored prior information from both magnitude and phase data. However, the underlying assumption is that the susceptibility maps and the magnitude images have coinciding edges. Establishing the ground-truth susceptibility maps is difficult and leads to limited applicability of supervised methods. Further, with portable MRI machines becoming a reality, low-field imaging is getting more prominence, which brings in several associated challenges due to noise and external interference. The disclosure herein generally relates to magnetic resonance imaging (MRI) imaging systems, and, more particularly, to a method and system for quantitative susceptibility mapping (QSM) reconstruction in magnetic resonance imaging (MRI) systems. The system performs an iterative reconstruction of QSM, wherein in each iteration the reconstructed QSM from previous iteration is refined by comparing with a reference image generated using same subject's prior MRI data.