Patents by Inventor Vitaly Arkadievich Livshits

Vitaly Arkadievich Livshits has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for producing purine nucleosides and nucleotides by fermentation using bacterium belonging to the genus or
    Patent number: 9012182
    Abstract: Methods for producing purine nucleosides, and purine nucleotides, such as inosine and 5?-inosinic acid are provided which include using a bacterium belonging to the genus Bacillus or to the genus Escherichia wherein the purine nucleoside productivity of said bacterium is enhanced by increasing an activity of the YdhL protein. Also disclosed is the amino acid sequence of the YdhL protein from Bacillus amyloliquefaciens and the gene encoding it.
    Type: Grant
    Filed: September 29, 2006
    Date of Patent: April 21, 2015
    Assignee: Ajinomoto Co., Inc.
    Inventors: Natalia Pavlovna Zakataeva, Vitaly Arkadievich Livshits, Sergey Viktorovich Gronsky, Ekaterina Aleksandrovna Kutukova, Anna Evgenievna Novikova, Yury Ivanovich Kozlov
  • Method for producing purine nucleosides and nucleotides by fermentation using a bacterium belonging to the genus or
    Patent number: 8034767
    Abstract: A method is provided for producing a purine nucleoside, such as inosine and guanosine, and a method for producing a 5?-purine nucleotide such as 5?-inosinic acid or 5?-guanylic acid, using a bacterium belonging to the either genus Escherichia or genus Bacillus, wherein purine nucleoside productivity of said bacterium is enhanced by enhancing an activity of a protein encoded by the yeaS (leuE) gene.
    Type: Grant
    Filed: June 2, 2009
    Date of Patent: October 11, 2011
    Assignee: Ajinomoto Co., Inc.
    Inventors: Ekaterina Aleksandrovna Kutukova, Natalia Pavlovna Zakataeva, Vitaly Arkadievich Livshits
  • METHOD FOR PRODUCING PURINE NUCLEOSIDES AND NUCLEOTIDES BY FERMENTATION USING A BACTERIUM BELONGING TO THE GENUS ESCHERICHIA OR BACILLUS
    Publication number: 20090298127
    Abstract: A method is provided for producing a purine nucleoside, such as inosine and guanosine, and a method for producing a 5?-purine nucleotide such as 5?-inosinic acid or 5?-guanylic acid, using a bacterium belonging to the either genus Escherichia or genus Bacillus, wherein purine nucleoside productivity of said bacterium is enhanced by enhancing an activity of a protein encoded by the yeaS (leuE) gene.
    Type: Application
    Filed: June 2, 2009
    Publication date: December 3, 2009
    Inventors: EKATERINA ALEKSANDROVNA KUTUKOVA, NATALIA PAVLOVNA ZAKATAEVA, VITALY ARKADIEVICH LIVSHITS
  • Method for Producing Purine Nucleosides and Nucleotides by Fermentation Using Bacterium Belonging to the Genus Bacillus or Escherichia
    Publication number: 20080241888
    Abstract: Methods for producing purine nucleosides, and purine nucleotides, such as inosine and 5?-inosinic acid are provided which include using a bacterium belonging to the genus Bacillus or to the genus Escherichia wherein the purine nucleoside productivity of said bacterium is enhanced by increasing an activity of the YdhL protein. Also disclosed is the amino acid sequence of the YdhL protein from Bacillus amyloliquefaciens and the gene encoding it.
    Type: Application
    Filed: September 29, 2006
    Publication date: October 2, 2008
    Inventors: Natalia Pavlovna Zakataeva, Vitaly Arkadievich Livshits, Sergey Viktorovich Gronsky, Ekaterina Aleksandrovna Kutukova, Anna Evgenievna Novikova, Yury Ivanovich Kozlov
  • Bacterial strain of BKIIM B-3996 as the producer of L-threonine
    Patent number: 7138266
    Abstract: A bacterial strain of Escherichia coli is described which produces L-threonine, and is obtained by a process comprising transduction by bacteriophage P1 which bears a transposon which inactivates threonine dehydrogenase activity, and isolation of a transductant lacking threonine dehydrogenase activity.
    Type: Grant
    Filed: September 2, 2003
    Date of Patent: November 21, 2006
    Assignee: Ajinomoto Co., Inc.
    Inventors: Vladimir Georgievich Debabov, Jury Ivanovich Kozlov, Evgeny Moiseevich Khurges, Vitaly Arkadievich Livshits, Nelli Isaakovna Zhdanova, Mikhail Markovich Gusyatiner, Alexandr Konstantinovich Sokolov, Tatyana Alexandrovna Bachina, Nikolai Kazimirovich Yankovsky, Jury Dmitrievich Tsygankov, Andrei Jurievich Chistoserdov, Tatyana Grigorievna Plotnikova, Irina Olegovna Shakalis, Alla Valentinovna Belareva, Raisa Alexandrovna Arsatiants, Albert Fedorovich Sholin, Tamara Mikhailovna Pozdnyakova
  • DNA coding for protein which confers on bacterium Escherichia coli resistance to L-homoserine, and method for producing L-amino acids
    Patent number: 6887691
    Abstract: A bacterium which has an ability to produce an amino acid and in which a novel gene (rhtB) coding for a protein having an activity of making a bacterium having the protein L-homoserine-resistant is enhanced, is cultivated in a culture medium to produce and accumulate the amino acid in the medium, and the amino acid is recovered from the medium.
    Type: Grant
    Filed: May 3, 2001
    Date of Patent: May 3, 2005
    Assignee: Ajinomoto Co., Inc.
    Inventors: Vitaly Arkadievich Livshits, Natalya Pavlovna Zakataeva, Vladimir Venyamiovich Aleoshin, Alla Valentinovna Balareova, Irina Lvovna Tokhmakova
  • Bacterial strain of escherichia coli BKIIM B-3996 as the producer of L-threonine
    Publication number: 20040038380
    Abstract: A bacterial strain of Escherichia coli BKIIM B-3996, a producer of L-threonine, containing a recombinant plasmid pVIC40 and deposited on Nov. 19, 1987 in the collection of microorganism cultures at the USSR Antibiotics Research Institute under Reg. No. 1867.
    Type: Application
    Filed: September 2, 2003
    Publication date: February 26, 2004
    Applicant: Ajinomoto Co., Inc.
    Inventors: Vladimir Georgievich Debabov, Jury Ivanovich Kozlov, Evgeny Moiseevich Khurges, Vitaly Arkadievich Livshits, Nelli Isaakovna Zhdanova, Mikhail Markovich Gusyatiner, Alexandr Konstantinovich Sokolov, Tatyana Alexandrovna Bachina, Nikolai Kazimirovich Yankovsky, Jury Dmitrievich Tsygankov, Andrei Jurievich Chistoserdov, Tatyana Grigorievna Plotnikova, Irina Olegovna Shakalis, Alla Valentinovna Belareva, Raisa Alexandrovna Arsatiants, Albert Fedorovich Sholin, Tamara Mikhailovna Pozdnyakova
  • Bacterial strain of Escherichia coli BKIIM B-3996 as the producer of L-threonine
    Patent number: 6653111
    Abstract: The present invention provides a method for deriving an E. coli strain which produces L-theronine from E.coli strain VNIIgenetika 472T23 by transducing with bacteriophage P1 which bears a transposon.
    Type: Grant
    Filed: July 13, 2001
    Date of Patent: November 25, 2003
    Assignee: Ajinomoto Co., Inc.
    Inventors: Vladimir Georgievich Debabov, Jury Ivanovich Kozlov, Evgeny Moiseevich Khurges, Vitaly Arkadievich Livshits, Nelli Isaakovna Zhdanova, Mikhail Markovich Gusyatiner, Alexandr Konstantinovich Sokolov, Tatyana Alexandrovna Bachina, Nikolai Kazimirovich Yankovsky, Jury Dmitrievich Tsygankov, Andrei Jurievich Chistoserdov, Tatyana Grigorievna Plotnikova, Irina Olegovna Shakalis, Alla Valentinovna Belareva, Raisa Alexandrovna Arsatiants, Albert Fedorovich Sholin, Tamara Mikhailovna Pozdnyakova
  • DNA coding for protein which confers on bacterium Escherichia coli resistance to L-homoserine, and method for producing L-amino acids
    Publication number: 20020102670
    Abstract: A bacterium which has an ability to produce an amino acid and in which a novel gene (rhtB) coding for a protein having an activity of making a bacterium having the protein L-homoserine-resistant is enhanced, is cultivated in a culture medium to produce and accumulate the amino acid in the medium, and the amino acid is recovered from the medium.
    Type: Application
    Filed: May 3, 2001
    Publication date: August 1, 2002
    Applicant: AJINOMOTO CO., INC.
    Inventors: Vitaly Arkadievich Livshits, Natalya Pavlovna Zakataeva, Vladimir Venyamiovich Aleoshin, Alla Valentinovna Balareova, Irina Lvovna Tokhmakova
  • DNA coding for protein which confers on bacterium escherichia coli resistance to L-homoserine, and method for producing L-amino acids
    Publication number: 20020058314
    Abstract: A bacterium which has an ability to produce an amino acid and in which a novel gene (rhtB) coding for a protein having an activity of making a bacterium having the protein L-homoserine-resistant is enhanced, is cultivated in a culture medium to produce and accumulate the amino acid in the medium, and the amino acid is recovered from the medium.
    Type: Application
    Filed: August 13, 2001
    Publication date: May 16, 2002
    Applicant: AJINOMOTO CO., INC.
    Inventors: Vitaly Arkadievich Livshits, Natalya Pavlovna Zakataeva, Vladimir Venyamiovich Aleoshin, Alla Valentinovna Balareova, Irina Lvovna Tokhmakova
  • Bacterial strain of escherichia coli BKIIM B-3996 as the producer of L-threonine
    Publication number: 20010049129
    Abstract: A bacterial strain of Escherichia coli BKIIM B-3996, a producer of L-threonine, containing a recombinant plasmid pVIC40 and deposited on Nov. 19, 1987 in the collection of microorganism cultures at the USSR Antibiotics Research Institute under Reg. No. 1867.
    Type: Application
    Filed: July 13, 2001
    Publication date: December 6, 2001
    Applicant: Ajinomoto Co., Inc.
    Inventors: Vladimir Georgievich Debabov, Jury Ivanovich Kozlov, Evgeny Moiseevich Khurges, Vitaly Arkadievich Livshits, Nelli Isaakovna Zhdanova, Mikhail Markovich Gusyatiner, Alexandr Konstantinovich Sokolov, Tatyana Alexandrovna Bachina, Nikolai Kazimirovich Yankovsky, Jury Dmitrievich Tsygankov, Andrei Jurievich Chistoserdov, Tatyana Grigorievna Plotnikova, Irina Olegovna Shakalis, Alla Valentinovna Belareva, Raisa Alexandrovna Arsatiants, Albert Fedorovich Sholin, Tamara Mikhailovna Pozdnyakova
  • DNA coding for protein which confers on bacterium escherichia coli resistance to L-homoserine and method for producing L-amino acids
    Patent number: 6303348
    Abstract: A bacterium which has an ability to produce an amino acid and in which a novel gene (rhtB) coding for a protein having an activity of making a bacterium having the protein L-homoserine-resistant is enhanced, is cultivated in a culture medium to produce and accumulate the amino acid in the medium, and the amino acid is recovered from the medium.
    Type: Grant
    Filed: September 15, 1999
    Date of Patent: October 16, 2001
    Assignee: Ajinomoto Co., Inc.
    Inventors: VItaly Arkadievich Livshits, Natalya Pavlovna Zakataeva, Vladimir Venyamiovich Aleoshin, Alla Valentinovna Balareova, Irina Lvovna Tokhmakova
  • Escherichia coli strain and method for producing L-threonine
    Patent number: 6297031
    Abstract: E. coli strains derived form E. coli strain VNIIgenetika 472t23 and obtained by a process involving transduction by bacteriophage P1 which bears a transposon which inactivates threonine dehydrogenase activity and isolation of a transductant lacking threonine dehydrogenase activity are useful for producing L-threonine.
    Type: Grant
    Filed: June 22, 2000
    Date of Patent: October 2, 2001
    Assignee: Ajinomoto Co., Inc.
    Inventors: Vladimir Georgievich Debabov, Jury Ivancvich Kozlov, Evgeny Mciseevich Khurges, Vitaly Arkadievich Livshits, Nelli Isaakovna Zhdanova, Mikhail Markovich Gusyatiner, Alexandr Konstantinovich Sokolov, Tatyana Alexandrovna Bachina, Nikolai Kazimirovich Yankovsky, Jury Dmitrievich Tsygankov, Andrei Jurievich Christoserdov, Tatyana Grigorievna Plotnikova, Irina Clegovna Shakalis, Alla Valentinovna Belareva, Raisa Alexandrovna Arsatiants, Albert Fedorovich Sholin, Tamara Mikhailovna Pozdnyakova
  • Bacterial strain of Escherichia coli BKIIM B-3996 as the producer of L-threonine
    Patent number: 6165756
    Abstract: A bacterial strain of Escherichia coli BKIIM B-3996, a producer of L-threonine, containing a recombinant plasmid pVIC40 and deposited on Nov. 19, 1987 in the collection of microorganism cultures at the USSR Antiobiotics Research Institute under Reg. No. 1867.
    Type: Grant
    Filed: September 7, 1999
    Date of Patent: December 26, 2000
    Assignee: Ajinomoto Co., Inc.
    Inventors: Vladimir Georgievich Debabov, Jury Ivanovich Kozlov, Evgeny Moiseevich Khurges, Vitaly Arkadievich Livshits, Nelli Isaakovna Zhdanova, Mikhail Markovich Gusyatiner, Alexandr Konstantinovich Sokolov, Tatyana Alexandrovna Bachina, Nikolai Kazimirovich Yankovsky, Jury Dmitrievich Tsygankov, Andrei Jurievich Chistoserdov, Tatyana Grigorievna Plotnikova, Irina Clegovna Shakalis, Alla Valentinovna Belareva, Raisa Alexandrovna Arsatiants, Albert Fedorovich Sholin, Tamara Mikhailovna Pozdnyakova
  • Bacterial strain of Escherichia coli BKIIM B-3996 as the producer of L-threonine
    Patent number: 5976843
    Abstract: A bacterial strain of Escherichia coli BKIIM B-3996, a producer of L-threonine, containing a recombinant plasmid pVIC40 and deposited on Nov. 19, 1987 in the collection of microorganism cultures at the USSR Antibiotics Research Institute under Reg. No. 1867.
    Type: Grant
    Filed: July 9, 1997
    Date of Patent: November 2, 1999
    Assignee: Ajinomoto Co., Inc.
    Inventors: Vladimir Georgievich Debabov, Jury Ivanovich Kozlov, Evgeny Moiseevich Khurges, Vitaly Arkadievich Livshits, Nelli Isaakovna Zhdanova, Mikhail Markovich Gusyatiner, Alexandr Konstantinovich Sokolov, Tatyana Alexandrovna Bachina, Nikolai Kazimirovich Yankovsky, Jury Dmitrievich Tsygankov, Andrei Jurievich Chistoserdov, Tatyana Grigorievna Plotnikova, Irina Olegovna Shakalis, Alla Valentinovna Belareva, Raisa Alexandrovna Arsatiants, Albert Fedorovich Sholin, Tamara Mikhailovna Pozdnyakova
  • Bacterial strain of escherichia coli BKIIM B-3996 as the producer of L-threonine
    Patent number: 5705371
    Abstract: A bacterial strain of Escherichia coli BKIIM B-3996, a producer of L-threonine, containing a recombinant plasmid pVIC40 and deposited on Nov. 19, 1987 in the collection of microorganism cultures at the USSR Antibiotics Research Institute under Reg. No. 1867.
    Type: Grant
    Filed: April 16, 1996
    Date of Patent: January 6, 1998
    Assignee: Ajinomoto Co., Inc.
    Inventors: Vladimir Georgievich Debabov, Jury Ivancvich Kozlov, Evgeny Moiseevich Khurges, Vitaly Arkadievich Livshits, Nelli Isaakcvna Zhdanova, Mikhail Markovich Gusyatiner, Alexandr Konstantinovich Sokolov, Tatyana Alexandrovna Bachina, Nikolai Kazimirovich Yankovsky, Jury Dmitrievich Tsygankov, Andrei Jurievich Chistoserdov, Tatyana Grigorievna Plotnikova, Irina Clegovna Shakalis, Alla Valentinovna Belareva, Raisa Alexandrovna Arsatiants, Albert Fedorovich Sholin, Tamara Mikhailcvna Pozdnyakova
  • Strains of Escherichia coli which produce isoleucine or valine and a method for their production
    Patent number: 5658766
    Abstract: A method for constructing microorganism strains which produce amino acids comprising: combining in one bacterial genome (a) a mutation affecting the aminoacyl-tRNA synthetase corresponding to the selected amino acid, conferring cells auxotrophy which cannot be fully suppressed by addition of usual concentration this amino acid into the culture medium and (b) a mutation which destroys the negative regulation of selected amino acid biosynthesis to yield a strain capable of increased production of the selected amino acid.Strains producing isoleucine and valine.Methods to produce isoleucine and valine by culturing those strains.
    Type: Grant
    Filed: February 20, 1996
    Date of Patent: August 19, 1997
    Assignee: Ajinomoto Co., Inc.
    Inventors: Vitaly Arkadievich Livshits, Vladimir Georgievich Debabov, Aaveilova Oksaua Fedorovva, Zakataeva Natalya Pavlovva, Rustem Saidovich Shakulov, Tatyana Alexandrovna Bachina, Evgeny Moiseevich Khurges