Abstract: Systems and methods for using distributed quantum-based computing simulators are disclosed. In one embodiment, a method may include: (1) receiving, at a driver node and from a service, a set of operations and a location for each operation compiled from a set of quantum computing instructions provided by a client device; (2) generating, by the driver node, a declarative instantiation plan for the set of operations identifying a plurality of worker nodes, each worker node corresponding to one of the locations; (3) instantiating, by the driver node, the declarative instantiation plan; (4) issuing, by the driver node, the operations to the worker nodes based on the locations for each operation; (5) receiving, by the driver node, results from each worker node; (6) aggregating, by the driver node, the results; and (7) returning, by the driver node, the aggregated results to the client device via the service.