Patents by Inventor Vit Lellek
Vit Lellek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11739103Abstract: The present disclosure provides processes for preparing a crystalline form of 3-((1R,3s,5S)-3-((7-((5-methyl-1H-pyrazol-3-yl)amino)-1,6-naphthyridin-5-yl)amino)-8-azabicyclo[3.2.1]octan-8-yl)propanenitrile and related intermediate compounds.Type: GrantFiled: October 7, 2021Date of Patent: August 29, 2023Assignee: Theravance Biopharma R&D LP, LLCInventors: Norbert Kraut, Matteo Conza, Anja Huste, Vit Lellek, Bjorn Gielen, Christian Pater, Dimitar Filipov, Xiaojun Huang, Stephen Roseblade
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Publication number: 20220112219Abstract: The present disclosure provides processes for preparing a crystalline form of 3-((1R,3s,5S)-3-((7-((5-methyl-1H-pyrazol-3-yl)amino)-1,6-naphthyridin-5-yl)amino)-8-azabicyclo[3.2.1]octan-8-yl)propanenitrile and related intermediate compounds.Type: ApplicationFiled: October 7, 2021Publication date: April 14, 2022Inventors: Norbert Kraut, Matteo Conza, Anja Huste, Vit Lellek, Bjorn Gielen, Christian Pater, Dimitar Filipov, Xiaojun Huang, Stephen Roseblade
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Patent number: 10323002Abstract: The present invention is directed to novel processes for the preparation of histamine H3 receptor modulators, in the treatment of for example, cognitive disorders, sleep disorders and/or psychiatric disorders.Type: GrantFiled: October 4, 2017Date of Patent: June 18, 2019Assignee: Janssen Pharmaceutica NVInventors: Diego Fernando Domenico Broggini, Vit Lellek, Susanne Lochner, Neelakandha S. Mani, Adrian Maurer, Daniel J. Pippel, Lana K. Young
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Publication number: 20180022704Abstract: The present invention is directed to novel processes for the preparation of histamine H3 receptor modulators, in the treatment of for example, cognitive disorders, sleep disorders and/or psychiatric disorders.Type: ApplicationFiled: October 4, 2017Publication date: January 25, 2018Applicant: Janssen Pharmaceutica NVInventors: Diego Fernando Domenico BROGGINI, Vit LELLEK, Susanne LOCHNER, Neelakandha S. MANI, Adrian MAURER, Daniel J. PIPPEL, Lana K. YOUNG
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Patent number: 9809547Abstract: The present invention is directed to novel processes for the preparation of histamine H3 receptor modulators, in the treatment of for example, cognitive disorders, sleep disorders and/or psychiatric disorders.Type: GrantFiled: November 11, 2016Date of Patent: November 7, 2017Assignee: Janssen Pharmaceutica NVInventors: Diego Fernando Domenico Broggini, Vit Lellek, Susanne Lochner, Neelakandha S. Mani, Adrian Maurer, Daniel J. Pippel, Lana K. Young
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Patent number: 9701688Abstract: The present invention is directed to a process for the preparation of opioid compounds such as buprenorphine, naltrexone, naloxone, nalbuphone, nalbuphine, and the like.Type: GrantFiled: April 17, 2015Date of Patent: July 11, 2017Assignee: NORAMCO, INC.Inventors: Matteo Conza, Vit Lellek, Hartmut Zinser
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Publication number: 20170057919Abstract: The present invention is directed to novel processes for the preparation of histamine H3 receptor modulators, in the treatment of for example, cognitive disorders, sleep disorders and/or psychiatric disorders.Type: ApplicationFiled: November 11, 2016Publication date: March 2, 2017Applicant: Janssen Pharmaceutica NVInventors: Diego Fernando Domenico BROGGINI, Vit LELLEK, Susanne LOCHNER, Neelakandha S. MANI, Adrian MAURER, Daniel J. PIPPEL, Lana K. YOUNG
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Patent number: 9518021Abstract: The present invention is directed to novel processes for the preparation of histamine H3 receptor modulators, in the treatment of for example, cognitive disorders, sleep disorders and/or psychiatric disorders.Type: GrantFiled: April 25, 2014Date of Patent: December 13, 2016Assignee: JANSSEN PHARMACEUTICA NVInventors: Diego Broggini, Vit Lellek, Susanne Lochner, Neelakandha S. Mani, Adrian Maurer, Daniel J. Pippel, Lana K. Young
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Publication number: 20150315205Abstract: The present invention is directed to a process for the preparation of opioid compounds such as buprenorphine, naltrexone, naloxone, nalbuphone, nalbuphine, and the like.Type: ApplicationFiled: April 17, 2015Publication date: November 5, 2015Inventors: Matteo Conza, Vit Lellek, Hartmut Zinser
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Publication number: 20140343279Abstract: The present invention is directed to novel processes for the preparation of histamine H3 receptor modulators, in the treatment of for example, cognitive disorders, sleep disorders and/or psychiatric disorders.Type: ApplicationFiled: April 25, 2014Publication date: November 20, 2014Applicant: Janssen Pharmaceutica NVInventors: Diego Broggini, Vit Lellek, Susanne Lochner, Neelakandha S. Mani, Adrian Maurer, Daniel J. Pippel, Lana K. Young
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Patent number: 8748596Abstract: The present invention is directed to novel processes for the preparation of histamine H3 receptor modulators, in the treatment of for example, cognitive disorders, sleep disorders and/or psychiatric disorders.Type: GrantFiled: March 17, 2010Date of Patent: June 10, 2014Assignee: Janssen Pharmaceutica NVInventors: Diego Broggini, Vit Lellek, Susanne Lochner, Neelakandha S. Mani, Adrian Maurer, Daniel J. Pippel, Lana K. Young
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Publication number: 20120029189Abstract: The present invention is directed to novel processes for the preparation of histamine H3 receptor modulators, in the treatment of for example, cognitive disorders, sleep disorders and/or psychiatric disorders.Type: ApplicationFiled: March 17, 2010Publication date: February 2, 2012Inventors: Diego Broggini, Vit Lellek, Susanne Lochner, Neelakandha S. Mani, Adrian Maurer, Daniel J. Pippel, Lana K. Young
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Patent number: 7981921Abstract: Disclosed are two new crystalline forms, ? and ?, of perindopril erbumine. Those forms are suitable as therapeutic active substances for medicaments for the treatment of cardiovascular diseases, especially high blood pressure and heart failure. The ? crystalline form is obtained in the crystallization of perindopril erbumine at from 30 to 45° C., preferably from 34 to 45° C., from MTBE containing from 1.5 to 2.5% (v/v) water; the crystallization is advantageously carried out with stirring. If the water is then removed, advantageously by azeotropic distillation, preferably at from 35 to 37° C., and stirring is then continued for at least 15 h at from 30 to 45° C., preferably from 35 to 37° C., the ? crystalline form is converted to the ? crystalline form. The ? crystalline form can also be obtained by stirring the ? or ? crystalline form at from 33 to 38° C. in tert.-butyl methyl ether containing from 0.9 to 1.4% (v/v) water with seeding with the ? crystalline form.Type: GrantFiled: March 9, 2010Date of Patent: July 19, 2011Assignee: Les Laboratoires ServierInventors: Christoph Strassler, Vit Lellek, Roger Fassler
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Publication number: 20100160404Abstract: Disclosed are two new crystalline forms, ? and ?, of perindopril erbumine. Those forms are suitable as therapeutic active substances for medicaments for the treatment of cardiovascular diseases, especially high blood pressure and heart failure. The ? crystalline form is obtained in the crystallisation of perindopril erbumine at from 30 to 45° C., preferably from 34 to 45° C., from MTBE containing from 1.5 to 2.5% (v/v) water; the crystallisation is advantageously carried out with stirring. If the water is then removed, advantageously by azeotropic distillation, preferably at from 35 to 37° C., and stirring is then continued for at least 15 h at from 30 to 45° C., preferably from 35 to 37° C., the ? crystalline form is converted to the ? crystalline form. The ? crystalline form can also be obtained by stirring the ? or ? crystalline form at from 33 to 38° C. in tert.-butyl methyl ether containing from 0.9 to 1.4% (v/v) water with seeding with the ? crystalline form.Type: ApplicationFiled: March 9, 2010Publication date: June 24, 2010Inventors: Christoph Strassler, Vit Lellek, Roger Fassler
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Patent number: 7705046Abstract: Disclosed are two new crystalline forms, ? and ?, of perindopril erbumine. Those forms are suitable as therapeutic active substances for medicaments for the treatment of cardio-vascular diseases, especially high blood pressure and heart failure. The ? crystalline form is obtained in the crystallization of perindopril erbumine at from 30 to 45° C., preferably from 34 to 45° C., from MTBE containing from 1.5 to 2.5% (v/v) water; the crystallization is advantageously carried out with stirring. If the water is then removed, advantageously by azeotropic distillation, preferably at from 35 to 37° C., and stirring is then continued for at least 15 h at from 30 to 45° C., preferably from 35 to 37° C., the ? crystalline form is converted to the ? crystalline form. The ? crystalline form can also be obtained by stirring the ? or ? crystalline form at from 33 to 38° C. in tert.-butyl methyl ether containing from 0.9 to 1.4% (v/v) water with seeding with the ? crystalline form.Type: GrantFiled: June 18, 2004Date of Patent: April 27, 2010Assignee: Les Laboratoires ServierInventors: Christoph Strassler, Vit Lellek, Roger Fassler
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Publication number: 20070299260Abstract: The invention concerns a method for preparing optionally substituted 3-indolcarboxylic acid esters, with hexahydro-8-hydroxy-2,6-methano-2H-chinolizin-3(4H)-one. The invention is characterized in that the optionally substituted 3-indolcarboxylic acid is converted by means of a suitable halogenating agent, into corresponding acid halide, preferably corresponding acid chloride, and the latter is transformed with hexahydro-8-hydroxy-2,6-methano-2H-chinolizin-3(4H)-one. The invention is characterized in that the entire reaction occurs in acid medium with a maximum pH of 7.Type: ApplicationFiled: November 25, 2004Publication date: December 27, 2007Applicant: CILAG LTD.Inventors: Hans-Ulrich Bichsel, Vit Lellek
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Publication number: 20070135512Abstract: Disclosed are two new crystalline forms, ? and ?, of perindopril erbumine. Those forms are suitable as therapeutic active substances for medicaments for the treatment of cardio-vascular diseases, especially high blood pressure and heart failure. The ? crystalline form is obtained in the crystallisation of perindopril erbumine at from 30 to 45° C., preferably from 34 to 45° C., from MTBE containing from 1.5 to 2.5% (v/v) water; the crystallisation is advantageously carried out with stirring. If the water is then removed, advantageously by azeotropic distillation, preferably at from 35 to 37° C., and stirring is then continued for at least 15 h at from 30 to 45° C., preferably from 35 to 37° C., the ? crystalline form is converted to the ? crystalline form. The ? crystalline form can also be obtained by stirring the ? or ? crystalline form at from 33 to 38° C. in tert.-butyl methyl ether containing from 0.9 to 1.4% (v/v) water with seeding with the ? crystalline form.Type: ApplicationFiled: June 18, 2004Publication date: June 14, 2007Inventors: Christoph Strassler, Vit Lellek, Roger Fassler